Z Shanazari; M Faramarzi; E Banitalebi; R Hemmati
Abstract
Aim: One of the most important and prevalent disorders in elderly people is age-related muscular atrophy or Sarcopenia. Sarcopenia is associated with a significant reduction in muscle strength and volume. The purpose of this study was to investigate the effect of moderate and high intensity resistance ...
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Aim: One of the most important and prevalent disorders in elderly people is age-related muscular atrophy or Sarcopenia. Sarcopenia is associated with a significant reduction in muscle strength and volume. The purpose of this study was to investigate the effect of moderate and high intensity resistance training on serum levels of myostatin and IGF-1 in elderly rats Method: thirty male Wistar rats (23 months old) were randomly divided into two experimental and control group including moderate intensity resistance training (n = 10), high intensity resistance training (n = 10) and the control group (n = 10). Resistance training included 8 weeks of climbing a ladder with high intensity (80% MVCC) and moderate intensity (60% of MVCC) and 5 days a week. After completing training, serum concentration of IGF-1 and myostatin were measured using the ELISA method. Results: Myostatin concentration in decreased in high (916.5±43.1) and moderate (958.8±36.9) intensity resistance groups and IGF-1 increases in high (156.3±15.5) and moderate (141.8±7.4) intensity resistance groups (p<0.05). Also, there was significant difference between the IGF-I levels in high and moderate resistance training (p=0.009). However, there was no significant difference in myostatin level between groups. Conclusion: It seems that resistance training with moderate and high intensity can be change the resting levels of factors associated with muscular atrophy in elderly rats. However, there id further need to evaluate in human participants.
A Abbasi; M Faramarzi; M Ghatreh Samani; E Bbanitalebi
Abstract
Aim: NLRP-3 Inflammasome is considered an indicator of chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) which can result in secretion of IL-1β from adipose tissue. Despite numerous investigations on the underlying activation mechanisms of NLRP-3 in pathogenesis of T2DM, less ...
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Aim: NLRP-3 Inflammasome is considered an indicator of chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) which can result in secretion of IL-1β from adipose tissue. Despite numerous investigations on the underlying activation mechanisms of NLRP-3 in pathogenesis of T2DM, less attention has been paid to the impact of exercise on NLRP-3. Method: Male stereptpzosin-induces diabetic rats (n=40) were randomly assigned to five groups (n=8): diabetic+ low intensity endurance training (DL), diabetic+ moderate intensity endurance training (DM), diabetic+ high intensity endurance training (DH), non-diabetic with no training(CON), and diabetic with no training(D). Eight weeks of running (four sessions per week) with different intensities were completed. Western blotting method was used to measure NLRP3. ELISA technique was used to assess serum levels of insulin and glucose. Results: Results showed that expression of NLRP-3 protein were significantly lower in endurance DM (P<0.05) and endurance DH (P<0.05) groups against DL group. Caspase-1 expression was significantly lower in DL (P=0.001), DM (P<0.05), and DH (P<0.05) compared with D group. However, no significant different was found between the training groups. Serum insulin level was significantly lower in endurance DH group compared with endurance DL group (P<0.05).In comparison with D group, significant reduction of serum glucose was observed in endurance DL group (P<0.05), endurance DM (P<0.05), and endurance DH (P<0.05). Conclusion: It appears that training with high and moderate intensities induced positive modulation in NLRP-3 expression as well as improved glycemic factors levels.
Mohammad Faramarzi; Mohammadhosin Alizadeh; Ali Khazeni; Saeed Rostami
Volume 1, Issue 1 , April 2011, , Pages 23-50
Abstract
AbstractAim: The purpose of this study was to determine the effects of two ergogenic drinks on metabolic indices changes in soccer players.Method: Forty eight soccer players (24 women and 24 men) with mean age of 18.7 ± 4.7 years were selected as two groups, long-term and short-term intermittent exercise. ...
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AbstractAim: The purpose of this study was to determine the effects of two ergogenic drinks on metabolic indices changes in soccer players.Method: Forty eight soccer players (24 women and 24 men) with mean age of 18.7 ± 4.7 years were selected as two groups, long-term and short-term intermittent exercise. Then, each group randomly was divided into three; Zamzam (SD), Isostar (ID) and placebo (P) groups. Long-term intermittent exercise includes six stages of exercise in two half time. Fifteen minutes after breakfast, players have drunk 6 ml/kg of beverage and 1 ml/kg at the end of stages 1, 2, 4, and 5. In addition, they drank 4 ml/kg at the end of third stage (1st half time). Before and immediately after long-term intermittent exercise, blood glucose, insulin and triglyceride levels were measured. Blood lactate was measured at rest, 3 minutes after the first and second half time. Short-term intermittent exercise, includes three complete stages of RAST test with 10 minutes rest. Fifteen minutes after breakfast and at the end of each stage 2 ml/kg beverage were drunk. Glucose and blood lactate levels were measured at rest and immediately after each stage of RAST test. Results: Results showed that a significant increase in insulin and blood glucose levels after long-term activity in SD and ID groups. In addition, there was a significant increase in blood glucose levels at 3 minutes after every stage of the RAST test in SD and ID groups. However, in any variables, no significant difference was observed between ID and SD groups.Conclusion: It seems that the use of Zamzam and Isostar relatively the same rate increase level of blood glucose and insulin after long-term high- intensity intermittent exercise. Therefore, we can recommend to athletes to consume synergy beverage of Zamzam which is produce in own country.Key words: Ergogenic beverage, Zamzam, Isostar, Ekblom test, Rast test
