Exercise Physiology
Mehdi Pahlevani; Jabbar Bashiri; Roghayeh Pouzesh Jadidi; Rasoul Hashem Kandi Asadi; Masoomeh Dadkhah
Abstract
Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental ...
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Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.
K Azali Alamadari; S Nasiri; Z Mohammadpour
Abstract
Aim: The aim of this study was to investigate the effects of aerobic training on serum Chemerin levels, inflammatory and cardio-metabolic risk factors in factors in midlife males complicated with metabolic syndrome.
Method: twenty six males with local Met criteria (age: 54.69±3.67 yrs., BMI: ...
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Aim: The aim of this study was to investigate the effects of aerobic training on serum Chemerin levels, inflammatory and cardio-metabolic risk factors in factors in midlife males complicated with metabolic syndrome.
Method: twenty six males with local Met criteria (age: 54.69±3.67 yrs., BMI: 31.21±1.23 kg/m2 and Vo2peak: 20.38±4.49 ml/kg.min) were randomly divided into aerobic training (n=14) and control (n=12) groups. Throughout eight weeks of training (3 sessions /week) the training load were increased from 15-20 min at 50-55% of HRpeak (end GXT heart rate) to 35-40 min at 60-65%. Blood samples were collected at baseline and 48 h after the intervention.
Results: Aerobic training induced significant reductions in all (except for HDL and Vo2peak) the investigated variables (P<0.05). At baseline, body weight and age were recognized as the most important predictors of serum Chemerin (P<0.05). Throughout the intervention period, the changes in blood glucose and CRP were the significant predictors of the concomitant changes in serum Chemerin levels (P<0.01), and the changes of Chemerin were the only predictor of the accompanying changes in CRP level (P<0.03). Conclusion: Chemerin reduces synchronously with the beneficial effects on metabolic and inflammatory indices as well as aerobic fitness level to be likely as the results from blood glucose and CRP modifications induced by aerobic training. However; more research remains to be done because of a little available evidence and limitations from this study.
Keywords: Aerobic training, Chemerin, CRP, Metabolic risk factor
