Metabolism and Exercise - Articles List

Introduction: Since drug treatments have limited effectiveness in Alzheimer's, attention has increased to non-pharmacological approaches, including physical activity and natural compounds ... Read More

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The effect of aerobic exercise and resveratrol on hippocampal mitochondrial fusion in rats with Alzheimer's disease

Saqqa Farajtabar Behrestaq; Mahla Hosseini Tabatabaei

Volume 15, Issue 2 , October 2025, , Pages 124-139

https://doi.org/10.22124/jme.2025.31445.422

Abstract

Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more than 50 million people worldwide. The aim of the present study was to determine the ... Read More

The effect of high intensity interval swimming on Nurr1 and mir-132 gene expression in rats with Parkinson's disease

Sahar Abdolahi; Mehrzad Moghadasi; Mohammdamin Edalatmanesh; Sara Hojati

Volume 14, Issue 1 , May 2024, , Pages 96-109

https://doi.org/10.22124/jme.2023.26124.333

Abstract

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. The effect of exercise on these neuron survivals ... Read More

The Effect of Eight-week Sprint Interval Training on Hippocampal Oxidative Stress Markers in Adult Male Wistar Rats

Fatemeh Beiksay Afshar; Esmaeil Nasiri; Ali Samadi

Volume 12, Issue 1 , March 2022, , Pages 59-72

https://doi.org/10.22124/jme.2023.23994.267

Abstract

Aim: The purpose of this study was to investigate the effect of sprint interval training on hippocampal oxidative stress markers hippocampus of adult male Wistar rats.Method: This is ... Read More

The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model

Fatemeh Akbari; mehrzad moghadasi; Sirus Farsi Farsi; Mohammad Amin Edalatmanesh

Volume 9, Issue 2 , November 2020, , Pages 137-147

https://doi.org/10.22124/jme.2020.15180.172

Abstract

The purpose of the present study was to examine the effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor (BDNF) and tyrosine kinase ... Read More

The effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in hippocampal tissue of male Wistar rats with Alzheimer's disease

A Fazeli Sani; hasan Matinhomaee; A Banaeifar

Volume 10, Issue 1 , May 2020

https://doi.org/10.22124/jme.2020.5775

Abstract

Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar ... Read More Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided into 3 groups: Alzheimer's disease (n = 7), Alzheimer's disease + aerobic exercise (n = 7) and control group (n = 7). Alzheimer's disease was induced by intrahippocampal injection of Aβ42 (1 microliter per side). Seven days after surgery, the exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes was assayed using Real Time-PCR. One-way analysis of variance was used for statistical analysis.Ethical Considerations: All stages of the study were conducted according to the ethical guidelines and authorization of Research Deputy of Islamic Azad University, Central Tehran Branch No. IR.IAU.TMU.REC.1399.124.Results: The results showed that spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001) as well as the gene expression of OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) in animals with Alzheimer's disease decreased compared to the control group, while the gene expression of Drp1 increased (P ≤ 0.001). Aerobic exercise in patient animals improved spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001), increased hippocampal OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) genes expression, and decreased Drp1 gene expression compared with Alzheimer's disease group (P ≤ 0.001).Conclusion: In general, it seems that aerobic exercise can improve spatial learning and memory performance in Alzheimer's disease by modulating abnormal mitochondrial dynamics.

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Volume 12 (2022)

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Volume 10 (2020)

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Volume 1 (2011)

Keywords = Hippocampus

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