Exercise Physiology
Mehdi Pahlevani; Jabbar Bashiri; Roghayeh Pouzesh Jadidi; Rasoul Hashem Kandi Asadi; Masoomeh Dadkhah
Abstract
Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental ...
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Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.
Arsalan Damirchi; Karim Azali Alamdari; Parvin Babaei
Volume 2, Issue 2 , July 2012, , Pages 135-147
Abstract
Abstract
Aim: Brain derived neurotrophic factor (BDNF) is an important factor affecting cognitive function which has recently interested a bulk trend of effort in the health context. In spite of a good body of evidence reported concern to positive association between aerobic fitness, cognitive function ...
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Abstract
Aim: Brain derived neurotrophic factor (BDNF) is an important factor affecting cognitive function which has recently interested a bulk trend of effort in the health context. In spite of a good body of evidence reported concern to positive association between aerobic fitness, cognitive function and serum BDNF, there is no enough information about the effect of aerobic training and also detraining period on memory function and circulatory BDNF in middle aged individuals.
Method: Twenty one middle aged males (age: 58.08±5.99, weight: 75.79±12.13 kg, BMI: 25.78±2.76 kg.m-2) randomized in two groups including aerobic exercise (Ex, n=11) and control (Con, N=10). Ex subjects participated in six weeks of endurance exercise sessions, 3 sessions/week by the intensity of 60-70% of HRR for 25 to 40 min in each min. Midterm and Short term memory tests were conducted and also blood samples were taken in three occasions including pretest, after six weeks of training and after the following six weeks of detraining period. Data were analyzed using independent t test, ANOVA and ANCOVA repeated measures.
Results: Six weeks of aerobic training in Ex group significantly increased basal serum BDNF level, and also short term and midterm memory function (P
