Exercise Physiology
faeghe ghasemi; Hamid Mohebbi
Abstract
Background and Purpose: Consuming a high-fat diet leads to disruption of liver mitochondrial biogenesis. Training exercise and hypoxia, which are new preventive or therapeutic strategies for obesity-induced NAFLD, may improve the impaired mitochondrial function. The aim of this study was to determine ...
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Background and Purpose: Consuming a high-fat diet leads to disruption of liver mitochondrial biogenesis. Training exercise and hypoxia, which are new preventive or therapeutic strategies for obesity-induced NAFLD, may improve the impaired mitochondrial function. The aim of this study was to determine the effect of nutrition, training and hypoxia on liver mitochondrial biogenesis in male Wistar rats. Methods: Thirty-two male rats (age: 6 weeks old; average weight: 167.25 grams) were randomly divided into four groups of eight including normal diet (ND), high-fat diet (HFD), high-fat diet and training in normoxia (HFD-HIIT) and high-fat diet and training in hypoxia (HFD-HHIIT). After determining the maximum aerobic velocity (MAV) in normoxia and hypoxia-hypobaric, the HIIT protocol was performed for 12 weeks and three sessions per week, which included 3 to 8 bouts 4-minute activity with an intensity of 80 to 93 percent of MAV and 2-minute active rest periods with an intensity of 50 percent of MAV. At the end, the levels of PGC-1α and Tfam genes were measured through RT-PCR. Results: Both HFD-HIIT and HFD-HHIIT groups showed a significant increase in the expression of PGC-1α and Tfam genes and a significant decrease in liver fat content compared to the HFD group (p<0.05). While, there was no significant difference in the expression of these genes between the two training groups. Conclusions: It seems that HIIT training has been able to increase mitochondrial biogenesis and reduce liver fat content independently of hypoxia conditions.
Z Khazraei Ganjifar; F Rahmani-nia
Abstract
Aim: The purpose of this study was to investigate the relationship between NT-proBNP, galactin-3 and aldosterone variables in endurance skiers after endurance skiing in height.
Method: Twenty four elite endurance skiers (age: 25 years; body fat: 14%) were divided into two groups (Experimental, Control). ...
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Aim: The purpose of this study was to investigate the relationship between NT-proBNP, galactin-3 and aldosterone variables in endurance skiers after endurance skiing in height.
Method: Twenty four elite endurance skiers (age: 25 years; body fat: 14%) were divided into two groups (Experimental, Control). The skiing program included a skiing route of 8.5 km, a mean time of 65 minutes, and an average intensity of 70-90% of the maximum oxygen consumption. The NT-proBNP values were evaluated by ELISA. A week after skiing, a ride on a treadmill was done with a slope and distance and a similar time with the ski resort. To examine the relationship between the variables studied, Pearson correlation coefficient was used at a significant level of 5% using SPSS version 22 software.
Results: : The results showed that only galatin-3 with NT-ProBNP and NT-ProBNP with aldosterone showed significant correlation in height (P<0.05).
Conclusion: Increasing physiological pressure on the heart caused by exposure to hypoxia and dehydration may lead to changes in the aldosterone and galactin-3 hormone as a fibrotic cell marker.
