Physical activity and wellness
Alireza Paahoo; Vahid Tadibi; Naser Behpoor
Abstract
Atherosclerosis is a chronic disease whose first stages can begin in childhood. Obesity is one of the major risk factors for atherosclerosis, which is becoming an epidemic. The increase in prevalence of obesity has focused more attention on the relationship between obesity and atherosclerosis, and although ...
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Atherosclerosis is a chronic disease whose first stages can begin in childhood. Obesity is one of the major risk factors for atherosclerosis, which is becoming an epidemic. The increase in prevalence of obesity has focused more attention on the relationship between obesity and atherosclerosis, and although the relationship between obesity and atherosclerosis has been widely reported, its potential mechanisms still need to be further elucidated. Salusins are a new class of bioactive peptides that play an important role as endogenous regulators of atherosclerosis process. Obesity is associated with a chronic inflammatory response characterized by abnormal adipokine production and activation of some pro-inflammatory signaling pathways. Past studies have shown that inflammatory process has a cause and effect relationship with obesity and cardiovascular diseases, including atherosclerosis. Also, arterial endothelial disorder is an early disorder in process of atherosclerosis, and presence of this disorder in obese children has been widely reported. The most important potential factor that will lead to obesity, inflammatory conditions and endothelial dysfunction is immobility. On the other hand, physical activity has wide health benefits and is considered as an important factor in primary and secondary prevention of cardiovascular diseases. Therefore, the current research seeks to investigate the role of physical activity in improving endogenous regulators of atherosclerosis in obese and sedentary children.
masume Kazemi; Sayad Mohmmad Marandi; Ahmand Movahedian Attar; Hosin Mohammadian; Hamid Reza Sharifi Jebeli
Volume 5, Issue 1 , June 2015, , Pages 1-9
Abstract
Aim: The aim of the present investigation is evaluate the effect of L- Arginine supplements on the oxidative and nitrosative stress in liver of rats following acute exercise on a treadmill. Method: Thirty two male Vistar rats (160-210 g) were randomly divided into four groups: control (C); L-Arg treatment ...
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Aim: The aim of the present investigation is evaluate the effect of L- Arginine supplements on the oxidative and nitrosative stress in liver of rats following acute exercise on a treadmill. Method: Thirty two male Vistar rats (160-210 g) were randomly divided into four groups: control (C); L-Arg treatment (Arg); exhaustive exercise (E); and exhaustive exercise with L-Arg treatment (E + Arg). E and E+Arg groups performed a 1 hour acute running test, or until exhaustion on a treadmill (16-26 m/min) and Arg and E+Arg groups treated orally with the L-Arg (2% diet, for 30 days). Sampling was performed 1 hour after exercise. Nitric oxide production was evaluated by measuring nitrite formation, using Griess reagent. oxidant-Antioxidant’s ratio was measured as TOS/ TAC levels. Results: According to the means of the oxidant-antioxidant’s balance (E)=0.91±0.12, (SC+Arg)=0.92 0.04 and (E+Arg)=0.91±0.09, TOS/TAC decreased in (E), (SC+Arg) and (E+Arg) groups compared with control group (SC); however, this decrease was not significant. And the results showed nitric oxide in (SC) group (mean=9.01 6.31 ) was more than other groups, but there was no significant change in there. Conclusion: The results of the present study didn’t show existence of oxidative-nitrosative stress and supplementation effect in muscle 1 h after acute exercise.
