Kazem Ranjbar; Hasan Matinhomaee; Mohammad Ali Azarbayjani; Maghsood Peeri
Volume 5, Issue 1 , June 2015, , Pages 35-44
Abstract
Aim: Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male rats toxicated by anabolic steroid. Method: 42 Wistar rats were randomly divided ...
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Aim: Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male rats toxicated by anabolic steroid. Method: 42 Wistar rats were randomly divided into six equal groups: group 1: control, group 2: sham, group 3: anabolic steroid (5 mg/kg), group 4: anabolic steroid (5 mg/kg) + zizyphus jujube extract (600 mg/kg), group 5: anabolic steroid (5 mg/kg) + resistance exercise, and group 6: anabolic steroid (5 mg/kg) + zizyphus jujube extract (600 mg/kg) + resistance exercise. Apart from the control and sham groups, anabolic steroid with a 5 mg per kg dose was injected to other groups once a week. The resistance exercise protocol were consisted of three exercise sessions per week by 5 repetitions in 3 sets of climbing ladder for eight weeks. The data were analyzed by the SPSS software, using ANOVA. Results: The results of this study revealed a significant increase in liver enzymes (ALT, AST, and ALP) and direct and total bilirubins in the anabolic steroid group (group 3) compared to the control and sham groups (p < 0.05). In addition, zizyphus jujube treatment (group 4), resistance exercise (group 5), and treatment with resistance exercise (group 6) caused a significant decrease in liver enzymes (ALT, AST, and ALP) and direct and total Bilirubins. There were no-significant differences in albumin concentration between experimental groups Conclusion: : Zizyphus jujube extract consumption as well as resistance exercise caused a significant decrease in liver damaging biomarkers. Hence, the simultaneous use of resistance exercise and zizyphus jujube extract did not show any increasing effect on these biomarkers.
