Document Type : Research Paper I Open Access I Released under (CC BY-NC) license


1 MSc in Exercise Physiology

2 Professor, University of Guilan


Aim: Irisin mediate the beneficial effects of exercise on energy metabolism. However, irisin response to resistance exercise and its related training variables has been less discussing. The purpose of this study was to determine the effect of resistance exercise order on serum irisin and blood lactate concentration in overweight women.
Method: Eight overweight women (age, 41.6±4.5 years; height, 161±0.1 cm; weight, 73.8±4.5 kg; BMI, 28.6±1 kg/m2) performed 2 exercise sessions separated by one week using a randomized cross-over design. The two sessions were composed of the same exercises performed in the opposite exercise order including: exercise order from large to small muscles (leg press, chest press, rows, leg extension, overhead press, leg curl, biceps curl, triceps extension) or small to large muscles (reverse sequence from large to small muscles). All exercises were performed with %80 1RM in 3 sets with 10 repetitions and 2 minutes of rest between the sets and exercises. Blood samples were collected before and immediately after exercise at each session. Data were analyzed using paired t-test and Pearson̕ s correlation coefficient.
Results: A significant increase was observed in the serum irisin and blood lactate immediately after both resistance exercise orders (P≤0.05). Blood lactate concentration after exercise order from large to small muscles significantly higher than exercise order from small to large muscles (P≤0.05), while, serum irisin changes were no significant between exercise orders. As well as, there was positive and significant correlation between lactate and irisin in both resistance exercise orders (P≤0.05).
Conclusion: Resistance exercise can lead to increase serum irisin in overweight women, that this enhancement is independent of exercise order.