Research Paper I Open Access I Released under (CC BY-NC) license
Nasrin Ramzany; Abasali Gaeini; Sirou Choobineh; Mohamadreza Kordi; Mehdi Hedayati
Volume 5, Issue 2 , February 2016, Pages 89-98
Abstract
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 ...
Read More
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 g) were selected as sample research. Diabetes was induced by using nikotinamid and streptozotocin. Five days after inducing diabetes, fasting blood was measured using blood glucose strips and rats that the level of fasting blood glucose was between 400-126 mg was selected as diabetic. Rats were randomly and According to homogenization of body weight assigned into two groups including control (n=9) and trained (n=9).Rats in the training groups carried out an 8-week exercise program on a motorized treadmill with 10–25 m/min for 15-40 min/day and a 5% slope for 5 days. Serum RBP4 levels was measured with Elisa method and insulin resistance was measured by HOMA-IR index. Results: Induction of diabetes caused a significant increase in body weight (p=0.001) and serum RBP4 (p<0.05). Also exercise caused a significant increase in muscle weight in the training group (p<0.05). Serum RBP4 levels after training significantly decreased in comparison with control groups (p<0.05). Also glucose, insulin and insulin resistance index were significantly decreased in the training group compared with the control group (p<0.05). Conclusion: it seems that 8 weeks aerobic training with 60-80% vo2max can be effective to decrease the serum RBP4 levels and insulin resistance index in type 2 diabetic patients.
Research Paper I Open Access I Released under (CC BY-NC) license
Parvin Khodadadi; Hamid Mohebbi
Volume 5, Issue 2 , February 2016, Pages 99-108
Abstract
Aim: Irisin mediate the beneficial effects of exercise on energy metabolism. However, irisin response to resistance exercise and its related training variables has been less discussing. The purpose of this study was to determine the effect of resistance exercise order on serum irisin and blood lactate ...
Read More
Aim: Irisin mediate the beneficial effects of exercise on energy metabolism. However, irisin response to resistance exercise and its related training variables has been less discussing. The purpose of this study was to determine the effect of resistance exercise order on serum irisin and blood lactate concentration in overweight women. Method: Eight overweight women (age, 41.6±4.5 years; height, 161±0.1 cm; weight, 73.8±4.5 kg; BMI, 28.6±1 kg/m2) performed 2 exercise sessions separated by one week using a randomized cross-over design. The two sessions were composed of the same exercises performed in the opposite exercise order including: exercise order from large to small muscles (leg press, chest press, rows, leg extension, overhead press, leg curl, biceps curl, triceps extension) or small to large muscles (reverse sequence from large to small muscles). All exercises were performed with %80 1RM in 3 sets with 10 repetitions and 2 minutes of rest between the sets and exercises. Blood samples were collected before and immediately after exercise at each session. Data were analyzed using paired t-test and Pearson̕ s correlation coefficient. Results: A significant increase was observed in the serum irisin and blood lactate immediately after both resistance exercise orders (P≤0.05). Blood lactate concentration after exercise order from large to small muscles significantly higher than exercise order from small to large muscles (P≤0.05), while, serum irisin changes were no significant between exercise orders. As well as, there was positive and significant correlation between lactate and irisin in both resistance exercise orders (P≤0.05). Conclusion: Resistance exercise can lead to increase serum irisin in overweight women, that this enhancement is independent of exercise order.
Research Paper I Open Access I Released under (CC BY-NC) license
Karim Azali Alamdari; Farhad Gholami
Volume 5, Issue 2 , February 2016, Pages 109-119
Abstract
Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors ...
Read More
Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors in patients with metabolic syndrome is unclear. Therefore, the aim of this study was to investigate the effect of eight weeks aerobic training on serum RBP-4 levels and insulin resistance in women with metabolic syndrome. Methods: In a semi-experimental study, 24 women with metabolic syndrome (age: 52.79±4.91 yrs, BMI: 32.77±2.37 Kg/m2 and VO2peak: 40±2.55 L/min) were randomly assigned into two groups including exercise (n=12) and control (n=12) groups. Aerobic exercise program was performed for 8 weeks, 3 sessions per week with an intensity of 50-60% of peak oxygen consumption for 20-40 minutes. Prior to the experimental period and 48h after last training session, body composition measurements were performed and blood samples were taken to be measured for serum levels of RBP-4, lipid profile, glucose and insulin. Insulin resistance index was also assessed. The data were analyzed using statistical tests of Paired and Independent t-test and Pearson's correlation test at significance level of PResults: The results showed that aerobic training significantly decreased serum RBP-4, glucose, insulin resistance index, body weight, body fat percentage, body mass index (BMI), waist circumference and metabolic syndrome Z score (P<0.05). Moreover, high density lipoprotein HDL - C levels significantly increased following eight weeks aerobic training (P<0.05). Pearson's correlation test revealed that changes in RBP-4 levels was significantly correlated with changes in body fat percentage, triglycerides, insulin and insulin resistance index (P<0.05). Conclusion: Overall, the results of this study indicated that aerobic training can reduce the RBP-4 levels and improve insulin resistance and some metabolic risk factors in women with metabolic syndrome. Insulin resistance improvement is likely to be resulted from decreased RBP-4 levels following aerobic training.
Research Paper I Open Access I Released under (CC BY-NC) license
N Khosravi; Hadi Rohani; S Ghaffari
Volume 5, Issue 2 , February 2016, Pages 121-132
Abstract
Aim: The aim of current study was to evaluate the effect of exercise day-time on maximal fat oxidation (MFO), exercise intensity (FATmax) and time (MFOtime) that elicite MFO and their relation to body composition in normal and overweight women. Metod: Forteen 20-30 years old students were randomly ...
Read More
Aim: The aim of current study was to evaluate the effect of exercise day-time on maximal fat oxidation (MFO), exercise intensity (FATmax) and time (MFOtime) that elicite MFO and their relation to body composition in normal and overweight women. Metod: Forteen 20-30 years old students were randomly selected and participated in to two normal waight (20<BMI-2) and overweight (BMI>25 kg.m-2) group. The data were analyzed using statical teats of dependent and paire T- test to copmair changes between session results. Resuils: Mean value of MFO at morning was significantly higher in overweight group than that in normal group (p<0.05). Also, no significant differences were observed between groups at evening. There was no significant relationship between body fat percent and MFO at morning, nor at evening; however, there was a significant negative relationship between body fat percent and MFOtime in overweight group at evening (r=-0.92, p<0.05). Conclusion: Generally, it seems that maximal fat oxidation during exercise is higher in the people who have more body fat percentage. However, this is eveident at morning rather than evening and enhancing fat oxidation at evening may need longer time exercise with higher intensity.
Research Paper I Open Access I Released under (CC BY-NC) license
Sharam Gholamrezaeii; Bahman Mirzaei; Hamid Arazi; Farhad Rahmani-nia
Volume 5, Issue 2 , February 2016, Pages 133-149
Abstract
Aim: The present study was carried out to determine the effect of garlic supplementation on some inflammatory indices following exhaustive aerobic exercise in sedentary female. Method: Nineteen volunteer sedentary young females (age 23.15±2.65 years, BMI 22.93±1.25 kg.m2,VO2max 30.36±4.5 ...
Read More
Aim: The present study was carried out to determine the effect of garlic supplementation on some inflammatory indices following exhaustive aerobic exercise in sedentary female. Method: Nineteen volunteer sedentary young females (age 23.15±2.65 years, BMI 22.93±1.25 kg.m2,VO2max 30.36±4.5 persent and bruce time 7.82±1.03) were assigned to a randomized and double-blind into two equal garlic (n=10) and placebo (n=9) groups. After 14 consecutive days supplementation (500 mg garlic or lactose every 12 hours a day), all subjects were participated in incremental aerobic exercise protocol (Bruce test). Changes in inflammatory and enzymatic markers were determined in four phases (before supplementation phase, before exercise, immediately and 24 hours after the aerobic exercise). Data were analyzed by repeated measure and independent T test at P≤0.05. Results: The results showed that one session of exhaustive aerobic exercise significantly increased some of the inflammatory and oxidative stress markers, in both groups (P≤0.05). Also, garlic supplement can decrease Hs-crp, Lymphocyte, Neutrophil, AST and ALT levels immediately after exercise protocol (P≤0.05). But other markers (total WBC, IL-6, LDH, CPK) were not changed significant. Conclusion: The results of this study showed that the garlic supplementation leads to decrease some of inflammatory and enzymatic indices of oxidative stress. Therefore, based on the present results, garlic supplementation can reduce the oxidative stress markers ranges following the exhaustive aerobic exercise.
Research Paper I Open Access I Released under (CC BY-NC) license
Majid Seifi Azarnejad
Volume 5, Issue 2 , February 2016, Pages 151-163
Abstract
Aim: silymarin has anti -inflammatory, antioxidant, stabilizes cell membranes and regulate cell permeability properties and could be prevent the undesirable some of muscle damage indices in patients and even athletes. The aim of this study was to investigate the potential cytoprotective effects of administration ...
Read More
Aim: silymarin has anti -inflammatory, antioxidant, stabilizes cell membranes and regulate cell permeability properties and could be prevent the undesirable some of muscle damage indices in patients and even athletes. The aim of this study was to investigate the potential cytoprotective effects of administration of silymarin in youth male soccer athletes after one-bout resistance exercise. Method: Eighteen young male soccer players (mean age 16.09±1.31 years, body fat 14.21±2.87% and BMI 21.96±0.70 kg.m2) in a quasi-experimental and randomized design. All subjects were divided in two homogeneous supplement and placebo groups of 9 subjects: (include: 140 mg capsules silymarin or dextrose 3 times daily for two week). After the supplementation, all subjects were participated a one- bout circle resistance exercise protocol (with 80 % 1-RM in 3 sets with 6 repetition) include six station participated. Changes in cellular damage indices (total serum CK and LDH) were determined in three stages (baseline, after supplementation period and 24 hours after the exercise). Data were analyzed by repeated measure ANOVA, bonferroni and independent t test at α≤0.05. Results: The results showed that the silymarin supplementation had no significant effect on the basal cell enzymes activity (P≥0.05). Moreover, resistance exercise significantly increased level of cellular injury serum enzymes 24-hour after exercise in both group (P≤0.05). However, the change range in all of cell enzymes activity of placebo group was significantly more than in the silymarin group after 24 hours of exercise (P≤0.05). Conclusion: Based on the present findings, it maybe concluded that silymarin supplementation did significantly prevent further undesirable changes resistance exercise-induced cell damage in young male soccer players.
