Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 3. Assistant Professor, Department of Physical Education and Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 Azad universitaly
3 Azad university bojnord
Abstract
One of the common disorders in old age is sarcopenia, which leads to a five percent decrease in muscle mass every year. The aim of this study was to investigate the effect of resistance and endurance training on the expression of MURF1 and MTOR genes in aged male rats. In this study, 30 elderly male rats were randomly divided into 3 groups: control, endurance training, and resistance training. The endurance and resistance group performed the exercises for 8 weeks and 5 sessions per week. 48 hours after the last training session and after overnight fasting, all aged male rats were killed and tissue was removed from the biceps muscle. Then, the expression level of MURF1 and mTOR genes was measured using the reference gene by Real Time PCR method. Data analysis was done by one-way variance tests and Tukey's test using SPSS software. The analysis of variance test showed that there is a significant difference in the expression of mTOR and MURF1 genes in different groups. (P>0.39) The results of Tukey's post hoc test showed that there is a significant difference between the control and resistance groups, and resistance training has a greater effect. It has endurance compared to training. The present study showed that resistance training has a greater effect on the activation of autophagy pathways in skeletal muscle than endurance training. Therefore, it seems that resistance training is a more effective training method in improving the expression of genes involved in the promotion of sarcopenia with aging.
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