Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of Physical Education and Sports Science, Payame Noor University, PO Box 3697-19395 Tehran, Iran
2 Payame Noor University
3 payame noor University yazd-iran
Abstract
Objectives: Considering the protective and antioxidant properties of sports activities and quercetin supplementation on the levels of adiponectin and vascular endothelial growth factor in patients who suffer from diabetes and metabolic disorders for a long time, the aim of this study is the effect of aerobic exercise and quercetin supplementation on the levels of Adiponectin and vascular endothelial growth factor in heart tissue of diabetic rats.
Materials and methods: 50 male Wistar rats with an average weight of 237±33 grams were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes+supplement, diabetes+exercise and diabetes+supplement+exercise. The protocol included eight weeks of High intensity aerobic exercise, five sessions per week and 60 minutes per session, and the supplement groups also received quercetin in the amount of 50 mg per kg of body weight by daily gavage. Changes in the levels of adiponectin and vascular endothelial growth factor were investigated using the ELISA. One-way analysis of variance and Tukey's test were used to analyze the data.
Findings: The results showed that there is a significant difference between groups in the values of adiponectin and vascular endothelial growth factor (P=0.001). The changes of adiponectin and vascular endothelial growth factor between exercise+supplement, exercise and supplement with diabetes groups were also significantly different (P=0.001).
Conclusion: It seems that the use of quercetin supplement and intense continuous training has led to an increase in the levels of adiponectin and VEGF in diabetic rats, and it indicates their importance in reducing risk factors in diabetes.
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