Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2 Associate Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
3 department of sport physiology,ayatollah amoli branch,,islamic azad university
Abstract
Background: Promoting regular exercise and a diet containing polyphenols are effective non-pharmacological approaches that prevent the progression of neurodegenerative diseases. In this study, we measured markers of inflammation and antioxidant after 8 weeks of exercise training (T), resveratrol (RSV) treatment, or combination treatment in rat model of AD.
Materials & Methods: In this experimental study, 35 male Wistar rats were divided into 5 groups: Normal (NO), Alzheimer's (AD), Alzheimer's-Training (ADT), Alzheimer's-Resveratrol (ADRSV) and Alzheimer's-Training-Resveratrol (ADTRSV). The supplement groups received 20 mg of RSV (per kg of body weight) orally during the intervention period. Aerobic exercise program including running on treadmill with a speed of 6-18 meters per minute, was performed 5 days a week for eight weeks.
Results: AD induction caused a significant decrease in antioxidant indices (Gpx, SOD and CAT) and increased MDA, NF-κB, TNF-α and IL-1β (p=0.0001). Exercise and RSV decreased and increased the antioxidant indices and the expression of inflammatory factors (p<0.05). It was also observed a significant increase in Gpx and SOD levels in the ADTRSV compared to the ADT (p=0.043, p=0.041) and ADRSV (p=0.026, p=0.035, respectively). The expression of NF-κB and TNF-α was significantly decreased in ADTRSV compared to ADT (p=0.040 and p=0.041) and ADRSV (p=0.044 and p=0.034).
Conclusion: T and RSV play a role in the improvement and treatment of AD by affecting inflammation and oxidative stress. Nevertheless, the effect of the combination of exercise and supplementation was greater.
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