Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Assistant Professor of Farhangian Alborz University
2 1- M.A , department of physical education and sport sciences, Markazi branch, Islamic azad university, Tehran, Iran
Abstract
Aim: Menopause is a natural physiological process of the body, but the changes caused by the decrease of estrogen during this period may cause damage to the hippocampus of some women and affect their quality of life. The aim of the present study was to investigate the effect of increasing resistance training and vitamin C nanoliposome supplementation on the expression of genes involved in autophagy of hippocampal tissue of orectomized rats.
Methods32 ovariectomized 24-month-old rats were divided into 4 groups: control, supplement (vitamin C nanoliposome), combined (resistance training + supplementation and training). Resistance training included eight weeks of moderate intensity ladder training (70% of MVCC) and five days a week. In the supplement groups, 5 days a week and for 8 weeks, vitamin C supplement was received in the amount of 100 mg per kilogram of body weight. PRDX6 and GCN5L1 Hippocampal tissue was obtained using Real-time PCR method and statistical analysis was performed with two-way analysis of variance and Tukey's post hoc test.
Finding: The results showed a significant increase in PRDX6 and GNC5L1 gene expression in the hippocampus in the training and combined groups compared to the control and supplement groups (p=0.001). No significant difference was observed between the control and supplement groups (p=0.109).
Conclusion: Resistance training and vitamin C supplementation seem to play an important role in the processes leading to menopause by increasing the expression of the key regulator of mitophagy and inhibiting the phosphorylation of estrogen receptors.
Key words: resistance training, vitamin C, autophagyو orectomy.
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