Environmental stress in sports
mahdi faramoushi; Ramin Amirsasan; Vahid sari sarraf
Abstract
the aim of study was to investigate the effect of simulating staying at medium altitude along with consumption of thyme on the cardiomyopathy rate of type 2 diabetic rats and their simultaneous effect on liver enzymes.Methods: For this purpose, 40 Wistar rats were divided into five groups of eight. In ...
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the aim of study was to investigate the effect of simulating staying at medium altitude along with consumption of thyme on the cardiomyopathy rate of type 2 diabetic rats and their simultaneous effect on liver enzymes.Methods: For this purpose, 40 Wistar rats were divided into five groups of eight. In order to induce type 2 diabetes, streptozotocin was injected intraperitoneally.Altitude group was alternately placed for eight weeks in night sleep conditions at a simulated altitude in a hypoxia chamber, and thyme group was supplemented with thyme in the form of 400 mg/kg of hydroalcoholic extract in 30 ml of drinking water. Cardiomyopathy was measured through two indices of apoptosis (western blot) and fibrosis (staining), and diabetic indices, liver enzymes using methods Calorimetry was measured by biochemistry company.Results: The results showed that 8 weeks of altitude and thyme reduce the fasting glucose level in diabetics (P<0.05). Also, the results of the multivariate analysis of variance test showed Apoptosis and fibrosis showed a significant decrease in myocardial with exposure to altitude and simultaneous consumption of thyme (p<0.025). Also, moderate altitude and consumption of thyme extract had no significant effect on the serum levels of ALT and AST transaminases.Conclusion: Simulated moderate altitude and consumption of thyme in this research decreased fasting blood sugar and on the other hand, by reducing apoptosis and fibrosis, it prevented cardiomyopathy in the heart of type 2 diabetic rats, but these two variables did not cause a significant decrease in ALT and AST enzymes.
Kazem Ranjbar; Hasan Matinhomaee; Mohammad Ali Azarbayjani; Maghsood Peeri
Volume 5, Issue 1 , June 2015, , Pages 35-44
Abstract
Aim: Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male rats toxicated by anabolic steroid. Method: 42 Wistar rats were randomly divided into six equal groups: group 1: control, group 2: sham, group 3: anabolic steroid (5 mg/kg), group 4: anabolic steroid (5 ...
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Aim: Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male rats toxicated by anabolic steroid. Method: 42 Wistar rats were randomly divided into six equal groups: group 1: control, group 2: sham, group 3: anabolic steroid (5 mg/kg), group 4: anabolic steroid (5 mg/kg) + zizyphus jujube extract (600 mg/kg), group 5: anabolic steroid (5 mg/kg) + resistance exercise, and group 6: anabolic steroid (5 mg/kg) + zizyphus jujube extract (600 mg/kg) + resistance exercise. Apart from the control and sham groups, anabolic steroid with a 5 mg per kg dose was injected to other groups once a week. The resistance exercise protocol were consisted of three exercise sessions per week by 5 repetitions in 3 sets of climbing ladder for eight weeks. The data were analyzed by the SPSS software, using ANOVA. Results: The results of this study revealed a significant increase in liver enzymes (ALT, AST, and ALP) and direct and total bilirubins in the anabolic steroid group (group 3) compared to the control and sham groups (p < 0.05). In addition, zizyphus jujube treatment (group 4), resistance exercise (group 5), and treatment with resistance exercise (group 6) caused a significant decrease in liver enzymes (ALT, AST, and ALP) and direct and total Bilirubins. There were no-significant differences in albumin concentration between experimental groups Conclusion: : Zizyphus jujube extract consumption as well as resistance exercise caused a significant decrease in liver damaging biomarkers. Hence, the simultaneous use of resistance exercise and zizyphus jujube extract did not show any increasing effect on these biomarkers.
