Response and adaptation to exercises
sadegh cheragh birjandi; somaye rostamian dolat shanlo; Ali yaghobi
Abstract
One of the common disorders in old age is sarcopenia, which leads to a five percent decrease in muscle mass every year. The aim of this study was to investigate the effect of resistance and endurance training on the expression of MURF1 and MTOR genes in aged male rats. In this study, 30 elderly male ...
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One of the common disorders in old age is sarcopenia, which leads to a five percent decrease in muscle mass every year. The aim of this study was to investigate the effect of resistance and endurance training on the expression of MURF1 and MTOR genes in aged male rats. In this study, 30 elderly male rats were randomly divided into 3 groups: control, endurance training, and resistance training. The endurance and resistance group performed the exercises for 8 weeks and 5 sessions per week. 48 hours after the last training session and after overnight fasting, all aged male rats were killed and tissue was removed from the biceps muscle. Then, the expression level of MURF1 and mTOR genes was measured using the reference gene by Real Time PCR method. Data analysis was done by one-way variance tests and Tukey's test using SPSS software. The analysis of variance test showed that there is a significant difference in the expression of mTOR and MURF1 genes in different groups. (P>0.39) The results of Tukey's post hoc test showed that there is a significant difference between the control and resistance groups, and resistance training has a greater effect. It has endurance compared to training. The present study showed that resistance training has a greater effect on the activation of autophagy pathways in skeletal muscle than endurance training. Therefore, it seems that resistance training is a more effective training method in improving the expression of genes involved in the promotion of sarcopenia with aging.
Exercise Physiology
Sahar Ghasemi Pour; Sayyed Mohammad Marandi
Abstract
Oxidative stress is involved in occurrence and side effects of many diseases .Considering the high prevalence of diabetes in the society and the economic and health consequences caused by it, the present study tries to evaluate the effect of endurance exercise and chlorogenic acid on some pressure indicators.35 ...
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Oxidative stress is involved in occurrence and side effects of many diseases .Considering the high prevalence of diabetes in the society and the economic and health consequences caused by it, the present study tries to evaluate the effect of endurance exercise and chlorogenic acid on some pressure indicators.35 4 weeks male C57BL6 mice were randomly assigned to two groups of high-fat diet to induce pre-diabetes and normal diet. After induction of prediabetes,after 12 weeks of high fat diet consumption the samples of this group were divided into groups without intervention, chlorogenic acid consumption, endurance training, endurance training and chlorogenic acid (n=7). The training protocol was performed incrementally . Chlorogenic acid at the rate of 110 mg per kilogram of mouse weight was given to the groups . 24 hours after the last training session and consumption of chlorogenic acid, tissue removal was done from the quadriceps skeletal muscle and after weighing, it was taken to the laboratory to measure GPX, NO, TAC and MDA. One-way ANOVA test at 0.05 level was used to analyze the data. Findings: Endurance training decreased GPX, NO, TAC, and MDA. Chlorogenic acid decreased GPX, NO, and increased TAC and MDA, and their simultaneous intervention increased GPX, TAC, and MDA and decreased NO.According to the findings of this research, it seems that endurance exercise and chlorogenic acid consumption can be used as a non-pharmacological intervention to prevent oxidative stress in the body and its complications. It can also play a preventive role in diabetic patients.
Fatemeh Akbari; mehrzad moghadasi; Sirus Farsi Farsi; Mohammad Amin Edalatmanesh
Abstract
The purpose of the present study was to examine the effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor gene expression in the rats with hippocampal degeneration model. In this experiment, twenty four ...
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The purpose of the present study was to examine the effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor gene expression in the rats with hippocampal degeneration model. In this experiment, twenty four mature Sprague-dawley male rats were subjected to Alzheimer’s disease through intraperitoneally injection of 8 mg/kg Trimethytin (TMT) and then were divided into (1) Alzheimer-infected control group, (2) endurance training, and (3) sham to study the impact of the disease on the variables. Sixteen healthy rats were assigned to the control group that eight rats sacrifice at first week and eight rats sacrifice at last week. The rats in the endurance training group ran on a rat treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. To analyze the results of the tests, one-way ANOVA and Tukey post hoc test were run using SPSS The results revealed that induction of Alzheimer’s disease by TMT decreases the BDNF and TrkB receptor gene expression in rats. The results, also indicated that there were no significant differences in hypocampic BDNF and TrkB receptor gene expression between endurance training group and sham group. According to the study results, it seems that endurance training with specific intensity and duration utilized in this study had not significant effect on changes of hypocampic BDNF and TrkB receptor gene expression in the rats with hippocampal degeneration model.
M Gholami; E Eftekhari; A Zafari; O Solatzadeh
Abstract
Aim: despite role of aerobic exercise training in controlling type 2 diabetes, effectiveness of different aerobic training intensity’s and their mechanism is unknown. Therefore, the aim of present study was to investigate the effect of eight weeks' low and moderate intensity aerobic training on ...
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Aim: despite role of aerobic exercise training in controlling type 2 diabetes, effectiveness of different aerobic training intensity’s and their mechanism is unknown. Therefore, the aim of present study was to investigate the effect of eight weeks' low and moderate intensity aerobic training on levels of HbA1C, some hematological parameters and percent body fat in men with type 2 diabetes. Method: subjects in present study was consist of 33 obese and overweight men with type 2 diabetes with average age of 43.2 ± 8.03 and BMI 28.63 ± 2.71 that randomly assigned in three groups (11 in each group) including control, low intensity aerobic exercise training and moderate intensity aerobic training. Low intensity aerobic training program were performed with 50 percent of maximum heart rate (MHR) and moderate intensity aerobic training with 70 percent of MHR. Training program continued for eight weeks and three sessions in week for 45-60 minutes in each session. Results: results indicated that HbA1C, glucose and percent body fat significantly (p<0.05) decreased in both training groups. However, lipid profile significantly was improve only in moderate intensity aerobic training group. Moreover, HbA1C decrease and VO2peak increase in moderate intensity group was significantly diffrent to low intensity group. Conclusion: It seems that low intensity aerobic training in comparison to moderate intensity aerobic training are associated with lower adaptations and improvement in type 2 diabetes patient. Keywords: diabetes mellitus, hematologic parameters, endurance training, body fat percent, glycosylated hemoglobin (HbA1C)
Zinab Gurgin; Reza Gharakhanlou; Abdolhosin Parnow; Somayeh Rajabi; Mehdi Hedayati
Volume 1, Issue 1 , April 2011, , Pages 1-10
Abstract
Abstract Aim: Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic members of the ligand-gated ion-channel super-family. The Purpose of the present study was to investigate the effect of endurance, resistance and concurrent training on the content of nAChR in fast ...
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Abstract Aim: Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic members of the ligand-gated ion-channel super-family. The Purpose of the present study was to investigate the effect of endurance, resistance and concurrent training on the content of nAChR in fast skeletal muscles of male Wistar rats.
Method: Thirty male Wistar rats (220±15 gr) randomly were divided to four groups and followed 12 weeks of training according to the protocols. Animals of the endurance training group were exercised on treadmill for 12 weeks, 5 times a week, and 60 minutes a day at velocities up to 30 m/min. Animals of the Resistance group were housed in metal cage with a 2m high wire-mesh tower, with water bottles set at the top. Concurrent training group did both resistance and endurance trainings. Forty-eight hours after last session of protocols, animals were anaesthetized and the tibialis anterior (AT) was removed. For nAChR assay and for data analysis, ANOVA and independent- samples t- test were used.
Results: Data analysis showed that fast muscle nAChR content significantly difference between endurance, resistance and concurrent training groups with control group (P
