Exercise Physiology
Maryam Kafi; khadijeh irandoust
Abstract
Introduction: The aim of this study was to evaluate the importance of aerobic exercise and quercetin supplementation on the progression of colon cancer in rats and changes in the effects of IGF1 and myostatin on muscle tissue and the shape of fluctuations in atrophy and muscle wasting. Methods: The subjects ...
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Introduction: The aim of this study was to evaluate the importance of aerobic exercise and quercetin supplementation on the progression of colon cancer in rats and changes in the effects of IGF1 and myostatin on muscle tissue and the shape of fluctuations in atrophy and muscle wasting. Methods: The subjects of this study included 25 male Wistar rats (weight: 250± 30 g, age: 12 weeks) which were homogenized by weight and randomly divided into 5 groups (5 heads in each group) of healthy controls. Cancer control group, cancer group + quercetin supplement, cancer group + aerobic exercise, cancer group + quercetin supplement + aerobic exercise was evaluated. Measurements of IGF1 and myostatin in muscle tissue of rats were performed according to the standard and ELISA method. SPSS software was used for data analysis. Results: The results showed that 8 weeks of aerobic training in muscle tissue of mice with colon cancer had a significant effect on the mean values of myostatin (p = 0.005) and IGF1 (p = 0.019). 8 weeks of quercetin supplementation in muscle tissue of mice with colon cancer had a significant effect on mean myostatin and mean values IGF (P <0.05) in the control and experimental groups (8 weeks of quercetin supplementation) had no significant effect on mean myostatin and IGF1. (P>0/05) Conclusion: In general, the findings showed that aerobic exercise and quercetin supplementation improve IGF1 and reduce myostatin in muscle tissue of mice with colon cancer.
Exercise Physiology
Hannaneh khalili ateni; Rozita Fathi; khadijeh Nasiri; Abolfazl Akbari
Abstract
Aim: The aim of present study is to evaluate the effects of ten weeks of aerobic exercise and consumption of safflower seed extract on PIK3R1gene expression and serum creatinine levels in male rats, after consuming Dexamethasone.Method: 25 male Wistar rats (371± 32 gr) were randomly divided into ...
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Aim: The aim of present study is to evaluate the effects of ten weeks of aerobic exercise and consumption of safflower seed extract on PIK3R1gene expression and serum creatinine levels in male rats, after consuming Dexamethasone.Method: 25 male Wistar rats (371± 32 gr) were randomly divided into five groups including; control, dexamethasone, dexamethasone + safflower (500 mg/kg of body weight), dexamethasone + aerobic exercise (60 minutes, speed of 28m/min, 5 days a week), dexamethasone + safflower + aerobic exercise. Kidney damage was induced by subcutaneous injection of Dexamethasone (8 gr /kg of body weight) for 6 days. Results: Findings didn’t show a significant effect in the expression of PIK3R1 gene in different groups. Despite the observed changes in renal histology, dexamethasone caused insignificant changes in urea and uric acid. The results of this study showed that 10 weeks of consumption of safflower extract caused a significant decrease in urea and an insignificant increase in uric acid in mice with kidney damage. Also, 10 weeks of aerobic exercise significantly reduced urea, while causing an insignificant reduction in uric acid in mice with kidney damage. Despite changes in urea and uric acid, aerobic exercise and safflower extract can improve kidney damage.Conclusion: It seems that 10 weeks of aerobic exercise and consumption of safflower seed extract can be effective in improving kidney injury but the interveners in this study could not alter the expression of the PIK3R1 gene.
Exercise Physiology
Roghayeh Fakhrpour; Hamid Yazdanshenas
Abstract
Aim: choosing the type of sports activity for better effect in obese people can be considered as an important factor and challenge. On the other hand, Spexin plays a central and peripheral role in regulating satiety and food intake, motility of the digestive tract, energy metabolism and glucose/lipid ...
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Aim: choosing the type of sports activity for better effect in obese people can be considered as an important factor and challenge. On the other hand, Spexin plays a central and peripheral role in regulating satiety and food intake, motility of the digestive tract, energy metabolism and glucose/lipid metabolism. Therefore, the present study was conducted with the aim of comparing the effect of eight weeks of aerobic exercise and 30-20-10 on serum levels of spexin and lipid profile indices of obese men. Methods: The present experimental study and its statistical sample were 30 obese men who were randomly assigned to two groups of aerobic exercise and 30-20-10 exercise (15 people in each group). Aerobic exercise and 30-20-10 exercise were performed for eight consecutive weeks. Before and after the start of the protocol, height, weight, maximum oxygen consumption blood sampling from the brachial vein were performed to evaluate the amount of spexin and lipid profile.Results: The inter-group results showed that there was a significant difference in the levels of SPX and total cholesterol between the two groups of aerobic exercise and 30-20-10 exercise, so that by examining the difference in means, the greatest effect was after aerobic exercise. P = 0.001 and P = 0.005). But HDL levels were not significantly different between the two groups (P=215).Conclusion: According to the results of the present study, it is likely that aerobic exercise has a better effect on the serum levels of spexin and cholesterol in obese people than 10-20-30 exercises.
Fatemeh Kazeminasab
Abstract
Introduction: The aim of this study was to investigate the effect of aerobic exercise on the expression of lncRNAs associated with Glucose 6 phosphatase (G6P) and Glucokinase (GCK) in obese diabetic mice. Materials and methods: Eighteen C57BL/6 mice were divided into two groups: mice fed a high-fat diet ...
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Introduction: The aim of this study was to investigate the effect of aerobic exercise on the expression of lncRNAs associated with Glucose 6 phosphatase (G6P) and Glucokinase (GCK) in obese diabetic mice. Materials and methods: Eighteen C57BL/6 mice were divided into two groups: mice fed a high-fat diet (n=12) and mice fed a standard diet (n=6) for 16 weeks. Then, diabetic mice were divided into two groups: high-fat diet-exercise, high-fat diet-sedentary. The exercised mice were trained on a treadmill for 8 weeks at an average speed of 21 m/min for 50 minutes. Twenty-four hours after the last training session, the mice were sacrificed. Liver tissue was isolated and stored at -80°C. Results: The results showed that levels of hepatic glucose 6 phosphatase and MEG3 increased following a high-fat diet and decreased significantly in trained mice compared to untrained mice. In addition, the expression of glucokinase and lncLGR decreased in diabetic rats, but increased after exercise. Conclusion: The expression of Glucose 6 phosphatase may be regulated in liver tissue probably due to physical exercise and decreased MEG3 lncRNA expression. Exercise reduces the expression of MEG3, which regulates the expression of G6P in liver tissue. Under these conditions, gluconeogenesis and hepatic glucose production was reduced and insulin resistance was improved. Exercise also increased lncLGR expression, possibly leading to increased hepatic GCK expression. In this condition, blood glucose was reduced and stored in the form of glycogen in the liver.
A Fazeli Sani; hasan Matinhomaee; A Banaeifar
Abstract
Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided ...
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Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided into 3 groups: Alzheimer's disease (n = 7), Alzheimer's disease + aerobic exercise (n = 7) and control group (n = 7). Alzheimer's disease was induced by intrahippocampal injection of Aβ42 (1 microliter per side). Seven days after surgery, the exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes was assayed using Real Time-PCR. One-way analysis of variance was used for statistical analysis.Ethical Considerations: All stages of the study were conducted according to the ethical guidelines and authorization of Research Deputy of Islamic Azad University, Central Tehran Branch No. IR.IAU.TMU.REC.1399.124.Results: The results showed that spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001) as well as the gene expression of OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) in animals with Alzheimer's disease decreased compared to the control group, while the gene expression of Drp1 increased (P ≤ 0.001). Aerobic exercise in patient animals improved spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001), increased hippocampal OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) genes expression, and decreased Drp1 gene expression compared with Alzheimer's disease group (P ≤ 0.001).Conclusion: In general, it seems that aerobic exercise can improve spatial learning and memory performance in Alzheimer's disease by modulating abnormal mitochondrial dynamics.
E Akbarzadeh; H Mohebbi
Abstract
Aim: The body weight is controlled by the balance between energy intake and energy expenditure and also, the amount of exercise-induced weight loss, depends on the amount of the food intake. Milk has also been shown to be more satiating compared to carbohydrate drinks. Therefore the aim of this study ...
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Aim: The body weight is controlled by the balance between energy intake and energy expenditure and also, the amount of exercise-induced weight loss, depends on the amount of the food intake. Milk has also been shown to be more satiating compared to carbohydrate drinks. Therefore the aim of this study was to investigate the effect of milk consumption following exercise on appetite and energy intake in non-athlete females.
Method: Eight healthy non-athlete women (aged 23.25±2.19 years, BMI 21.71±2.42 Kg/m2) volunteered to participate in this study. The Subjects attended the laboratory on three separate randomized trials (there were 3 weeks between trials) during their follicular phase. After consuming a standardized breakfast at 08:00 a.m, 30 minutes continuous exercise was conducted on the cycle ergometer at 65% of the subject’s heart rate reserve. In one trial, the effect of exercise and in the other two trials, the effect of exercise and consuming 600ml of low-fat milk or orange juice (276 Kcal), were investigated on appetite and energy intake. The subject’s energy intake were calculated 60 minutes after exercise or drink ingestion. Also appetite sensations (hunger, fullness, satiety and desire to eat) were assessed using visual analogue scale.
Results: Absolute and relative energy intake were reduced significantly after consuming milk compared with two other trials (exercise,exercise+orange juice)(p<0.05). In addition, consuming milk after exercise in comparison with other trials, caused significant reduction in hunger and desire to eat and it also caused significant increase in fullness and satiety(p<0.05).
Conclusion: The results of this study showed that consuming milk could be useful for controlling the appetite after exercise. Moreover, it could be a part of the strategies for weight control programs.
Nader Shavandi; Abbas Saremi; Saeideh Tabibirad
Volume 3, Issue 1 , April 2013, , Pages 1-10
Abstract
Abstract
Aim: Endothelial dysfunction is considered an important event in atherosclerosis improvement. On the other hand, diabetes is also associated with endothelial dysfunction. Among the endothelial dysfunction factors, vascular cell adhesion molecule can be mentioned. The purpose of this study was ...
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Abstract
Aim: Endothelial dysfunction is considered an important event in atherosclerosis improvement. On the other hand, diabetes is also associated with endothelial dysfunction. Among the endothelial dysfunction factors, vascular cell adhesion molecule can be mentioned. The purpose of this study was the effect of aerobic exercise on VCAM-1 and insulin resistance index in type 2 diabetes women.
Method: Sixteen women suffering type 2 diabetes (aged: 50.81±7.87, weight: 75.82±15.27 kg) were randomly divided in aerobic (n=11) and control (n=5) groups. The aerobic group exercised for 8 weeks in 45-60 min sessions 3 time a week with 60% HRR. Blood samples were obtained after 10-12 overnight fasting for measuring VCAM-1 serum and insulin levels at pre-and post-exercise training. Statistical analysis was done by independent t-tests and Pearson correlation coefficient.
Results: The results showed a significant difference between aerobic and control groups in VCAM-1 serum levels (P
Afshar Jafari; Alireza Rostami; Vahid Sari-Sarraf
Volume 2, Issue 1 , April 2012
Abstract
Abstract
Aim: The aim of this study was to determin the effect of short-term Coenzyme Q10 supplementation on plasma lactate and serum total creatine kinase (CK) in healthy collegiate men after an aerobic exercise.
Method: Eighteen healthy untrained men (age 24±3 years, body fat 12±2%, and VO2max ...
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Abstract
Aim: The aim of this study was to determin the effect of short-term Coenzyme Q10 supplementation on plasma lactate and serum total creatine kinase (CK) in healthy collegiate men after an aerobic exercise.
Method: Eighteen healthy untrained men (age 24±3 years, body fat 12±2%, and VO2max 39±3 ml/kg/min) in a randomized and double-blind design were allocated in two equal groups: supplement group (n=9, Coenzyme Q10: 2.5 mg/kg/day) and placebo group (n=9, Dextrose: 2.5 mg/kg/day). After supplementation period, all subjects were participated in aerobic exercise protocol with 75% VO2max on the treadmill for 30 minutes. Blood samples obtained before the Q10 supplementation along with immediately before and after the exercise protocol, respectively. Plasma lactate and serum total creatine kinase were determined by automatic analyzers. Data were analyzed by repeated measure ANOVA, Bonferroni and independent t test at P≤0.05.
Results: The results show that short-term Coenzyme Q10 supplementation has no significant effect on basal parameters. However, plasma lactate and serum total CK were significantly increased (P
