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لیست داوران سال 1401

لیست داوران سال 1400

تاثیر همزمان مکمل گانودرما و تمرینات عملکردی ترکیبی بر سطوح سرمی SFRP5 و WNT5A در زنان میانسال مبتلا به دیابت نوع 2

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 استادیار گروه فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه مراغه، مراغه، ایران

2 دانشیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه مراغه، مراغه، ایران

10.22124/jme.2025.29486.386

چکیده

مقدمه: فاکتورهای التهابی به‌عنوان مکانیسم مهمی در بروز دیابت نوع دو و بیماری‌های متابولیک شناخته شده‌اند؛ درحالی‌که تمرینات ورزشی منظم اثرات ضدالتهابی داشته و موجب سرکوب التهاب سیستمیک با درجه پایین در دیابت نوع دو می‌شود. بنابراین، پژوهش حاضر با هدف بررسی تاثیر تمرینات فانکشنال ترکیبی همراه با مصرف مکمل گانودرما بر سطوح سرمی SPRF5، WNT5A و شاخص‌های گلایسمیک در زنان مبتلا به دیابت نوع دو انجام شد.
مواد و روش‌ها: تعداد 60 نفر از زنان مبتلا به دیابت نوع 2 بطور داوطلبانه در تحقیق حاضر شدند و به‌صورت تصادفی در چهار گروه: گروه تمرینات فانکشنال ترکیبی، گروه مکمل، گروه تمرین + مکمل، گروه کنترل قرار گرفتند. آزمودنی‌های گروه تمرینی به مدت 12 هفته و سه جلسه در هفته به تمرینات ورزشی منتخب پرداختند. مکمل گانودرما نیز روزانه سه ‌گرم به‌صورت دمنوش مصرف شد. مقادیر سرمی گلوکز خون ناشتا، شاخص مقاومت به انسولین، سطوح سرمی SFRP5 و WNT5A اندازه‌گیری شد.
نتایج: نتایج آزمون تحلیل واریانس نشان داد بین تاثیر مداخلات مختلف اختلاف معنی‌داری در سطوح سرمی SFRP5 و WNT5A، سطوح گلوکز خون و مقاومت انسولینی وجود دارد (05/0>p). تمرینات فانکشنال ترکیبی همراه با مصرف مکمل گانودرما منجر به کاهش سطوح سرمی WNT5A و افزایش سطوح سرمی SPRF5 در گروه‌های تمرین ، مکمل، تمرین+مکمل شد (001/0>p).
نتیجه‌گیری: هر دو روش مداخله تمرینات فانکشنال ترکیبی و مصرف مکمل گانودرما روش موثری در کنترل قند خون و کاهش التهاب باشند و ترکیب این دو روش اثربخشی بیشتری بر کنترل گلیسمی در بیماران مبتلا به دیابت نوع دو دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The simultaneous effect of Ganoderma supplementation and combined functional training on serum levels of SFRP5 and WNT5A in women with type 2 diabetes

نویسندگان [English]

  • samaneh dastah 1
  • Solmaz Babaei 2

1 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Maragheh University, Maragheh, Iran

2 Associate Professor, Faculty of Sport Sciences, University of Maragheh, Maragheh, Iran

چکیده [English]

Introduction: Inflammatory factors are known as an important mechanism in the development of type 2 diabetes and metabolic diseases; while regular exercise training has anti-inflammatory effects and suppresses low-grade systemic inflammation in type 2 diabetes. Therefore, the present study aimed to investigate the effect of combined functional training with Ganoderma supplementation on serum levels of SPRF5, WNT5A and glycemic indices in women with type 2 diabetes.
Materials and Methods: 60 women with type 2 diabetes voluntarily participated in the study and were randomly assigned to four groups: combined functional training group, supplement group, exercise + supplement group, and control group. Subjects in the exercise group performed selected exercise for 12 weeks, three sessions per week. supplement was also consumed daily in the form of tea, 3 grams. Serum fasting blood glucose levels, insulin resistance index, and serum SFRP5 and WNT5A levels were measured.
Results: The results of the analysis of variance test showed that there was a significant difference between the effects of different interventions on serum levels of SFRP5 and WNT5A, blood glucose levels and insulin resistance (p<0.05). Combined functional training combined with supplementation resulted in a decrease in serum levels of WNT5A and an increase in serum levels of SPRF5 in the exercise, supplement, and exercise + supplement groups (p<0.001).
Conclusion: Both intervention methods of combined functional training and supplementation are effective methods in controlling blood sugar and reducing inflammation, and the combination of these two methods is more effective in glycemic control in diabetic patients.

کلیدواژه‌ها [English]

  • Combined functional training
  • type 2 diabetes
  • Ganoderma supplementation
  • SPRF5
  • WNT5A
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سوخت و ساز و فعالیت ورزشی
دوره 15، شماره 1
مرداد 1404
صفحه 30-48
فایل ها
سابقه مقاله
  • تاریخ دریافت: 17 دی 1403
  • تاریخ بازنگری: 16 بهمن 1403
  • تاریخ پذیرش: 06 اسفند 1403
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