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لیست داوران سال 1401

لیست داوران سال 1400

تاثیر تمرین هوازی بر آنزیم‌های کبدی و مقاومت به انسولین در افراد مبتلا به دیابت نوع دو: مرور نظام‌مند و فراتحلیل

نوع مقاله : مقاله مروری Released under (CC BY-NC) license I Open Access I

نویسندگان

1 کارشناسی ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه سیستان و بلوچستان، زاهدان، ایران.

2 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه یاسوج، یاسوج، ایران.

3 استاد، گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران

10.22124/jme.2025.29671.390

چکیده

مقدمه: دیابت با تغییرات پاتولوژیکی زیادی در ارتباط است و آسیب‌های کبدی یکی از مهمترین پیامدهای دیابت است. هدف مطالعه حاضر، بررسی اثر تمرین هوازی بر آنزیم‌های کبدی و مقاومت به انسولین در افراد مبتلا به دیابت نوع دو (T2D) می‌باشد.
روش‌ کار: جستجوی سیستماتیک مقالات انگلیسی و فارسی منشر شده از پایگاه‌های اطلاعاتیPubMed ،Web of Science ، Scopus، ‌Magiran‌، Irandon،Noor Mags و Sid تا 25 دی‌ماه 1403 (14 ژانویه 2025) انجام شد. برای تعیین اندازه اثر، تفاوت میانگین WMD و فاصله اطمینان 95% با استفاده از مدل اثر تصادفی محاسبه شد. ناهمگونی با استفاده از آزمون I2 و سوگیری انتشار با تحلیل بصری فونل پلات و آزمون ایگر بررسی شد.
یافته‌ها: در مجموع 17 مطالعه (با 18 مداخله تمرین هوازی) و تعداد 564 آزمودنی مبتلا به T2D فراتحلیل شدند و نتایج نشان داد مداخله تمرین هوازی در افراد مبتلا به T2D با کاهش معنادار ALT ]002/0P= ،(781/11- الی 519/2-)Iu/l 150/7 -=‌[WMD، AST ]001/0P= ،(461/6- الی 550/1-)Iu/l 005/4 -=‌[WMD و ‌HOMA ]017/0P= ،(163/1- الی 113/0-) 638/0 -= [WMDنسبت به گروه شاهد شد. اما تمرین هوازی با تغییر غیرمعنادار GGT ]008/0P= ،(952/8- الی 362/1-)Iu/l 157/5 -= [WMD همراه شد.
نتیجه گیری: در مجموع، می‌توان تمرین هوازی را یکی از راهبردهای کارآمد در کاهش ATT، AST، GGT و HOMA در افراد مبتلا به دیابت T2D در نظر گرفت و پیشنهاد می‌‌شود از این روش برای بهبود ATT، AST، GGT و HOMA استفاده کنند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of aerobic exercise on liver enzymes and insulin resistance in people with type 2 diabetes: A systematic review and meta-analysis

نویسندگان [English]

  • Khadijeh Molaei 1
  • Omid Zafarmand 2
  • Mehdi Mogharnasi 3

1 MSc in Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran.

2 Department of Physical Education and Sport Science, School of Humanities, University of Yasouj, Yasouj, Iran.

3 Professor, Department of Sports Sciences, University of Birjand, Birjand, Iran.

چکیده [English]

Introduction: Diabetes is associated with many pathological changes, and liver damage is one of the most important consequences of diabetes. The aim of the present study was to investigate the effect of aerobic exercise on liver enzymes and insulin resistance in people with type 2 diabetes.
Methods: A systematic search of English and Persian published articles was conducted from PubMed, Web of Science, Scopus, Magiran, Irandon, Noor Mags, and Sid (14 January 2025). To determine the effect size, the mean difference WMD and 95% were calculated using a random effects model. Heterogeneity was assessed using the I2 test and publication bias was assessed using visual analysis of funnel plots and Egger's test.
Findings: A total of 17 studies (with 18 aerobic exercise interventions) and 564 subjects with T2D were meta-analyzed, and the results showed that aerobic exercise intervention in people with T2D was associated with a significant reduction in ALT [WMD= -7.150 Iu/l (-2.519 to -11.781), P=0.002], AST [WMD= -4.005 Iu/l (-1.550 to -6.461), P=0.001] and HOMA [WMD= -0.638, (-0.113 to -1.163), P=0.017] compared to the control group. However, aerobic exercise resulted in a non-significant change GGT [WMD= -5.157 Iu/l (-1.362 to -8.952), P=0.008] Came along.
Conclusions: In summary, aerobic exercise can be considered an efficient strategy in reducing ATT, AST, GGT, and HOMA in people with T2D, and it is recommended to use this method to improve ATT, AST, GGT, and HOMA.

کلیدواژه‌ها [English]

  • Aerobic exercise
  • liver enzymes
  • insulin resistance
  • type 2 diabetes
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سوخت و ساز و فعالیت ورزشی
دوره 15، شماره 1
مرداد 1404
صفحه 121-144
فایل ها
سابقه مقاله
  • تاریخ دریافت: 06 بهمن 1403
  • تاریخ بازنگری: 28 تیر 1404
  • تاریخ پذیرش: 01 مرداد 1404
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