نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 کارشناسی ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم اجتماعی، دانشگاه بین المللی امام خمینی، قزوین، ایران
2 دانشیار گروه علوم ورزشی، دانشکده علوم اجتماعی، دانشگاه بین المللی امام خمینی، قزوین، ایران
چکیده
هدف: تمرین مقاومتی محرکی برای القای هایپرتروفی عضلانی است و هایپرتروفی از طریق فرآیندهای مربوط به پروتئینهای ترشحشده از عضلات به نام مایوکاینها افزایش یابد. تمرین مقاومتی همراه با مداخله تغذیهای می توانند محرک غیر دارویی برای افزایش توده عضلات اسکلتی باشند. براین اساس، تحقیق حاضر باهدف تعیین تأثیر 6 هفته تمرین مقاومتی باتحمل وزن بدن همراه با مکمل امگا-3 بر برخی شاخصهای بزاقی هایپرتروفی عضلانی در زنان جوان، انجام شد.
مواد و روش ها: در این مطالعهی نیمه تجربی، 32 زن سالم (سن: 3.6 ± 23.38، وزن 8.27 ± 59.73(kg)، قد: 4.92 ± 165.20 (cm) و شاخص توده بدن: 2.57 ± 21.91 (kg/m²)) به صورت تصادفی به چهار گروه تمرین-مکمل (8 نفر)، تمرین (8 نفر)، مکمل (8 نفر) و کنترل(8 نفر) تقسیم شدند. برنامه تمرینات مقاومتی با تحمل وزن شامل سه جلسه تمرین در هفته با شدت 70-55 درصد یک تکرار بیشینه به مدت 6 هفته بود. پیش و پس از مداخله، شاخصهای1IGF- ، میوستاتین و آیریزین بزاق اندازهگیری شدند. دادهها با استفاده از تحلیل واریانس یک طرفه و آزمون t همبسته تجزیه و تحلیل شد.
یافته ها: نتایج نشان داد که تمرین مقاومتی باتحمل وزن بدن همراه با مکمل امگا-3، باعث کاهش معنیدار شاخص میوستاتین در گروه تمرین (05/0 > P) و همچنین عدم تغییر معنیدار شاخصهای IGF-1 و آیریزین در تمامی گروهها شد(05/0p>). با این وجود، در تمامی شاخصها بین گروهها هیچ تفاوت معنیداری مشاهده نشد(05/0p>).
نتیجهگیری: نتایج نشان داد که 6 هفته تمرین مقاومتی با تحمل وزن بدن همراه با مکمل امگا-3 باعث کاهش میوستاتین میشود.
کلیدواژهها
موضوعات
عنوان مقاله [English]
The effect of resistance training and omega-3 supplementation on some factors involved in muscle hypertrophy in young female
نویسندگان [English]
- Farnaz Alibabaeiyan Qazvini 1
- Abbas Sadeghi 2
- Hassan Pourrazi 2
1 Ms of exercise physiology, Department of Physical Education, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
2 Associate Professor, Department of Physical Education, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
چکیده [English]
Research Aim: Resistance exercise training (RET) is potential stimulus to induce hypertrophy and it can be increased through processes related to myokines which can be synthesized by skeletal muscle. Resistance exercise training with nutritional intervention has the potential to be a non-pharmacological stimulus to increase hypertrophy. Therefore, the purpose of this article was to contribute hypertrophy literature by assessing the effects of Weight-Bearing resistance training with omega-3 supplementation on some factors involved in muscle hypertrophy in young female.
Research method: Thirty-two healthy women (Age: 23.38 ± 3.6 years, weight 59.73 ± 8.27kg, height: 135.20 ± 4.92 cm and body mass index: 21.91 ± 2.57 kg/m²) were selected and randomly divided into four groups of control, consumed omega-3 supplementation (3g/d), and a combination of RET + omega-3 group. Then, subjects entered to 6 weeks of Weight Bearing resistance training. Saliva measurements were performed 48 hours before and after the start of the project in two stages of pre-test and post-test. Measurement of the levels of IGF-1,myostatin and Irisin was performed by ELISA method. The dependent t-test and one way ANOVA was used to analyse data by SPSS 26 software.
Findings: The results revealed that the level of myostatin in the training group was significantly different(P<0.05) and there was no statistically significant changes were observed for the level of both IGF-1 and Irisin (P> 0.05). It can be concluded that Weight-Bearing resistance training can reduce myostatin and prevent atrophy in young females.
کلیدواژهها [English]
- resistance training
- omega-3 supplementation
- IGF-1
- myostatin
- Irisin
1 Mitsui, T., et al., Pedometer-determined physical activity and indicators of health in Japanese adults. Journal of physiological anthropology, 2008. 27(4): p. 179-184.
- Nunes, J.A., et al., Salivary hormone and immune responses to three resistance exercise schemes in elite female athletes. The Journal of Strength & Conditioning Research, 2011. 25(8): p. 2322-2327.
- Zunner, B.E., et al., Myokines and resistance training: a narrative review. International Journal of Molecular Sciences, 2022. 23(7): p. 3501.
- O’Neill, B.T., et al., Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. The Journal of clinical investigation, 2016. 126(9): p. 3433-3446.
- Elkina, Y., et al., The role of myostatin in muscle wasting: an overview. Journal of cachexia, sarcopenia and muscle, 2011. 2: p. 143-151.
- Tierney, M.T., et al., STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nature medicine, 2014. 20(10): p. 1182-1186.
- Allen, D.L., D.S. Hittel, and A.C. McPherron, Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Medicine and science in sports and exercise, 2011. 43(10): p. 1828.
- Huh, J.Y., et al., Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. International journal of obesity, 2014. 38(12): p. 1538-1544.
- Chang, J.S., et al., Circulating irisin levels as a predictive biomarker for sarcopenia: A cross‐sectional community‐based study. Geriatrics & gerontology international, 2017. 17(11): p. 2266-2273.
- Tachtsis, B., D. Camera, and O. Lacham-Kaplan, Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration. Nutrients, 2018. 10(3): p. 309.
- Abdelhamid, A., et al., The relationship between omega-3, omega-6 and total polyunsaturated fat and musculoskeletal health and functional status in adults: a systematic review and meta-analysis of RCTs. Calcified tissue international, 2019. 105: p. 353-372.
- Bhullar, A.S., C.T. Putman, and V.C. Mazurak, Potential role of omega-3 fatty acids on the myogenic program of satellite cells. Nutrition and Metabolic Insights, 2016. 9: p. NMI. S27481.
- Mcglory, C., et al., Omega‐3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women. The FASEB Journal, 2019. 33(3): p. 4586-4597.
- Smith, G.I., et al., Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women. Clinical science, 2011. 121(6): p. 267-278.
- Peng, L.N., et al., Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass. Journal of cachexia, sarcopenia and muscle, 2018. 9(4): p. 635-642.
- Kruszewski, M. and M.O. Aksenov, Association of Myostatin Gene Polymorphisms with strength and muscle Mass in athletes: a systematic review and Meta-analysis of the MSTN Rs1805086 Mutation. Genes, 2022. 13(11): p. 2055.
- Campa, F., et al., Effects of a 12-week suspension versus traditional resistance training program on body composition, bioimpedance vector patterns, and handgrip strength in older men: a randomized controlled trial. Nutrients, 2021. 13(7): p. 2267.
- Langton, B. and J. King, Utilizing body weight training with your personal training clients. ACSM's Health & Fitness Journal, 2018. 22(6): p. 44-51.
- Heileson, J.L. and L.K. Funderburk, The effect of fish oil supplementation on the promotion and preservation of lean body mass, strength, and recovery from physiological stress in young, healthy adults: a systematic review. Nutrition Reviews, 2020. 78(12): p. 1001-1014.
- Thielecke, F. and A. Blannin, Omega-3 fatty acids for sport performance—are they equally beneficial for athletes and amateurs? a narrative review. Nutrients, 2020. 12(12): p. 3712.
- Fox, J., et al., Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: a meta‐analysis. Scandinavian journal of medicine & science in sports, 2018. 28(1): p. 16-28.
- Nygaard, H., et al., Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. PloS one, 2015. 10(3): p. e0121367.
- Winn, N.C., et al., Plasma irisin modestly increases during moderate and high-intensity afternoon exercise in obese females. PloS one, 2017. 12(1): p. e0170690.
- Cosio, P.L., et al., Effect of chronic resistance training on circulating irisin: systematic review and meta-analysis of randomized controlled trials. International journal of environmental research and public health, 2021. 18(5): p. 2476.
- Qiu, S., et al., Chronic exercise training and circulating irisin in adults: A meta-analysis. Sports medicine, 2015. 45: p. 1577-1588.
- Löffler, D., et al., Serum irisin levels are regulated by acute strenuous exercise. The Journal of Clinical Endocrinology & Metabolism, 2015. 100(4): p. 1289-1299.
- Briken, S., et al., Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of neuroimmunology, 2016. 299: p. 53-58.
- Kurdiova, T., et al., Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. The Journal of physiology, 2014. 592(5): p. 1091-1107.
- Abdulloh, I.N. and P.S. Rejeki, THE ROLE OF PHYSICAL EXERCISE INTESITY TO IRISIN LEVELS ON OVERWEIGHT AND OBESE. Folia Medica Indonesiana, 2021. 57(4): p. 357-364.
- Ahtiainen, J.P., et al., Effects of resistance training on expression of IGF-I splice variants in younger and older men. European journal of sport science, 2016. 16(8): p. 1055-1063.
- Izquierdo, M., et al., Differential effects of strength training leading to failure versus not to failure on hormonal responses, strength, and muscle power gains. Journal of applied physiology, 2006.
- Tomeleri, C.M., et al., Influence of resistance training exercise order on muscle strength, hypertrophy, and anabolic hormones in older women: a randomized controlled trial. The Journal of Strength & Conditioning Research, 2020. 34(11): p. 3103-3109.
- Gregory, S.M., et al., Exercise-induced insulin-like growth factor I system concentrations after training in women. Medicine and science in sports and exercise, 2013. 45(3): p. 420-428.
- Ansari Kolachahi, S., A. Elmieh, and M. Talebi, The effect of TRX exercises on serum levels of IGF-1 and cortisol and some health-related physical factors in active women. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch, 2020. 30(4): p. 432-442.
- Amirsasan, R., M. Armanfar, and J. Hesari, Serum levels of Insulin-like growth factor-1 (IGF-I) as an indicator associated with aerobic and anaerobic fitness assessment in adolescent boys. Medical Journal of Tabriz University of Medical Sciences, 2019. 41(4): p. 7-16.
- Kraemer, W.J. and N.A. Ratamess, Hormonal responses and adaptations to resistance exercise and training. Sports medicine, 2005. 35: p. 339-361.
- Jiang, Q., et al., The effect of resistance training on serum insulin-like growth factor 1 (IGF-1): a systematic review and meta-analysis. Complementary therapies in medicine, 2020. 50: p. 102360.
- Saibaba, G., et al., Ultrastructural and physico-chemical characterization of saliva during menstrual cycle in perspective of ovulation in human. Drug discoveries & therapeutics, 2017. 11(2): p. 91-97.
- Kazemi, F., The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men. Journal of Endocrinological Investigation, 2016. 39: p. 383-388.
- Raue, U., et al., Myogenic gene expression at rest and after a bout of resistance exercise in young (18–30 yr) and old (80–89 yr) women. Journal of Applied Physiology, 2006. 101(1): p. 53-59.
- Planella-Farrugia, C., et al., Circulating irisin and myostatin as markers of muscle strength and physical condition in elderly subjects. Frontiers in physiology, 2019. 10: p. 871.
- Santos, A., et al., Different resistance-training regimens evoked a similar increase in myostatin inhibitors expression. International journal of sports medicine, 2015. 36(09): p. 761-768.
- Willoughby, D.S., Effects of heavy resistance training on myostatin mRNA and protein expression. Medicine & Science in Sports & Exercise, 2004. 36(4): p. 574-582.
- Daďová, K., et al., Effect of calanus oil supplementation and 16 week exercise program on selected fitness parameters in older women. Nutrients, 2020. 12(2): p. 481.
- دیناروندی, et al., تأثیر دو هفته تمرین تناوبی سرعتی همراه با مصرف مکمل امگا-3 بر سطوح سرمی آیریزین، BDNF و نیمرخ لیپیدی دختران دارای اضافه وزن. مجله زنان، مامایی و نازایی ایران, 2020. 23(10): p. 72-81.
- Consitt, L.A. and B. Clark, The vicious cycle of myostatin signaling in sarcopenic obesity: myostatin role in skeletal muscle growth, insulin signaling and implications for clinical trials. The Journal of frailty & aging, 2018. 7(1): p. 21-27.
- Egerman, M.A. and D.J. Glass, Signaling pathways controlling skeletal muscle mass. Critical reviews in biochemistry and molecular biology, 2014. 49(1): p. 59-68.
- Śliwicka, E., et al., Serum irisin and myostatin levels after 2 weeks of high-altitude climbing. PLoS One, 2017. 12(7): p. e0181259.
- James, L., Omega-3 polyunsaturated fatty acid supplementation, sports performance and recovery. 2021, Loughborough University.