نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 دانشکدهی علوم ورزشی، دانشگاه مازندران، بابلسر، ایران
2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران
3 دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران
چکیده
مقدمه و هدف: هپاتوکینها تنظیمکنندههای کلیدی متابولیسم هستند. پروتئین شبه آنژیوپویتین 4 (ANGPTL4) نقش مهمی در تنظیم سوخت و ساز چربی دارد. هدف این مطالعه، بررسی و مقایسه اثرات تمرین مقاومتی فزاینده و بار ثابت بر سطوح کبدی و سرمیANGPTL4 در موشهای صحرایی تغذیه شده با محلول ساکارز بود.
روششناسی: سی و دو سر موش صحرایی نر نژاد ویستار (6 تا 8 هفتهای) بهطور تصادفی به چهار گروه: کنترل سالم، کنترل ساکارز، تمرین مقاومتی فزاینده + ساکارز و تمرین مقاومتی بار ثابت + ساکارز تقسیم شدند. پس از ۸ هفته تغذیه با محلول ساکارز ۱۰ درصد پروتکل تمرینی (۳ جلسه در هفته، به مدت ۸ هفته) شامل صعود از نردبان با وزنهی متصل به دم اجرا شد. سطوح ANGPTL4 در سرم و کبد و مقادیر سرمی کلسترول و تریگلیسیرید اندازهگیری شد.
نتایج: غلظت بافتی ANGPTL4 در گروه تمرین فزاینده نسبت به گروههای کنترل ساکارز (003/0P=) و تمرین بار ثابت (01/0P=) به طور معناداری بالاتر بود. اکتساب وزن بیشتر اما غیرمعنی دار (057/0P=) گروه کنترل شکر در مقایسه با گروه کنترل ساکارز مشاهده شد. سطوح تریگلیسیرید سرمی در گروههای مداخله تغذیه ای نسبت به گروه کنترل سالم بالاتر بود (001/0>P). مقادیر کلسترول سرمی در گروههای تمرین بار ثابت نسبت به کنترل ساکارز بهطور معناداری کمتر بود (048/0P=).
نتیجهگیری: افزایش معنی دار ANGPTL4کبدی بر اثر تمرین مقاومتی فزاینده، نشاندهنده اهمیت شدت تمرین بر تغییرات این هپاتوکین است. همچنین این پروتکل تمرینی می تواند در جلوگیری از افزایش وزن ناشی از مصرف زیاد ساکارز موثر باشد.
کلیدواژهها
موضوعات
عنوان مقاله [English]
The Effect of Progressive and Constant Load Resistance Training on Serum and Hepatic Levels of ANGPTL4 in Sucrose-Fed Rats
نویسندگان [English]
- Elham Khorrami 1
- Alireza Safarzade 2
- Elahe Talebi-Garakani 3
1 Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran
2 Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran
3 Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran
چکیده [English]
Background and Purpose: Hepatokines are key regulators of metabolism, and the angiopoietin-like protein 4 (ANGPTL4) plays an important role in lipid metabolism. This study aimed to compare the effects of progressive and constant-load resistance training on hepatic and serum ANGPTL4 levels in sucrose-fed rats.
Methods: Thirty-two male Wistar rats (6–8 weeks old) were randomly assigned to four groups: healthy control, sucrose control, progressive resistance training + sucrose, and constant-load resistance training + sucrose. After 8 weeks of feeding with 10% sucrose solution, training protocols (3 sessions per week, for 8 weeks) was implemented, including climbing a ladder with a weight attached to the tail. ANGPTL4 levels in serum and liver, and serum cholesterol and triglyceride levels were measured.
Results: Tissue concentrations of ANGPTL4 were significantly higher in the progressive resistance training group than in the sucrose control (P=0.003) and constant-load training (P=0.01) groups. More but non-significant weight gain (P=0.057) was observed in the sugar control group compared to the sucrose control group. Serum triglyceride levels were higher in the nutritional intervention groups than in the healthy control group (P<0.001). Serum cholesterol levels were significantly lower in the constant-load training groups compared to the sucrose control (P=0.048).
Conclusions: The significant increase in hepatic ANGPTL4 due to progressive resistance training indicates the importance of training intensity on changes in this hepatokine. This training protocol may also be effective in preventing weight gain caused by excessive sucrose consumption.
کلیدواژهها [English]
- Metabolic syndrome
- obesity
- resistance training
- ANGPTL4
- sucrose
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