نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 استادیار گروه علوم ورزشی دانشگاه شهید مدنی آذربایجان
2 کارشناس ارشد فیزیولوژی ورزش
چکیده
هدف: امروزه تاثیر ورزش بر بهبود کنترل دیابت محرز است و ترشح و عملکرد طبیعی انسولین نیازمند وجود منیزیم است و حتی منیزیم سبب بهبود حساسیت انسولینی می شود. ولی دیابت به کاهش منیزیم خون منجر میشود که آن هم در یک چرخه معیوب باعث وخیمتر شدن دیابت میشود. بااینحال در مورد تاثیر همزمان ورزش همراه با مصرف مکمل منیزیم بر کنترل دیابت اطلاعات زیادی فراهم نشده است. بنابراین هدف این تحقیق بررسی تاثیر توام هشت هفته تمرین هوازی و مصرف مکمل منیزیم بر کنترل متابولیک، مقدار انسولین، هموگلوبین گلیکوزیله و و منیزیم خون زنان دیابتی نوع دو بود.
روششناسی: روش تحقیق از نوع تجربی با طرح سه گروهی پیشآزمون پسآزمون بود. 30 زن داوطلب میان سال دیابتی نوعدو به طور تصادفی در سه گروه 10 نفری شامل تمرین-منیزیم، تمرین-دارونما و کنترل تقسیم شدند. گروه تمرین-منیزیم روزانه یک عدد قرص منیزیم 250 میلی گرم و گروههای تمرین-دارونما و کنترل روزانه یک عدد کپسول دارونما(حاوی نشاسته) را به مدت هشت هفته به صورت دوسوکور مصرف کردند. گروههایتمرین نیز هشت هفته تمرین هوازی شامل سه جلسه دویدن در هفته به مدت 60 دقیقه در هر جلسه با شدت 40 الی 60 درصد از ضربان قلب ذخیره انجام دادند. در دو وهله شامل پایه و پس از مداخله خونگیری ناشتایی در ساعت 9-8 صبح انجام شد و دادهها با استفاده از تحلیل آزمون تی همبسته و تحلیل واریانس یکراهه با سطح اطمینان 05/0تحلیل شدند.
یافتهها: 30 درصد آزمودنیها در ابتدا دچار هیپومنیزیمی بودند. در طول مداخله مقدار منیزیم خون فقط در گروه تمرین-منیزیم افزایش یافت (05/0>P)؛ با اینحال در هر دو گروه تمرین، کاهش گلوکز خون، انسولین، هموگلوبین گلیکوزیله، تری گلیسرید، دور کمر و فشارخون مشاهده شد (05/0>P). همچنین مقدار کاهش گلوکز خون و انسولین در گروه تمرین-منیزیم ببشتر از گروه تمرین-دارونما بود (05/0>P).
نتیجهگیری: تمرین هوازی به همراه مصرف مکمل منیزیم در کنار سایر تمهیدات درمانی میتواند باعث کنترل بهتر دیابت شود.
کلیدواژهها
عنوان مقاله [English]
Synchronized effects of aerobic training and magnesium supplementation on cardiometabolic risk factors and A1c in Type 2 diabetic females
نویسندگان [English]
- K Azali Alamdari K 1
- M Bashiri 1
- R Shokrzadeh Agha Alilou 2
1 Assistant Professor of Azarbaijan Shahid Madani University
2 Msc in Exercise Physiology
چکیده [English]
Aim: Nowadays the effect of physical exercise on diabetes control improvement is evident and the both insulin release and function depends on magnesium (Mg) and Mg even improves insulin sensitivity. However; diabetes causes hypomagnesiumemia which in turn worsens glycemic control in a viscous cycle. Likewise; little is known about the synchronized effects of exercise training along with Mg supplementation on diabetes control. Therefore; the aim of this study was to investigate the synergistic effects from eight weeks of aerobic training and magnesium supplementation on metabolic control, blood insulin and glycosylated Hb (A1C) and Mg levels in female patients with type II diabetes.
Method: This study was done based on an experimental method using a pretest-posttest design. Thirty volunteer midlife type II diabetic females were randomized into training-Mg, training-placebo and control groups. The subjects consumed magnesium oxide or amylose containing pills (250 mg) once daily in a double blind order for eight weeks. The training groups also experienced eight weeks of moderate intensity aerobic training (3 sessions/week running for 60 min in each session at 40 to 60% of THR). Fasting blood samples were taken at two occasions between 8 to 9 am; baseline and after the intervention and the data were analyzed using paired samples t test and one way ANOVA at 95% significance level.
Results: 30% of the subjects had hypomagnesiumemia at baseline. Blood Mg was just elevated in the training-Mg group throughout the intervention (P<0.05). However; blood glucose, insulin, A1C, TG, waist circumference and blood pressure were all declined in both the training groups (P<0.05). Additionally, there were greater depressions in blood glucose and insulin levels of the training-Mg group rather than training placebo group (P<0.05).
Conclusion: Aerobic training and synchronized Mg supplementation could provide a better diabetes control along with other therapeutic proceedings.
کلیدواژهها [English]
- Keywords: Diabetes
- Aerobic training
- Magnesium
- A1C
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- Guerrero-Romero F, Simental-Mendía L, Hernández-Ronquillo G, Rodriguez-Morán M. Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial. Diabetes & metabolism. 2015;41(3):202-7.
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- Solati M, Ouspid E, Hosseini S, Soltani N, Keshavarz M, Dehghani M. Oral magnesium supplementation in type II diabetic patients. Medical journal of the Islamic Republic of Iran. 2014;28:67.
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- Bgeginski R, Ribeiro PA, Mottola MF, Ramos JGL. Effects of weekly supervised exercise or physical activity counseling on fasting blood glucose in women diagnosed with gestational diabetes mellitus: A systematic review and meta‐analysis of randomized trials. Journal of diabetes. 2017.
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- Rodriguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003; 26:52-58
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- Tosiello L. Hypomagnesemia and diabetes mellitus: a review of clinical implications. Archives of Internal Medicine. 1996;156(11):1143-8.
- Wegner M, Araszkiewicz A, Zozulinska-Ziolkiewicz D, Wierusz-Wysocka B, Piorunska-Mikolajczak A, Piorunska-Stolzmann M. The relationship between concentrations of magnesium and oxidized low density lipoprotein and the activity of platelet activating factor acetylhydrolase in the serum of patients with type 1 diabetes. Magnesium research. 2010;23(2):97-104. Epub 2010/05/29.
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- Mosayebi E, Sharifi M, Abedi A. Meta-analysis of Effectiveness of Psychological and SportInterventions on Control of meta-analysis of effectiveness of psychological and sport interventions on control of glycosylated haemoglobin in patients with diabetes in patients with diabetes. Iranian Journal of Diabetes and Lipid Disorders. 2016;15(4):201-16.
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- Klancic T, Woodward L, Hofmann SM, Fisher EA. High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties. Molecular metabolism. 2016;5(5):321-7.
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