نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی
2 دانشیار دانشگاه شهرکرد
3 استادیار دانشگاه شهرکرد
چکیده
هدف: یکی از اختلالات مهم و شایع در افراد سالمند، آتروفی عضلانی وابسته به سن یا سارکوپنیاست. سارکوپنیا با کاهش چشمگیر در قدرت و حجم توده عضلانی همراه است. هدف از این مطالعه بررسی تاثیر دو نوع تمرین مقاومتی شدید و متوسط بر سطوح سرمی مایوستاتین و IGF-1 سرم رتهای سالمند بود.
روش‌شناسی: سی سر رت نر نژاد ویستار مسن (23 هفته) به صورت تصادفی در دو گروه تمرینی و گروه کنترل شامل گروه تمرین مقاومتی با شدت متوسط (9=n)، تمرین مقاومتی با شدت بالا (8=n)، و گروه کنترل (8=n) قرار گرفتند. تمرین مقاومتی شامل 8 هفته تمرین مقاومتی نردبان با شدت زیاد ( 80% MVCC) و شدت متوسط (60% MVCC ) و 5 روز در هفته بود. بعد از دوره تمرین غلظت سرمی IGF-1و مایوستاتین به روش الایزا اندازهگیری شد.
یافته‌ها: غلظت مایوستاتین در گروه مقاومتی شدید (12/43±50/916) و مقاومتی متوسط (87/36±78/958) کاهش و غلظت IGF-1 در گروه مقاومتی شدید (49/15±27/156) و مقاومتی متوسط (42/7±77/141) افزایش معنیداری داشت (05/0P<). بین تاثیر تمرین مقاومتی شدید و متوسط بر سطوح IGF-1 تفاوت معنیدار (009/0p = ) بود. با این حال، در مورد مایوستاتین تفاوت معنیداری مشاهده نشد.
نتیجه‌گیری: به نظر میرسد تمرین مقاومتی با شدتهای متوسط و بالا میتواند باعث تغییر سطوح استراحتی عوامل مرتبط با آتروفی عضلانی در رتهای سالمند شود. با این حال، بررسی بیشتر در نمونههای انسانی ضروری به نظر میرسد.
کلیدواژه‌ها
عنوان مقاله [English]
The Eeffect of Eight Weeks Moderate and High Intensity Resistance Training on Resting Levels of Serum Myostatin and IGF-I in elderly Rats
نویسندگان [English]
- Z Shanazari 1
- M Faramarzi 2
- E Banitalebi 3
- R Hemmati 3
1 PhD student in exercise physiology
2 Associate Professor, Shahrekord University
3 Assistant professor, Shahrekord University
چکیده [English]
Aim: One of the most important and prevalent disorders in elderly people is age-related muscular atrophy or Sarcopenia. Sarcopenia is associated with a significant reduction in muscle strength and volume. The purpose of this study was to investigate the effect of moderate and high intensity resistance training on serum levels of myostatin and IGF-1 in elderly rats
Method: thirty male Wistar rats (23 months old) were randomly divided into two experimental and control group including moderate intensity resistance training (n = 10), high intensity resistance training (n = 10) and the control group (n = 10). Resistance training included 8 weeks of climbing a ladder with high intensity (80% MVCC) and moderate intensity (60% of MVCC) and 5 days a week. After completing training, serum concentration of IGF-1 and myostatin were measured using the ELISA method.
Results: Myostatin concentration in decreased in high (916.5±43.1) and moderate (958.8±36.9) intensity resistance groups and IGF-1 increases in high (156.3±15.5) and moderate (141.8±7.4) intensity resistance groups (p<0.05). Also, there was significant difference between the IGF-I levels in high and moderate resistance training (p=0.009). However, there was no significant difference in myostatin level between groups.
Conclusion: It seems that resistance training with moderate and high intensity can be change the resting levels of factors associated with muscular atrophy in elderly rats. However, there id further need to evaluate in human participants.
کلیدواژه‌ها [English]
- Myostatin
- IGF-1
- Rats Elderly
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