نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 دانشجوی فیزیولوژی ورزشی

2 دانشیار گروه فیزیولوژی ورزشی واحد آیت الله آملی، دانشگاه آزاد اسلامی

چکیده

هدف: در بیماران مبتلا به دیابت نوع 2 میزان اینکرتین‌ها کاهش می‌یابد. اینکرتین‌ها نقش مهمی در هموستاز گلوکز بازی می‌کنند. هدف از این پژوهش بررسی اثر تمرین هوازی همراه با مصرف خیار تلخ بر  اینکرتین سرمی در مردان دیابتی نوع 2 می‌باشد. 
روش‌شناسی: در این مطالعه، 36 مرد مبتلا به دیابت نوع 2 (سن 15/5 ± 08/53 سال، وزن 53/6 ± 08/78 کیلوگرم و شاخص توده بدنی 22/1 ± 22/26 کیلوگرم بر متر مربع) انتخاب و به­طور تصادفی به چهار گروه (کنترل-آب، کنترل-خیار تلخ، کنترل-تمرین و تمرین+خیار تلخ) تقسیم شدند. گروه­های تمرین به­مدت هشت هفته، هر هفته سه جلسه (دویدن با شدت 40 تا 70  درصد ضربان قلب ذخیره و مدت 15 تا 45 دقیقه) در برنامه تمرینی هوازی فزاینده شرکت کردند. گروه­های کنترل-خیار تلخ و تمرین+ خیار تلخ ، 2000 میلی­گرم پودر خشک میوه خیار تلخ (در کپسول‌های 500 میلی‌گرم) را به مدت هشت هفته (دوبار در روز قبل از صبحانه و شام) مصرف نمودند. دو روز قبل و بعد از اجرای پروتکل، در حالت ناشتا نمونه گیری از خون  انجام شد.
یافته‌ها: نتایج نشان داد که میزان GLP-1 و GIP در همه گروه‌های تجربی نسبت به گروه کنترل افزایش معنی‌داری داشت (05/0 p≤)، همچنین میزان GLP-1 گروه تمرین-خیار تلخ نسبت به گروه خیار تلخ و GIP گروه تمرین-خیار تلخ نسبت به گروه خیار تلخ و تمرین افزایش معنی‌داری داشت (05/0 p≤). از دیگر نتایج، افزایش معنی‌دار در میزان  GLP-1و GIP همه گروه‌های تجربی نسبت به پیش آزمون بود (05/0 p≤).
نتیجه‌گیری: در مجموع می­توان گفت تمرین و خیار تلخ و ترکیب این دو، باعث بهبود عوامل موثر بر کنترل گلیسیمیک در مردان مبتلا به دیابت نوع 2 می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of aerobic training along with Momordica charantia L on serum incretin levels in type 2 diabetes men

نویسندگان [English]

  • O Mohajer Iravani 1
  • A Abdi 2
  • A Abbassi Daloii 2

1 PhD Student in Exercise Physiology

2 Associate Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University

چکیده [English]

Aim: : In type 2 diabetes patients, the level of incretins is reduced. Incretins play an important role in glucose homeostasis. The aim of this study was to examine the effect of aerobic training along with Momordica charantia L on serum incretin levels in man with type 2 diabetes.
Method: In this study, 36 men with type 2 diabetes (age 53.08±5.15 years, wight 78.08±6.53kg and BMI 26.22±1.2218 kg/square meters) were selected and were randomly divided into four groups (Control-Water, Control-Momordica charantia, Control-Training and Momordica charantia+Training). The training groups participated in a progressive aerobic training for eight weeks, three sessions a week (running with 40% to 70% of the reserved heart rate and for 15 to 45 min). The groups of Control-Momordica charantia and Momordica charantia+Training were provided 2000 mg of Momordica charantia (In 500 mg capsules) for eight weeks (Twice a day before breakfast and dinner). Two days before and after the protocol, blood samples were taken in fasting state.
Results: The results showed that the GLP-1 I and GIP Increased significantly in all experimental group compared to the control group. (Respectively p=0.000 and p=0.000), Also a significant increase in GLP-1 in Momordica charantia+Training compared to the Momordica charantia and GLP-1 in Momordica charantia+Training compared to the Momordica charantia and Training. Other results showed a significant increase in GLP-1 and GIP in all experimental groups compared to pre-tes (p≤0.05).
Conclusion: It seems that aerobic training and Momordica charantia and combination of both, It improves the factors affecting glycemic control in men with type 2 diabetes.

کلیدواژه‌ها [English]

  • Exercise
  • Herbal supplement
  • GLP-1 I and GIP
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