نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 گروه فیزیولوژی ورزشی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران

2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی ، دانشگاه اصفهان، اصفهان، ایران

3 گروه فیزیولوژی ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه شهرکرد، شهرکرد، ایران

چکیده

هدف: میوستاتین و مهار کننده آن فولیستاتین ، عواملی هستند که می توانند به طور بالقوه بیولوژی سالمندی از جمله توده عضلانی را تعدیل نمایند. هدف مطالعه حاضر بررسی تاثیر 12 هفته تمرین مقاومتی با باند‌ کشی بر سطوح سرمی میوستاتین، فولیستاتین در زنان سالمند دارای چاقی استئوسارکوپنیک‌ (OSO) بود.
روش‌ها: در این کارآزمایی بالینی تصادفی شده ‌(RCT) یک سوکور، 48 زن سالمند دارای چاقی سارکوپنیک (بر اساس نتایج آزمایش‌DEXA، سن ‌68/3±13/64 (سال)، درصد‌چربی 56/6±4/45 (درصد)، شاخص‌توده بدنی 71/3±1/33 (کیلوگرم بر متر مربع)، نمره T چگالی مواد معدنی استخوان‌های ران و مهره‌های 1‌ تا 4‌ کمری 42/1±86/1- به دو گروه کنترل (22‌ نفر) و تمرین (26 نفر) تقیسم شدند. گروه تمرین به مدت 12 هفته و سه جلسه در هفته تمرینات مقاومتی با باند‌های کشی را برای همه‌ی گروه‌های عضلانی اصلی انجام دادند. 48 ساعت پیش و پس از 12 هفته مداخله خون‌گیری انجام شد. جهت مقایسه‌های درون گروهی از آزمون‌‌های T وابسته و ویلکاکسون و جهت مقایسه های بین گروهی از آزمون آنکوا استفاده شد.
یافته‌ها: در مقایسه‌نتایج بین گروهی میزان فولیستاتین (002/0P =) در گروه تمرین، وزن (001/0p=) و درصد چربی بدن (001/0p=) افزایش و نسبت فولیستاتین به میوستاتین(۰۱۸/0= P) کاهش معنی داری درگروه کنترل داشت. تفاوت معنی داری در شاخص توده بدنی (054/0P=)، میوستاتین (095/0P=)، مشاهده نشد.
نتیجه‌گیری: به نظر می رسد تمرین مقاومتی با باند‌ کشی استراتژی تمرینی مناسبی باشد که از طریق تعدیل سطوح فولیستاتین و میوستاتین می تواند باعث بهبود ترکیب بدنی و توده عضلانی افراد سالمند دارای چاقی استئوسارکوپنیک‌ می شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of elastic-band resistance training on myostatin, follistatin levels in elderly women with osteosarcopenic obesity

نویسندگان [English]

  • Negin Kazemipour 1
  • Mohammad Faramarzi 2
  • Ebrahim Banitalebi 3

1 departmant of sport physiology, shoushtar Branch, Islamic Azad University, shoushtar, iran

2 Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran

3 Department of Sport Sciences, Shahrekord University, Shahrekord, Iran

چکیده [English]

Purpose: Myostatin, its inhibitor follistatin have been proposed as factors that could potentially modify biological aging. The purpose of this study was to investigate the effect of 12 weeks elastic-band resistance training on myostatin, follistatin levels in elderly women with osteosarcopenic obesity.
Methodology: In this randomized, single blind randomized clinical trial, 48 elderly women with osteosarcopenic obesity (based on the results of the DEXA test, age 64.63 ± 3.68 (years), fat percentage 45.4 ± 6.6 (%), BMI 33.1 ± 3.71 (kg/m2), T score of bone minerals density of femur and 1-4 lumbar spine -1.86 ± 1.42) were randomly divided to control (n = 22) and exercise (n = 26). The training group performed 12 weeks and three sessions a week elastic-band resistance training for all major muscle groups. 48 hours before and after 12 weeks of intervention, blood sampling intervention was performed. Paired-sample t-test was used for intra-group comparisons and Ancova was used for comparison between groups.
Results: The between groups comparison showed the a mount of significant difference in Follistatin (P=0.002) in training group, weight (P = 0.001), fat percentage (P = 0.001) increased and the ratio of follystatin to myostatin (P = 0.018) decreasedsignificantly.incontrol groups. However, there were no significant difference in body mass index (P = 0.054), myostatin (P=0.095) between groups.
Conclusion: Resistance training with elastic band seems to be an appropriate exercise strategy that can improve body composition and muscle mass in elderly people with osteosarcopenic obesity by modulating follistatin and myostatin levels.

کلیدواژه‌ها [English]

  • Osteosarcopenic Obesity
  • Elastic Band Resistance Training
  • Myoststin
  • Folliststin
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