نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
گروه تربیت بدنی، واحد رشت ، دانشگاه آزاد اسلامی ، رشت ، ایران
چکیده
هدف: نوتروفیلها حاوی آنزیم میلوپراکسیداز هستند که با تولید اکسیدانها و کاتالیز اسید هایپوکلروس در بسیاری از فرایند های سلولی نقش دارند. از طرفی، از سنین میانسالی محافظت فیزیولوژیکی بدن در برابر استرس اکسیداتیو شروع به کاستن می کند بنابراین هدف تحقیق حاضر مطالعه تغییرات میلوپراکسیداز و وضعیت تام اکسیدانی در مردان میانسال سالم شرکت کننده در فعالیتهای منظم ورزش همگانی و افراد بدون تمرین است.
روش شناسی: 20 نفر آزمودنی تمرین کرده (سن 94/2 ± 85/53، BMI 6/1 ± 47/25، VO2max 8/2 ± 38/42) و 17 نفر بدون تمرین (سن 83/2 ± 17/54، BMI 12/1 ± 83/27، VO2max 67/1 ± 86/31) در این مطالعه شرکت کردند. آزمودنی ها تست اصلاح شده بروس را به عنوان مدلی از تمرین فزاینده ورزشی انجام دادند. نمونه های خونی قبل، بلافاصله بعد و یک ساعت پس از پایان تست دریافت شد.
یافته ها: در نتایج پیش آزمون میلوپراکسیداز هر دو گروه تغییر معنی داری وجود نداشت، اما این مقادیر بلاقاصله بعد و در دوره ریکاوری، در گروه بدون تمرین نسبت به گروه تمرین کرده تغییر معنی داری داشت. وضعیت تام اکسیدانی در هر دو گروه بلافاصله بعد از تست نسبت به قبل از آن به طور معنی داری افزایش و در دوره ریکاوری کاهش داشت.
نتیجه گیری: شرکت منظم در فعالیتهای ورزش همگانی می تواند باعث کاهش میلوپراکسیداز و ظرفیت تام اکسیدانی مردان میانسال سالم شود و ممکن است روشی مناسب برای داشتن یک زندگی سالم همراه با کاهش نشانگرهای سیستم ایمنی و استرس اکسیداتیو ناشی از افزایش سن در مردان میانسال باشد.
کلیدواژه‌ها
عنوان مقاله [English]
Acute response of myeloperoxidase and total cancer status to increasing exercise activities in trained and non-trained middle-aged men.
نویسندگان [English]
- Seyed Reza Rahimi Moghaddam
- Alireza Elmieh
- Mohammad Reza Fadaei
Department of physical education , rasht branch , Islamic azad university , rasht, Iran
چکیده [English]
Objective: Neutrophils contain myeloperoxidase enzyme, which is involved in many cellular processes by producing oxidants and catalyzing hypochlorous acid. On the other hand, from middle age, physiological protection against oxidative stress starts to decrease. Therefore, the main purpose of this study was to determine myeloperoxidase and total oxidative status changes in healthy trained middle-aged men participating in regular recreational exercise training and untrained subjects.
Methodology: 20 trained (age 53.85±2.94, BMI 25.47±1.6, VO2max 42.38±2.8) and 17 untrained (age 54.17±2.83, BMI 27.83±1.12, VO2max 31.86±1.67) subjects participated in the study. Subjects performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before (T0), immediately after (T1) and one hour after the end of the test (T2).
Results: There was no significant changes in pretest myeloperoxidase level in both groups, but these values were significantly changed in untrained group compared to the trained group at T1 and T2. Total oxidant status levels in both groups increased significantly after completing the test compared to the pretest.
Conclusion: Regular participation in recreational exercise training can reduce the level of myeloperoxidase and total oxidative capacity of healthy middle-aged men, and may be a proper way to have a healthy lifestyle along with reduced immune system and oxidative stress markers caused by aging in middle-aged men.
کلیدواژه‌ها [English]
- Immune system
- Myeloperoxidase
- Total oxidant Status
- Progressive exercise Training
- Middle-aged
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