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لیست داوران سال 1401

لیست داوران سال 1400

اثر تمرین هوازی تداومی و تناوبی همراه با مصرف مکمل سیلیمارین بر میزان آنزیم‌های کبدی و تغییرات بافت کبد در موش‌های صحرایی مبتلا به کبد چرب غیر الکلی القاء شده با دگزامتازون

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.

2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران. قطب علمی پایش سلامت ورزشی و پویش قهرمانی دانشگاه مازندران،

3 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران.

4 دانش آموخته دکتری تخصصی فیزیولوژی، گروه فیزیولوژی، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران

چکیده

هدف: هدف از انجام این مطالعه بررسی تاثیر تمرینات هوازی تداومی و تناوبی شدید همراه با مصرف سیلیمارین بر سطوح سرمی آنزیم‌های کبدی و تغییرات بافت کبد موش‌های صحرایی مبتلا به کبد چرب بود.
روش: در این مطالعه موشهای صحرایی نر پس از تزریق دگزا به 6 گروه مختلف تقسیم شدند: 1-کنترل بیمار 2-سیلیمارین 3- تمرین تناوبی 4- تمرین تناوبی+سیلیمارین 5-تمرین تداومی 6-تمرین تداومی+ سیلیمارین. در گروههای سیلیمارین، 300 میلی-گرم محلول سیلیمارین به ازای هر کیلوگرم از وزن بدن گاواژ شد. گروه‌های تمرینی به مدت 8 هفته تمرین تداومی (54 دقیقه با سرعت 20 متر در دقیقه) و تمرین تناوبی با شدت بالا (6 وهله‌ی 3 دقیقه‌ای با سرعت 40 متر در دقیقه و 3 دقیقه ریکاوری فعال با سرعت 20 متر در دقیقه) با شیب 15 درجه را روی تردمیل انجام دادند.
یافته‌ها: مصرف سیلیمارین و انجام تمرینات ورزشی موجب بهبود تغییرات بافتی در مقایسه با گروه کنترل شد. همچنین اثر تعاملی مصرف مکمل و تمرین بر سطوح AST و ALT معنادار نبود. مصرف سیلیمارین موجب کاهش معنادار سطوح آنزیم AST و ALT شده بود (05/0p≤). سطوح AST در گروه تمرین تناوبی نسبت به گروه کنترل بطور معناداری بالاتر بود (05/0p≤). مقدار این آنزیم در گروه تمرین تناوبی+سیلیمارین نسبت به گروه تمرین تناوبی بطور معناداری کاهش یافته بود (05/0p≤).
نتیجه گیری: مصرف سیلیمارین و تمرین هوازی (تداومی و تناوبی) بصورت مجزا و در ترکیب با یکدیگر می‌تواند موجب بهبود وضعیت بافت کبد موش‌های صحرایی مبتلا به کبد چرب غیر الکلی القاء شده با دگزامتازون شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of silymarin supplementation and continuous and high intensity interval training on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease

نویسندگان [English]

  • Fateme Mokhtari 1
  • Elahe Talebi Garakani 2
  • Khadije Nasiri 3
  • Abolfazl Akbari 4

1 Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.

2 1. Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran. 2. Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran.

3 Department of Exercise Physiology, Sport Sciences Faculty, University of Mazandaran, Babolsar, Iran.

4 Ph.D. Graduate in Physiology, Department of Physiology, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran

چکیده [English]

Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.
Method: Male rats were initially divided into 2 groups: normal and exposed to dexamethasone. Dexamethasone group were randomly divided into 6 groups. control (C), Silymarin (S), continues training (CT), and continues training+silymarin (CTS), high intensity interval training (HIT), high intensity interval training+Silymarin (HITS). Silymarin groups, received 300 mg. kg-1.d-1 of silymarin solution through gavage. Animals in HIT groups performed 3-min bouts at 40 m/min, interspersed by 3-min active recovery at a running velocity of 20 m/min on a motorized treadmill with 15% incline, repeated six times per session. Continues training groups performed steady state running at the same speed as the active recovery's speed in the HIT group. Liver histological modifications and serum levels of alanine aminotransferase (ALT) and Aspartate transaminase (AST) were measured.
Results: Silymarin consumption and aerobic training were able to improve histological changes compared with control group. Interactive effect of silymarin supplementation and training on AST and ALT levels was not significant. Silymarin reduced liver AST and ALT levels (p≤0.05). Also, AST levels were significantly higher in HIT group than in control group (p≤0.05). The amount of this enzyme in the HITS was significantly reduced compared to HIT group (p≤0.05).
Conclusion: Silymarin supplementation and aerobic training separately and in combination may improve liver histological status of rats with dexamethasone-induced nonalcoholic fatty liver.

کلیدواژه‌ها [English]

  • High Intensity Interval Training
  • Silymarin
  • Aspartate Aminotransferase
  • Alanine Aminotransferase
  • Histology

Publisher: University oF Guilan          Copyright © The Authors

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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سوخت و ساز و فعالیت ورزشی
دوره 11، شماره 1 - شماره پیاپی 1
فروردین 1400
صفحه 19-35
فایل ها
سابقه مقاله
  • تاریخ دریافت: 05 فروردین 1401
  • تاریخ بازنگری: 20 اردیبهشت 1401
  • تاریخ پذیرش: 01 خرداد 1401
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