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لیست داوران سال 1401

لیست داوران سال 1400

اثر تمرینات ترکیبی (اینتروال هوازی و مقاومتی) با دو شدت مختلف بر FGF-21، آنزیمهای کبدی، مقاومت به انسولین و ترکیب بدن در زنان مبتلا به کبد چرب غیر الکلی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 گروه فیزیولوژی ورزش دانشگاه گیلان

2 استادیار دانشکده علوم پزشکی،واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران

چکیده

مقدمه: کبد چرب غیرالکلی (NAFLD) وضعیتی است که در آن تجمع چربی در کبد افزایش می‌یابد. ورزش می‌تواند با جلوگیری از تجمع بیش از حد چربی در کبد به عنوان یک مداخله غیردارویی منجر به بهبود این عارضه و جلوگیری از پیشرفت بیماری‌های مزمن کبدی باشد. هدف تحقیق حاضر مقایسه تاثیر تمرینات ترکیبی با شدتهای متفاوت بر FGF-21، مقاومت به انسولین، آنزیمهای کبدی و ترکیب بدن زنان مبتلا به کبد چرب بود.
مواد و روشها: تعداد 33 زن مبتلا به NAFLD با میانگین سنی 75/7±45/43 سال و شاخص توده بدنی 6±84/32 کیلوگرم بر مترمربع) به صورت تصادفی به سه گروه مساوی تقسیم شدند؛ اینتروال هوازی (AIT) - تمرین مقاومتی (ترکیبی 1)، اینتروال شدید (HIIT) - تمرین مقاومتی (ترکیبی 2) و گروه کنترل. برنامه تمرینی به مدت 12 هفته و 3 جلسه در هفته انجام شد. متغیرهای پژوهش قبل و بعد از دوره تمرینی اندازه گیری شد. داده‌ها با استفاده از آزمون آنالیز واریانس با اندازه‌گیری‌های مکرر (05/0p<) مورد تجزیه و تحلیل قرار گرفتند.
یافته‌ها: نتایج نشان داد شاخص HOMA-IR و FGF-21 سرمی در گروه‌های تمرین ترکیبی در مقایسه با گروه کنترل به‌طور معنی‌داری کاهش یافته بود (05/0>p). در سطوح آنزیمهای ALT و AST، اثر و تفاوت معنی داری مشاهده نشد. همچنین، کاهش معنی‌داری درصد چربی بدن مشاهده شد (05/0>p).
نتیجه‌گیری: به نظر می‌رسد زنان مبتلا به NAFLD احتمالا بتوانند از هر دو شدت تمرین ترکیبی مقاومتی و اینتروال متوسط و شدید به‌عنوان یک راهکار غیردارویی برای کاهش درصد چربی و بهبود مقاومت به انسولین و FGF-21 استفاده کنند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of combined training (aerobic interval and resistive) with two intensity on FGF-21, liver enzymes, insulin resistance and body composition in women with non-alcoholic fatty liver

نویسندگان [English]

  • Fahimeh Mehrabani 1
  • farhad rahmani nia 1
  • Javad Mehrabani 1
  • Nasrin Razavianzadeh 2

1 Department of Exercise Physiology, University of Guilan

2 Department of Medical Sciences, Islamic Azad University, Shahrood Branch, Shahrood, Iran

چکیده [English]

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which the accumulation of fat in the liver increases. Exercise training can improve the condition by preventing excessive accumulation of fat in the liver as a non-pharmacological intervention and preventing the progression of the disease to chronic liver disease. The aim of this study was to compare the effect of combined exercises training with two intensities on FGF-21, insulin resistance, liver enzymes and body composition of women with fatty liver.
Materials and Methods: 33 women with NAFLD with a mean age of 57.7 ± 45.43 years and a body mass index of 84.32 6 6 kg/m2 randomly divided into three equal groups; aerobic interval training (AIT); high intensity interval training (HIIT); and controls. The training program was performed for 12 weeks and 3 sessions per week. The variables were measured before and after the training program. Data were analyzed using analysis of variance with repeated measures (p< 0.05).
Results: The results showed that HOMA-IR index and serum FGF-21 were significantly reduced in the combined training groups compared to the control (p<0.05). No significant effect or difference was observed in ALT and AST enzyme levels. Also, a significant decrease in body fat percentage was observed (p<0.05).
Conclusion: It seems that women with NAFLD are likely to be able to use both combined resistance training intensity and moderate to severe interval as a non-pharmacological solution to reduce fat percentage and improve insulin and FGF-21 resistance.

کلیدواژه‌ها [English]

  • Fatty liver
  • combined exercise
  • insulin resistance
  • fibroblast growth factor
  • aspartate aminotransferase

Publisher: University oF Guilan          Copyright © The Authors

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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سوخت و ساز و فعالیت ورزشی
دوره 11، شماره 1 - شماره پیاپی 1
فروردین 1400
صفحه 19-35
فایل ها
سابقه مقاله
  • تاریخ دریافت: 12 دی 1401
  • تاریخ بازنگری: 29 دی 1401
  • تاریخ پذیرش: 13 بهمن 1401
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