نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 دکتری دانشگاه گیلان
2 دانشگاه گیلان
3 بیمارستان قلبی شهید رجایی
چکیده
پرفشاری خون همانند دیس لیپیدمی از مهمترین بیماریهای قلبی-عروقی است که تمرینات ورزشی می‌تواند اثر پیشگیرانه بر آنها داشته باشد. اثر تمرینات ترکیبی به عنوان یک شیوه تمرینی کارآمد، از روش های نوین برای بهبود سلامت قلبی-عروقی است. هدف پژوهش حاضر اثر تمرینات ترکیبی بر شاخص های التهابی قلب-عروقی، فشار خون و پروفایل لیپیدی در مردان مبتلا به پرفشاری خون بود.
در این پژوهش که با طرح پیش آزمون و پس آزمون همراه با گروه کنترل انجام شد، تعداد 9 نفر (5/4±33/47 سال؛ شاخص توده بدنی 27/5±18/33 کیلوگرم/مترمربع) به عنوان گروه تمرین و 9 نفر به عنوان گروه کنترل (20/3±44/48 سال؛ شاخص توده بدنی 35/5±51/30 کیلوگرم/مترمربع) بطور تصادفی از بین افراد داوطلب انتخاب شدند. تمرین ترکیبی که به مدت 16 هفته برگزار شد، شامل 4 جلسه تمرین هفتگی (2 جلسه هوازی، 2 جلسه مقاومتی پویا) بود. تمرینات هوازی با شدت 40-65 درصد اکسیژن مصرفی بیشینه و تمرینات مقاومتی پویا با شدت 55 درصد تکرار بیشینه و هر کدام به مدت 70 تا 80 دقیقه اجرا شد. نتایج آزمون ANCOVA نشان داد فشار خون سیستولی و دیاستولی گالکتین-3 و اندوتلین-1 پلاسمایی در گروه تمرین ترکیبی پس از تمرینات و همچنین در مقایسه با گروه کنترل به طور معنی‌داری کاهش یافته بود (05/0p<). در بین لیپید های خون، سطح کلسترول به طور معنی‌داری کاهش یافته بود (05/0p<). به‌طور کلی نتایج نشان داد اجرای تمرینات ترکیبی هوازی و مقاومتی، علاوه بر کاهش فشار خون و بهبود وضعیت دیس لیپیدمی، منجر به کاهش بیومارکرهای اثرگذار بر التهاب عروقی و نارسایی قلبی شده است.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The effect of combined exercise training on cardiovascular inflammatory markers, lipid profile and blood pressure in hypertensive men
نویسندگان [English]
- Navid Nateghi 1
- Arsalan Damirchi 2
- Javad Mehrabani 2
- Razhan Piran 3
1 University of Guilan, University Campuse 2
2
3 Shahid Rajaei Hospital
چکیده [English]
Hypertension similar to dyslipidemia is most important cardiovascular diseases that exercise training can have a preventive and therapeutic effect on them. The effect of combined exercise training as an effective method is one of the new ways to combat hypertension and cardiovascular health. The purpose of this study was to investigate the effect of combined exercises training on cardiovascular inflammatory markers and blood pressure in hypertensive men.
In this study that designed with pre-post tests with control group, 9 men (47.33±4.5 years; body mass index 33.18±5.27 kg/m2) as combined training group [COT] and 9 as control group [CON] (48.44±3.20 years; body mass index 30.51±5.35 kg/m2) were randomly selected from volunteers. Combined training (aerobic and resistance) that performed in 16 weeks consisted of 4 sessions per week (2 sessions of aerobic and dynamic resistance training, respectively). Aerobic training with 40-65% maximal oxygen uptake (70-80 minutes) and dynamic resistance training with 55% maximum repetition (70-80 minutes) were performed. Results of ANCOVA test showed that systolic and diastolic blood pressure, galactin-3 and endothelin-1 plasma levels were significantly decreased in the post exercise training group as well as in the control group (p<0.05). In lipid profile, we observed significant decrease in total cholesterol (TChol) in combined exercise training group (p<0.05). It can be concluded that, the results showed that the combination of aerobic and resistance training, in addition to lowering blood pressure and improvement of dyslipidemia in men with hypertension, led to a decrease in biomarkers affecting vascular inflammation and heart failure.
کلیدواژه‌ها [English]
- Hypertension
- lipid profile
- heart failure
- combined exercise
- galectin
Publisher: University oF Guilan Copyright © The Authors
This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
- Ahmadi Asl N, Niknazar S, Farajnia S. Effect of three months exercise on expression of endothelin-1 mRNA in the lung tissue (Persian). Pharmacological Sciences.2008;11(1):59-62.
- Pescatello LS, MacDonald HV, Lamberti L, Johnson BT. Exercise for Hypertention: Prescription Update Integrating Existing Recommendations with Emerging research. Hypertention and the Brain.2015;17:87.
- Tosun A, Bolukbasi N, Cingi E, Beyazova M, Unlu M. Acute effects of a single session of aerobic exercise with or without weightlifting on bone turnover in healthy young women. Modern Rheumatology. 2006; 16(5):300-304.
- Bagheri I, Salami F, Hedayati M, Reisi J. Effect of aerobic training on estrogen, PTH, Calcium, alkalinephosphatase and albumin, in postmenopausal women (persian). Iranian Journal of Ageing. 2009;4(2):26-35.
- De Boer RA, Daniels LB, Maisel AS, et al. State of the Art: Newer biomarkers in heart failure. European Journal of Heart Failure.2015;17(6):559-569.
- Atabakhshian R, Raygan F, Kazerouni F. Galectin-3 in fibrosis and heart failure.Journal of Clinical Exellence(persisn).2014;2(2):36-49.
- Anthony J, Donato A, Delp D.The effect of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovascular Research. 2004;66(16):393-401.
- Carvalho DC, Cliquet A. Response of the arterial blood pressure of quadriplegic patient to treadmill gait training. Brazilian Journal of Medieval and Biological Research. 2005;38(9):1367-373.
- De Souza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka h, et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men.Circulation. 2000;102(12):1351-357.
- Donato P, Giulini NA, Bacchi Modena A, Cicchetti G, Comitini G, Gentile G, et al. Risk factors for high blood pressure in women attending menopause clinics in italy. Eur Menopause J Matur 2006; 53:83-88.
- Erem C. Prevalence of pre-hypertention and hypertention and associated risk factor among Turkish adults: Trabozan hypertention study. J Public Health 2008; 31(1): 47-58.
- Anbarloo HR. Assessment of life style education effect to patient with hypertention on their knowledge snd function in the tearoom Shohada hospital. (Persian). M. Sc thesis of nursing, Islamic Azad University Tehran Medical. 2010; 6.
- Rulxing Y. Prevalence, awareness treatment, control and risk factors of hypertention in the Guangxi Hei Yi.Zhan and Han papulation, hypertention.2006; 29: 423-432.
- Hemmelgarn BR,McAllister FA,Myers MG,McKay DW, Bolli P,Abbott C, et al.The 2005 Canadian Hypertention Education Program recommendations for the management of hypertension: part 1-blood pressure measurement, dianosis and assessment of risk.2005;21(8):645-56.
- Esteghamati A, Meysami A, Khalilzadeh O, Rashidi A Haghazali M, Asgari F, et al. Third nastional Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) in Iran: methods and results on prevalence of diabetes, hypertention, obesity, central obesity, and dyslipidemia.BMC Public Health. 2009; 9:167.
- Martiniuk AL,Lee CM,Lawes CM,Ueshima H,Suh I, Lam TH,et al. Hypertention: its prevalence and population-attributable fraction for mortality from cardiovascular disease in the Asia-Pacific region.2007;25(1):73-79.
- Abou Ezzeddine OF, McKie PM, Dunlay SM. Soluble ST2 in Heart Failure with Preserved Ejection Fraction. 2017; J Am Heart Assoc 6: e004382.
- Qassemian A, Daryanoush F, Ghasemian E, Shakoor E. Responses of endothelin-1 and arterial blood pressure of postmenopausal women to aerobic exercise training (persian). Iranian Journal of Ageing.2016:11(2):368-379
- Mozaffarian D, Benjamin EJ,Go AS, Amett DK, Blaha MJ, Cushman M, et al.Heart disease and stroke statistics-2015 update: a report from the American Heart Association.Circulation.2015;131:e29-e322.
- Emdin M, Vittorini S, Passini C, Clerico A. Old and new biomarkers of Heart failure. European Journal of Heart Failure.2009;11(4):331-335.
- Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol.2001; 153: 242-50.
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