نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 کارشناس ارشد علوم ورزشی ، دانشکده علوم تربیتی و روانشناسی دانشگاه شهید مدنی آذربایجان.
2 گروه فیزیولوژی، دانشکده علوم پایه، دانشگاه شهید مدنی آذربایجان ، ایران.
3 دانشگاه شهید مدنی آذربایجان
چکیده
زمینه و هدف: آلزایمر یک بیماری زوال عصبی است در این بیماری تجمع پلاک های آمیلوئید بتا در مغز، باعث کاهش در تراکم عصبی و حجم هیپوکمپ می‌شود. مطالعه انواع فعالیت ورزشی و یافتن بهترین نوع آن، به عنوان روشی برای کنترل آلزایمر مورد توجه قرار گرفته است. هدف تحقیق حاضر مطالعه اثر شش هفته تمرینات هوازی تداومی بر چگالی نورونی ناحیه CA1 هیپوکمپ و عملکرد حافظه بود. روش تحقیق: تحقیق حاضر به صورت تجربی به اجرا درآمد. جامعه آماری رتهای نر نژاد ویستار با محدوده وزنی 300تا 350 گرم بودند. بدین منظور، تعداد 40 سر رت نر یازده ماهه تهیه شدند و به طور تصادفی به چهار گروه ده تایی شامل گروه بیمار تمرین، بیمار کنترل، سالم تمرین و سالم کنترل تقسیم گردیدند. رت‌‌ها به مدت شش هفته با تکرار پنج جلسه در هر هفته، تمرین‌‌های مربوطه را انجام دادند. 48ساعت پس از آخرین جلسه، بافت برداری از مغز انجام و داده‌‌ها جمع‌‌آوری شد. چگالی نورونی به روش هیستولوژی و عملکرد حافظه با تست تشخیص شی جدید اندازه گیری شدند. با استفاده از روش‌‌های آماری تحلیل واریانس دو راهه در سطح معنی‌‌داری 0/05≥p نتایج استخراج گردید. یافته ها: چگالی نورونی در هیپوکمپ در گروه بیمار تمرین نسبت به گروه بیمار کنترل افزایش چشمگیری داشت. همچنین بهبود عملکرد حافظه در گروه بیمار تمرین نسبت به گروه بیمار کنترل (p=0/004) مشاهده شد. نتیجه گیری: اجرای تمرینات هوازی تداومی در طول شش هفته، باعث افزایش در چگالی نورونی در هیپوکمپ می‌شود و عملکرد حافظه در بیماری آلزایمر را بهبود می‌بخشد.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
Six weeks of continuous aerobic training increases the neuronal density in the CA1 area of the hippocampus and improves memory performance in aged AD model rats
نویسندگان [English]
- Aylar Fathi 1
- simin namvar 2
1 Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran
2 Department of biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
چکیده [English]
Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. The aim of the current research was to study the effect of six weeks of continuous aerobic training on the neuronal density of the hippocampus CA1 region and memory performance.
The current research was carried out experimentally. The statistical population was male Wistar rats with a weight range of 300 to 350 grams. For this purpose, 40 11-month-old male rats were prepared and randomly divided into four groups of 10 including the training patient group, control patient group, healthy training group and healthy control group. The rats performed the relevant exercises for six weeks by repeating five sessions per week. 48 hours after the last session, brain tissue was removed and data were collected. Neuronal density was measured by histological method and memory performance by novel object recognition test. The results were extracted using two-way variance analysis at a significance level of p≥0.05.
Neuron density in the hippocampus in the training patient group increased significantly compared to the control patient group. Also, improvement of memory performance was observed in the training patient group compared to the control patient group (p=0.004). Performing continuous aerobic exercises for six weeks increases the neuronal density in the hippocampus and improves memory function in Alzheimer's disease.
کلیدواژه‌ها [English]
- Alzheimer's
- hippocampal neuron density
- memory
- continuous aerobic exercises
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