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لیست داوران سال 1401

لیست داوران سال 1400

اثر همزمان دو ماه تمرین ترکیبی و مکمل‌یاری تورین بر شاخص‌های BDNF، CRP و IL-6 در رت‌ ویستار دیابتی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 دانشجوی دکتری گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.

2 دانشیار گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.

3 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران

4 استادیار گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.

5 استادیار مرکز تحقیقات علوم داروبی، دانشکده داروسازی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران.

چکیده

تمرین و مکمل ازنقص عملکردBDNF و اختلال درسطوح سرمیCRPو IL-6 ناشی ازدیابت جلوگیری می‌کند.هدف تحقیق تعیین اثرهمزمان دو ماه تمرین ترکیبی و مکمل‌یاری تورین بر شاخصهایBDNF، CRP و IL-6 در رت ویستار دیابتی بود.
دراین مطالعه‌تجربی،30رت صحرایی نرویستار بالغ(300-250 ‌گرمی و سن 6 هفته‌ای)،به صورت تصادفی درگروههای تمرین-مکمل ‌دیابتی (10=n)، کنترل دیابتی (10=n) و کنترل سالم (10=n) قرار گرفتند. برای دیابتی‌کردن، در پایان هشت هفتگی، 55 میلی‌گرم برکیلوگرم وزن بدن استرپتوزوسین(STZ)به روش درون‌صفاقی تزریق شد.گروه تمرین-مکمل دیابتی، دوماه تمرینات ترکیبی هوازی-قدرتی را5باردرهفته(تمرین هوازی با75درصدVo2maxروی نوارگردان وتمرین قدرتی،15صعودازنردبان) انجام دادند.مکمل تورین بصورت محلول1%درآب آشامیدنی روزانه(500میلی‌لیتر)دردسترس رت‌ها قرارگرفت.اندازه گیری سطوح سرمیBDNF، CRP و IL-6، به روش الایزاانجام شد.مقایسه تغییرات بین‌گروهی و درون‌گروهیBDNF، CRP و IL-6، باآزمون ‌آنووای یک‌راهه و تعقیبی توکی انجام شد.سطح معنی‌داری0/05>P درنظر گرفته شد.
پس ازدو ماه تمرین هوازی-قدرتی ومصرف مکمل تورین، سطح BDNF سرم درگروه تمرین-مکمل ‌دیابتی درمقایسه با کنترل‌دیابتی به طور معنی‌داری بیشترشد(0/003=P)؛ درحالیکه در گروه کنترل‌دیابتی درمقایسه با کنترل-سالم به‌ طور معنی‌داری کمتر شد (0/0001=P). سطح CRP سرم در گروه تمرین-مکمل ‌دیابتی در مقایسه با کنترل‌دیابتی به طور معنی‌داری کمترشد(0/0001=P)؛درحالی‌که درگروه کنترل‌دیابتی درمقایسه باکنترل‌سالم به طور معنی‌داری بیشترشد (0/0001=P). میزان IL-6 سرم پس از دو ماه تمرین هوازی-قدرتی و مصرف مکمل تورین در گروه تمرین-مکمل دیابتی در مقایسه با گروه کنترل‌دیابتی و در گروه کنترل‌دیابتی در مقایسه با گروه کنترل‌سالم تغییر معنی‌داری نداشت (0/059=P). با توجه به یافته‌های تحقیق حاضر، دو ماه تمرینات همزمان هوازی- قدرتی و مصرف مکمل تورین جهت افزایش سطح BDNF و کاهش التهاب در افراد دیابتی توصیه می شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The simultaneous effect of two months of combined training and taurine supplementation on BDNF, CRP and IL-6 indices in diabetic rats

نویسندگان [English]

  • Mehdi Pahlevani 1
  • Jabbar Bashiri 2
  • Roghayeh Pouzesh Jadidi 3
  • Rasoul Hashem Kandi Asadi 4
  • Masoomeh Dadkhah 5

1 Phd Student of Sports Physiology, Department of Sports Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

2 Professor Associate of Sports Physiology, Department of Sports Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

3 Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran

4 3. Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

5 Assistant Professor, Pharmaceutical Sciences Research Center, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.

چکیده [English]

Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.
After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.

کلیدواژه‌ها [English]

  • Training-Taurine
  • BDNF
  • CRP
  • IL-6
  • Diabetes
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سوخت و ساز و فعالیت ورزشی
دوره 11، شماره 2 - شماره پیاپی 2
مهر 1400
صفحه 151-169
فایل ها
سابقه مقاله
  • تاریخ دریافت: 09 اسفند 1401
  • تاریخ بازنگری: 21 اسفند 1401
  • تاریخ پذیرش: 21 اسفند 1401
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