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لیست داوران سال 1401

لیست داوران سال 1400

تاثیر یک دوره تمرین‌های تناوبی بر بیان ژن فاکتورهای TNF-α، CRP و IL-10 بافت قلب رت‌های نر دیابتی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 دکتری تخصصی، گروه فیزیولوژی ورزشی ، دانشگاه خوارزمی تهران، تهران، ایران

2 استادیار، گروه فیزیولوژی ورزشی دانشگاه فرهنگیان، پردیس شهید چمران، تهران، ایران

3 دکتری تخصصی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران

4 استادیار، گروه فیزیولوژی ورزشی، دانشکده ادبیات و علوم انسانی زابل، زابل، ایران

چکیده

زمینه و هدف: هدف از مطالعه حاضر بررسی تاثیر یک دوره تمرین تناوبی بر برخی از فاکتورهای التهابی و ضد التهابی بافت قلب موش‌های مبتلا به دیابت نوع دو بود. روش‌شناسی: در این پژوهش، تعداد 60 سر موش صحرایی نر انتخاب شدند و با داروی نیکوتین‌آمید و استریتوزوسین (STZ) دیابتی شده و سپس به طور تصادفی به 6 گروه 10 تایی کنترل، تمرین تناوبی، شم، تمرین تناوبی+سالین، دیابتی و دیابت+تمرین تناوبی تقسیم شدند. رت‌ها در گروه‌های تمرین به مدت 6 هفته و ۵ روز در هفته، برنامه تمرین تناوبی را با استفاده از تردمیل اجرا کردند. تجزیه و تحلیل داده‌ها با آزمون آنالیز واریانس یک‌طرفه در سطح معناداری 05/0P≤ انجام گردید. یافته‌ها: نتایج این تحقیق نشان داد میزان گلوکز خون، TNF-α و CRP در گروه‌های تمرین تناوبی و دیابت+تمرین تناوبی نسبت به گروه‌های کنترل و دیابت کاهش معناداری داشت (به ترتیب 001/0P=، 001/0 P= و 003/0=P) و شاخص مقاومت انسولین تغییر معناداری پیدا نکرد 21/0=P). همچنین میزان IL-10 در گروه‌های تمرین تناوبی و دیابت+تمرین تناوبی به ترتیب نسبت به نسبت به گروه‌های کنترل و دیابت افزایش معناداری داشت(01/0=P). نتیجه‌گیری: نتایج این پژوهش نشان داد می‌توان تمرین تناوبی را به عنوان یک استراتژی درمانی برای کاهش فاکتورهای التهابی TNF-α و CRP و افزایش فاکتور ضدالتهابی IL-10 بافت قلب بیماران دیابتی نوع ۲ استفاده کرد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of a period of intermittent training on gene expression of TNF-α, CRP and IL-10 factors in the heart tissue of diabetic male rats

نویسندگان [English]

  • hamid malekshahiniya 1
  • Roohollah Mohammadi Mirzaei 2
  • Halimeh vahdatpoor 3
  • M Azarniveh 4

1 PhD in Cardiac Exercise Physiology, Faculty of Sports Sciences, Kharazmi University, Tehran, Iran

2 Assistant Professor, Department of Sports Sciences, Farhangian University, Shahid Chamran Campus, Tehran, Iran

3 Phd Exercise Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran

4 Assistant Professor, Department of Sports Physiology, Faculty of Literature and Human Sciences, Zabol, Zabol, Iran.

چکیده [English]

Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients.

کلیدواژه‌ها [English]

  • type 2 diabetes
  • heart
  • interval training
  • inflammatory factors
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سوخت و ساز و فعالیت ورزشی
دوره 11، شماره 2 - شماره پیاپی 2
مهر 1400
صفحه 183-201
فایل ها
سابقه مقاله
  • تاریخ دریافت: 10 اسفند 1401
  • تاریخ بازنگری: 27 اسفند 1401
  • تاریخ پذیرش: 28 اسفند 1401
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