نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
نویسندگان
1 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه آیت الله العظمی بروجردی (ره)، بروجرد، ایران
2 دانشیار، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرم‌آباد، ایران
3 کارشناس ارشد تربیت بدنی و علوم ورزشی، اداره آموزش و پرورش ناحیه دو تبریز، تبریز، ایران
4 دکتری علوم تربیتی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران
چکیده
مقدمه: یکی از عوارض یائسگی که در کاهش کیفیـت زنــدگی نقش مهمی دارد کاهش تودة بدون چربی بدن می باشد. هدف از این مطالعه بررسی تاثیر 12 هفته ویبریشن کل بدن بر سطوح سرمی فولیستاتین و مایواستاتین در زنان یائسه بود. روش پژوهش: در این مطالعه نیمهتجربی 20 زن یائسه با کم کاری تیروئید 46 تا 57 ساله شهرستان خرم آباد انتخاب و به دو گروه 10 نفره: کنترل(C) و تمرین ویبریشن کل بدن(V) ، تقسیم شدند. گروهV ، تمرینات را به مدت 12 هفته و سه بار در هفته، با فرکانس 30 تا 50 هرتز، با دامنه یک تا دو میلیمتر با اعمال 20 تا 30 دقیقه ویبریشن 5 تا 15 دقیقه تمرین اندام فوقانی و تحتانی را انجام دادند. ۴۸ ساعت پیش و پس از برنامه تمرینی؛ نمونه گیری خونی و شاخصهای تن سنجی اندازه گیری شد. برای اندازهگیری سطوح سرمی فولیستاتین و مایواستاتین از روش الایزا استفاده شد. داده‌ها با استفاده از آزمون های t مستقل و کوواریانس در سطح معناداری 05/0 >p تجزیه و تحلیل شدند. یافته‌ها: نتایج نشان داد 12 هفته تمرین ویبریشن کل بدن باعث کاهش معناداری در میزان درصد چربی بدن (041/0P=)، شاخص توده بدن (044/0P=) و وزن (047/0P=) همچنین افزایش معنادار سطوح سرمی فولیستاتین (001/0P=) و کاهش مایواستاتین سرم (018/0P=) شد. نتیجه‌گیری: به نظر می‌رسد تمرین ویبریشن کل بدن موجب افزایش سطوح سرمی فولیستاتین و کاهش مایواستاتین در زنان یائسه می شود و این تغییرات مثبت ممکن است در بهبود توده بدون چربی زنان یائسه نقش مهمی ایفا کند.
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
The Effect of a Whole Body Vibration on myostatin and follistatin Serum in Postmenopausal Women
نویسندگان [English]
- amir khosravi 1
- Vahid Valipour Dehnou 2
- Rima Shayan Nasab 3
- sakine Jafarian 4
1 Assistant Professor، Department of Physical Education and Exercise Science، Faculty of Humanities Ayatollah Ozma Borujerdi University, Borujerd، Iran
2 Department of Sport Sciences, Literature & Human Sciences Faculty, Lorestan University, Khorramabad, Iran
3 MSC of physical Education and Sport Sciences,, Tabriz Education Office District II, Tabriz, Iran
4 PhD of Educational Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
چکیده [English]
Introduction: One of the complications of menopause that plays an important role in reducing the quality of life is the reduction of body fat-free mass. The aim of this study was to determine the effect of a period of whole body vibration course on myostatin and follistatin Serum in Postmenopausal Women. Methodology: In this semi experimental study, 20 postmenopausal women with hypothyroidism were selected and divided into two groups of 10: control (C) and whole body vibration training (V). Group V performed these exercises for 12 weeks and three times a week, with a frequency of 30 to 50 Hz, applying on upper and lower limb training. At the beginning and end of the study, blood serum myostatin and follistatin levels were measured using the ELISA method, , body fat percentage, body mass index, and body weight. Due to the normality of data distribution, independent t and covariance statistical methods were used for analysis at a significance level of 0.05. Results: 12 weeks of whole body vibration training in group V significantly increased the serum levels of follistatin (P=0.001), and decreased myostatine (P=0.018) compared to the control group. There was also a significant decrease in body fat percentage (P=0.041), body mass index (P=0.044) and weight (P=0.047). Conclusion: It seems that whole body vibration training increases serum levels of follistatin and decreases myostatin in postmenopausal women, and these positive changes may play an important role in improving lean mass of postmenopausal women.
کلیدواژه‌ها [English]
- Vibration
- myostatin
- follistatin
- Postmenopausal
- Women
- Makara-Studzińśka MT, Kryś-Noszczyk KM, Jakiel G. Epidemiology of the symptoms of menopause–an intercontinental review. Przeglad menopauzalny= Menopause review. 2014;13(3):203.
- Makara-Studzińśka MT, Kryś-Noszczyk KM, Jakiel G. Epidemiology of the symptoms of menopause–an intercontinental review. Menopause Review/Przegląd Menopauzalny. 2014;13(3):203-11.
- Lambrinoudaki I, Armeni E, Goulis D, Bretz S, Ceausu I, Durmusoglu F, et al. Menopause, wellbeing and health: A care pathway from the European Menopause and Andropause Society. Maturitas. 2022;163:1-14.
- Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T. Menopause: a cardiometabolic transition. The Lancet Diabetes & Endocrinology. 2022.
- Abdnezhad R, Simbar M. A review of the effective herbal medicines on hot flashes in menopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2020;23(8):107-19.
- Girardi F, Taleb A, Ebrahimi M, Datye A, Gamage DG, Peccate C, et al. TGFβ signaling curbs cell fusion and muscle regeneration. Nature Communications. 2021;12(1):750.
- Klein GL. Transforming growth factor-beta in skeletal muscle wasting. International journal of molecular sciences. 2022;23(3):1167.
- Mázala DA, Novak JS, Hogarth MW, Nearing M, Adusumalli P, Tully CB, et al. TGF-β–driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. JCI insight. 2020;5(6).
- Choi SJ, Lee MS, Kang D-H, Ko GJ, Lim H-S, Yu BC, et al. Myostatin/appendicular skeletal muscle mass (Asm) ratio, not myostatin, is associated with low handgrip strength in community-dwelling older women. International journal of environmental research and public health. 2021;18(14):7344.
- Rodgers BD, Ward CW. Myostatin/activin receptor ligands in muscle and the development status of attenuating drugs. Endocrine Reviews. 2022;43(2):329-65.
- Grevendonk L, Connell NJ, McCrum C, Fealy CE, Bilet L, Bruls YM, et al. Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function. Nature Communications. 2021;12(1):4773.
- Marques DL, Neiva HP, Marinho DA, Marques MC. Manipulating the Resistance Training Volume in Middle-Aged and Older Adults: A Systematic Review with Meta-Analysis of the Effects on Muscle Strength and Size, Muscle Quality, and Functional Capacity. Sports Medicine. 2023;53(2):503-18.
- Scisciola L, Fontanella RA, Surina, Cataldo V, Paolisso G, Barbieri M. Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk. Life. 2021;11(2):173.
- Wu S, Ning H-T, Xiao S-M, Hu M-Y, Wu X-Y, Deng H-W, et al. Effects of vibration therapy on muscle mass, muscle strength and physical function in older adults with sarcopenia: a systematic review and meta-analysis. European Review of Aging and Physical Activity. 2020;17:1-12.
- Hettchen M, von Stengel S, Kohl M, Murphy MH, Shojaa M, Ghasemikaram M, et al. Changes in menopausal risk factors in early postmenopausal osteopenic women after 13 months of high-intensity exercise: The randomized controlled ACTLIFE-RCT. Clinical Interventions in Aging. 2021;16:83.
- Attarzadeh Hosseini SR, Moeinnia N, Motahari Rad M. The effect of two intensities resistance training on muscle growth regulatory myokines in sedentary young women. Obesity Medicine. 2017;5.
- Negaresh R, Ranjbar R, Baker JS, Habibi A, Mokhtarzade M, Gharibvand MM, et al. Skeletal muscle hypertrophy, insulin-like growth factor 1, myostatin and follistatin in healthy and sarcopenic elderly men: the effect of whole-body resistance training. International journal of preventive medicine. 2019;10.
- Nordlund M, Thorstensson A. Strength training effects of whole‐body vibration? Scandinavian journal of medicine & science in sports. 2007;17(1):12-7.
- Ma C, Liu A, Sun M, Zhu H, Wu H. Effect of whole-body vibration on reduction of bone loss and fall prevention in postmenopausal women: a meta-analysis and systematic review. Journal of orthopaedic surgery and research. 2016;11(1):24.
- Lu L, He X, Ma L, Liu Y, Chen N. Effects of vibration training vs. conventional resistance training among community-dwelling older people with sarcopenia: three-arm randomized controlled trial protocol. Frontiers in Aging Neuroscience. 2022;14:905460.
- Blanks AM, Rodriguez-Miguelez P, Looney J, Tucker MA, Jeong J, Thomas J, et al. Whole body vibration elicits differential immune and metabolic responses in obese and normal weight individuals. Brain, Behavior, & Immunity-Health. 2020;1:100011.
- Khosravi A, Taherzadeh S. The Effect of a Whole Body Vibration Period on Serum BDNF Levels in Obese Postmenopausal Women. Journal of Applied Health Studies in Sport Physiology. 2022;9(2):81-92.
- Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British journal of nutrition. 1978;40(3):497-504.
- Jensky NE, Sims JK, Dieli-Conwright CM, Sattler FR, Rice JC, Schroeder ET. Exercise does not influence myostatin and follistatin mRNA expression in young women. Journal of strength and conditioning research/National Strength & Conditioning Association. 2010;24(2):522.
- Mafi F, Biglari S, Afousi AG, Gaeini AA. Improvement in skeletal muscle strength and plasma levels of follistatin and myostatin induced by an 8-week resistance training and epicatechin supplementation in sarcopenic older adults. Journal of aging and physical activity. 2019;27(3):384-91.
- Khalafi M, Aria B, Symonds ME, Rosenkranz SK. The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis. Physiology & Behavior. 2023:114272.
- Lim C, Nunes EA, Currier BS, Mcleod JC, Thomas AC, Phillips SM. An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy. Medicine and science in sports and exercise. 2022;54(9):1546.
- McIntosh MC, Sexton CL, Godwin JS, Ruple BA, Michel JM, Plotkin DL, et al. Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers. Cells. 2023;12(6):898.
- Dalbo V, Roberts M, Mobley C, Ballmann C, Kephart W, Fox C, et al. Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle. Andrologia. 2017;49(3):e12622.
- Paris MT, Bell KE, Mourtzakis M. Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise. Current opinion in pharmacology. 2020;52:61-6.
- Allen DL, Hittel DS, McPherron AC. Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Medicine and science in sports and exercise. 2011;43(10):1828.
- Wang Z, Wei Z, Li X, Lai Z, Wang L. Effect of whole-body vibration on neuromuscular activation and explosive power of lower limb: A systematic review and meta-analysis. Plos one. 2022;17(12):e0278637.
- Monteiro-Oliveira BB, Coelho-Oliveira AC, Paineiras-Domingos LL, Sonza A, Sá-Caputo DdCd, Bernardo-Filho M. Use of surface electromyography to evaluate effects of whole-body vibration exercises on neuromuscular activation and muscle strength in the elderly: a systematic review. Disability and Rehabilitation. 2022;44(24):7368-77.
- Han X, Møller LLV, De Groote E, Bojsen‐Møller KN, Davey J, Henríquez‐Olguin C, et al. Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle. 2019;10(6):1241-57.
)