Exercise Physiology
Maryam Belbasi; Asieh Abbassi Daloii; Ahmad Abdi
Abstract
Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) ...
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Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) and Adipocyte fatty acid-binding protein (A-FABP) levels of adipose tissue in type 2 diabetic obese rats. Method: To implementation of this experimental research, 32 obese male wistar rats (weight 320±20 gr) randomly were divided into 4 groups including obese control, shem (obese), obese diabetic, obese diabetic - high-intensity interval training. Intraperitoneal injection of nicotinamide amide-streptozotocin was used to induction type 2 diabetes. high-intensity interval training program was performed 4 days a week for six weeks. VEGF-A and A-FABP levels in rat adipose tissue were measured using by ELISA kit. Results: the VEGF-A level in adipose tissue in the obese diabetic group was significantly lower than the obese control group (P=0.001). Also, A-FABP (P=0.001) and insulin resistance (P=0.004) was significantly higher in the obese diabetic group than the obese control groups. High-intensity interval training was associated with significant increase of VEGF-A and decrease A-FABP levels in adipose tissue and insulin resistance in obese diabetic rats (P=0.001). Conclusion: It seems that high-intensity interval training can help improve adipose tissue metabolic parameters and insulin resistance in obese diabetic rats.
Exercise Physiology
Seyede fateme motavalli; alireza barari; ahmad abdi; hosein abed natanzi
Abstract
Introduction: The aim of this study was to evaluate the effect of nettle extract consumption and aerobic exercise on VEGF and caspase 3 gene expression in mice with melanoma.Methodology: In this study, 20 adult male rats with age of 8 week were randomly divided into 4 groups including: control, exercise, ...
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Introduction: The aim of this study was to evaluate the effect of nettle extract consumption and aerobic exercise on VEGF and caspase 3 gene expression in mice with melanoma.Methodology: In this study, 20 adult male rats with age of 8 week were randomly divided into 4 groups including: control, exercise, extract and exercise + extract. The training program consisted of 30 minutes of running on a treadmill without a slope at a speed of 16 m/min for the first week, and one meter per minute was added every week until it reached 22 meters per minute in the eighth week. One week after melanoma induction, the experimental group consumed 30 mg /kg /day of nettle ethanol extract orally for 8 weeks. RT PCR in blood was used to measure the expression of VEGF and caspase 3 genes.Results: Data analysis showed that VEGF gene expression was decreased in experimental groups compared to the control group; But did not reach a significant level (p = 0.154). The results also showed that caspase 3 gene expression was significantly increased in the experimental groups compared to the control group (p = 0.000). Post hoc test also showed that caspase 3 gene expression was significantly different between the combination group and other groups.Conclusion: The results showed that consumption of nettle extract may have anti-cancer effects through various mechanisms such as antioxidant activity, induction of apoptosis inhibition of cell growth and cell migration.
Exercise Physiology
Ghasem Torabi Palat Kaleh; Ahmad Abdi; Asieh Abbassi Daloii
Abstract
Aim: Heart performance declines with age and obesity. Aging and obesity a major risk factor toward the development of cardiovascular diseases (CVDs). The aging heart undergoes several changes at the molecular, cellular and physiological levels, which diminishes its contractile function. The aim of the ...
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Aim: Heart performance declines with age and obesity. Aging and obesity a major risk factor toward the development of cardiovascular diseases (CVDs). The aging heart undergoes several changes at the molecular, cellular and physiological levels, which diminishes its contractile function. The aim of the present study was to investigate the effect of aerobic training and omega-3 on atrophy indices in the cardiomyocytes of elderly HFD rats. Methods: In this experimental study, 40 male Wistar rats (mean weight 148.82±18.24) were divided into 5 groups: Normal Diet (ND), High-Fat Diet (HFD), High-Fat Diet-Training (HFDT), High-Fat Diet-Omega3 (HFDω3) and High-Fat Diet-Training-Omega3 (HFDTω3). The supplement groups received 1 g of Omega3 (per kg of body weight) orally during the intervention period. Aerobic exercise program including running on treadmill with an intensity of 50-60% oxygen consumption (VO2max), was performed 5 days a week for eight weeks. Data were analyzed by one-way analysis of variance and Tukey post hoc test at the P<0.05. Results: Significant decrease were seen in FoxO3a, MAFbx, and MuRF1 gene expression levels in HFDT (p=0.039, p=0.016, and p=0.043, respectively), HFDω3 (p=0.035, p=0.044, p=0.030, respectively), and HFDTω3 (p=0.0001, p=0.0001 and p=0.0001 respectively). Also, a significant decrease in FoxO3a expression was observed in the HFDTω3 group compared to HFDT (P=0.040) and HFDω3 (P=0.045). Conclusion: Aerobic training and omega-3 protected against HFD-induced cardiac atrophy in elderly rats, however, the combined effect of aerobic exercise and omega-3 was better.
Maryam Mostafavian; Ahmad Abdi; Javad Mehrabani; Alireza Barari
Abstract
Aim: Converting white adipose tissue (WAT) to brown adipose tissue (BAT) is therapeutic potential to combat obesity. The purpose of this study was to investigate the effects of aerobic training and capsaicin (Cap) on FNDC5 gene expression and irisin protein level of visceral adipose tissue in rat fed ...
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Aim: Converting white adipose tissue (WAT) to brown adipose tissue (BAT) is therapeutic potential to combat obesity. The purpose of this study was to investigate the effects of aerobic training and capsaicin (Cap) on FNDC5 gene expression and irisin protein level of visceral adipose tissue in rat fed a high-fat diet (HFD).Methods: 40 male Wistar rats were fed a normal diet (ND, n = 8) or HFD (n = 32) for 8 weeks. After 8 weeks, all rats were divided into 5 groups: ND, HFD, high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups have performed a progressive aerobic running program (at 15-25 m/min, 30-60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) were administered orally, by gavage, once a day. Results: The results of this study showed that FNDC5 expression (p=0.001) and irisin (p=0.000) was decreased in HFD group compared to ND group. Also, the expression of FNDC5 and irisin in HFDT (Respectively p=0.006, p=0.020), HFDCap (Respectively p=0.005, p=0.021) and HFDTCap (Respectively p=0.000, p=0.000) groups was significantly increased compared to HFD. The expression of FNDC5 and irisin in HFDTCap was also significantly increased compared to HFDT (Respectively p=0.037, p=0.035) and HFDCap (Respectively p=0.044, p=0.033) groups.Conclusions: Aerobic training combination with capsaicin with increased FNDC5 and irisin in visceral adipose tissue, had Interactive effects on factors affecting browning of adipose tissue.
O Mohajer Iravani; A Abdi; A Abbassi Daloii
Abstract
Aim: : In type 2 diabetes patients, the level of incretins is reduced. Incretins play an important role in glucose homeostasis. The aim of this study was to examine the effect of aerobic training along with Momordica charantia L on serum incretin levels in man with type 2 diabetes.
Method: In this study, ...
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Aim: : In type 2 diabetes patients, the level of incretins is reduced. Incretins play an important role in glucose homeostasis. The aim of this study was to examine the effect of aerobic training along with Momordica charantia L on serum incretin levels in man with type 2 diabetes.
Method: In this study, 36 men with type 2 diabetes (age 53.08±5.15 years, wight 78.08±6.53kg and BMI 26.22±1.2218 kg/square meters) were selected and were randomly divided into four groups (Control-Water, Control-Momordica charantia, Control-Training and Momordica charantia+Training). The training groups participated in a progressive aerobic training for eight weeks, three sessions a week (running with 40% to 70% of the reserved heart rate and for 15 to 45 min). The groups of Control-Momordica charantia and Momordica charantia+Training were provided 2000 mg of Momordica charantia (In 500 mg capsules) for eight weeks (Twice a day before breakfast and dinner). Two days before and after the protocol, blood samples were taken in fasting state.
Results: The results showed that the GLP-1 I and GIP Increased significantly in all experimental group compared to the control group. (Respectively p=0.000 and p=0.000), Also a significant increase in GLP-1 in Momordica charantia+Training compared to the Momordica charantia and GLP-1 in Momordica charantia+Training compared to the Momordica charantia and Training. Other results showed a significant increase in GLP-1 and GIP in all experimental groups compared to pre-tes (p≤0.05).
Conclusion: It seems that aerobic training and Momordica charantia and combination of both, It improves the factors affecting glycemic control in men with type 2 diabetes.
B Esmaeili; A Abdi; J Mehrabani
Abstract
Aim: Lipocalin-2 and interleukin-1 beta (IL-1ß) are two inflammatory markers affecting on insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on blood levels of Lipocalin-2 and IL-1ß in insulin-resistant rats. Method: : In this ...
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Aim: Lipocalin-2 and interleukin-1 beta (IL-1ß) are two inflammatory markers affecting on insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on blood levels of Lipocalin-2 and IL-1ß in insulin-resistant rats. Method: : In this experimental study thirty-six Wistar male rats were randomly divided into four groups: control (n=9), aerobic training (n=9), cinnamon (n=9), and aerobic training+cinnamon (n=9). Insulin-resistance status induced by %10 fructose solutions during 5 weeks. Training groups subjected to a 5-day per week aerobic training program (with 75-80% VO2max) for 8 weeks. Supplementayion groups subjected to injected 200 ml/kg/day cinnamon extract. Results: Exercise training significantly reduced Lipocalin-2 compared to the control group, and compared to extract group (P<0.05). Also, in all three experimental groups, IL-1 beta decreased significantly compared to control (P<0.05), and significant decrease was observed in the extract group compared to the training group and extract (PConclusion: Results of this study indicated that aerobic training with cinnamon extract more than any of them alone effects on reduction IL-1ß. But the effect of the combination of aerobic training and cinnamon extract on lipocalin-2 requires further investigation.
A Abdi; M Nasiri; A Abbasi
Abstract
Aim: Exercise training represents a successful and powerful strategy to prevent future cardiovascular disease. However, Studies have shown that acute exercise can increase serum concentrations of cardiac biomarkers. The aim of this study was to investigate the effects of a session wrestling match with ...
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Aim: Exercise training represents a successful and powerful strategy to prevent future cardiovascular disease. However, Studies have shown that acute exercise can increase serum concentrations of cardiac biomarkers. The aim of this study was to investigate the effects of a session wrestling match with beta-alanine supplementation on some indicators of heart damage in elite wrestlers. Methods: 16 wrestlers as subjects (two men in each weight) were selected and purposefully they were divided into control and experimental groups. Supplement group consumption 1000 mg beta-alanine for 4 hours before the protocol. The training program includes a course of the match was simulated, the wrestler held four wrestling match at intervals of half-hour. The amount of 8 ml blood samples from the brachial vein before, immediately after and one hour after the exercise program were collected. Data were analyzed with using of t test and analysis of variance with repeated measures at αResults: The results showed that a session of wrestling match with beta-alanine supplementation had no significant effect on troponin I and troponin T (P=0.05). a session of wrestling match with beta-alanine supplementation were significantly increased CKmb and LDH (P=0.000). Conclusion: It seems indicators damage the heart (cardiac troponin I and T) to follow the intense activity and beta-alanine supplementation does not change in athletes with high fitness.
Ahmad Abdi; Nasrin Ramezani; Hasan Haji
Volume 5, Issue 1 , June 2015, , Pages 59-68
Abstract
Aim: Oxidative stress is an affective factor in insulin resistant, diabetes and other problems increasing blood glucose that seen in type 1 and 2 diabetes is an effective factor in producing oxidative stress. The aim of this study was to evaluate the effect of resistance training and Coriandrum sativum ...
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Aim: Oxidative stress is an affective factor in insulin resistant, diabetes and other problems increasing blood glucose that seen in type 1 and 2 diabetes is an effective factor in producing oxidative stress. The aim of this study was to evaluate the effect of resistance training and Coriandrum sativum on oxidative stress factors in diabetic male rats. Method: The present experimental study was conducted on 40 adult male rats. After induction of diabetes, the rats were randomly divided into four equal groups (1: resistance training, 2: resistance training-Coriandrum sativum extract, 3: Coriandrum sativum extract, and 4: control). Diabetic condition was induced by using 55 mg af streptozotosin per one kg body weight. Then they performed 6 weeks of resistance training (five days a week for 6 weeks and with intensity of 30-100% rats weight) and drank oral Coriandrum sativum extract (150 mg/kg daily). After 6 weeks serum levels of total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) were measured. Results: The results showed that resistance training alonge with Coriandrum sativum extract increased serum levels of TAC, SOD and CAT (p<0.05) significantly. Also, TAC level was increased in resistance and Coriandrum sativum extract groups (p<0.05). Conclusion: It seems that six weeks at resistance training combined with Coriandrum sativum extract may have a positive effect on body anti-oxidant system and treatment of diabetes.
