Exercise Physiology
faeghe ghasemi; Hamid Mohebbi
Abstract
Background: The aim of this study was to determine the effect of nutrition, training and hypoxia on liver mitochondrial biogenesis in male Wistar rats. Methods: Thirty-two male rats (age: 6 weeks old; average weight: 167.25 grams (were randomly divided into four groups of eight including normal diet ...
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Background: The aim of this study was to determine the effect of nutrition, training and hypoxia on liver mitochondrial biogenesis in male Wistar rats. Methods: Thirty-two male rats (age: 6 weeks old; average weight: 167.25 grams (were randomly divided into four groups of eight including normal diet (ND), high-fat diet (HFD), high-fat diet and training in normoxia (HFD-HIIT) and high-fat diet and training in hypoxia (HFD-HHIIT). After determining the maximum aerobic velocity (MAV) in normoxia and hypoxia-hypobaric, the HIIT protocol was performed for 12 weeks and three sessions per week, which included 3 to 8 bouts 4-minute activity with an intensity of 80 to 93 percent of MAV and 2-minute active rest periods with an intensity of 50 percent of MAV. At the end, the levels of PGC-1α and Tfam genes were measured through RT-PCR . Results: Both HFD-HIIT and HFD-HHIIT groups showed a significant increase in the expression of PGC-1α and Tfam genes and a significant decrease in liver fat content compared to the HFD group (p<0.05). However, the HFD+HHIIT group showed a significant increase in Tfam gene expression and a significant decrease in liver fat content compared to the HFD+HIIT group (p<0.05). Conclusions: It seems that HIIT training has been able to increase PGC-1α independent of hypoxia conditions. Whereas, hypoxia with a significant increase in the expression of the Tfam gene, which plays a role in improving the capacity of mitochondrial function, led to a greater decrease in liver fat content than in normoxia conditions.
Response and adaptation to exercises
Mostafa Haghshenas; Alireza Elmiyeh; Mohammadreza Fadaei chafe
Abstract
Alzheimer's is the most common age-related disease. The symptom of the disease is the formation of beta amyloid plaques outside the cell and interwoven filaments inside the neuron consisting of filaments containing the phosphorylated form of tau microtubule protein. Neurotrophic factors are widely expressed ...
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Alzheimer's is the most common age-related disease. The symptom of the disease is the formation of beta amyloid plaques outside the cell and interwoven filaments inside the neuron consisting of filaments containing the phosphorylated form of tau microtubule protein. Neurotrophic factors are widely expressed in the brain, but are greatly reduced in the brain of Alzheimer's patients. The aim of this study was to investigate the effect of aerobic exercise with olive oil on the expression of caspase genes in Alzheimer's rats.In this study, 40 adult rats were randomly divided into 5 control groups, Alzheimer's, Alzheimer's and aerobic exercise, Alzheimer's, aerobic exercise and olive oil, Alzheimer's and olive oil. Alzheimer's model was created by injecting amyloid beta 1-42 in the hippocampus and training was performed 3 times a week for 8 weeks. Real time PCR method was used to determine the expression level of the desired genes. To analyze the data, one-way analysis of variance and Tom Hahn's post hoc test were used.
