اثر هشت هفته تمرین هوازی همراه با مکمل‌یاری عصاره دارچین بر لیپوکالین-2 و IL-1ß در موش های صحرایی‌های مقاوم به انسولین

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشجوی فیزیولوژی ورزشی

2 استادیار دانشگاه آزاد اسلامی واحد آیت الله آملی

3 استادیار دانشگاه گیلان

چکیده

هدف: لیپوکالین-2 و اینترلوکین-1بتا (IL-1ß) از عوامل التهابی موثر بر مقاومت به انسولین می‌باشند. هدف از پژوهش حاضر ارزیابی اثر تمرین هوازی همراه با مکمل عصاره دارچین بر سطوح خونی لیپوکالین-2 و IL-1ß در موش‌های مقاوم به انسولین می‌باشد.
روش‌شناسی: در این مطالعه تجربی 36 سر موش صحرایی نر نژاد ویستار  به طور تصادفی به چهار گروه (کنترل (9=n)، تمرین هوازی (9=n)، عصاره دارچین (9=n) و تمرین هوازی+ عصاره دارچین (9=n)) تقسیم شدند. القای مقاومت به انسولین با استفاده از محلول فروکتوز 10 درصد به مدت 5 هفته انجام شد. گروه های تمرین پنج روز در هفته ( با شدت 75-80 درصد حداکثر اکسیژن مصرفی) به مدت 8 هفته تمرین هوازی را انجام دادند. به گروه های مکما یاری 200 میلی گرم به ازای هر کیلوگرم وزن بدن در روز عصاره دارچین، تزریق شد. داده ها با استفاده از آنالیز واریانس یک طرفه در سطح معنی­داری 05/0 p≤ تحلیل شد.
یافته‌ها: کاهش معنی‌داری در میزان لیپوکالین-2 گروه تمرین نسبت به گروه کنترل و نسبت به گروه عصاره دارچین مشاهده شد (05/0>p). همچنین در هر سه گروه تجربی، میزان IL-1ß نسبت به گروه کنترل کاهش معنی‌داری را نشان داد (05/0>P)، و کاهش معنی داری در گروه تمرین عصاره دارچین نسبت به گروه تمرین و عصاره مشاهده شد (05/0>p)..
نتیجه‌گیری: نتیجه پژوهش حاضر نشان داد که تمرین هوازی  همراه با عصاره دارچین بیشتر از هر کدام به تنهایی بر کاهش IL-1ß  اثر دارد.  اما اثر ترکیب تمرین هوازی و عصاره دارچین بر  لیپوکالین-2 نیاز به بررسی های بیشتری دارد.
 

کلیدواژه‌ها


عنوان مقاله [English]

Effect of 8 weeks aerobic training with cinnamon extract supplementation on Lipocalin-2 and IL-1ß in insulin-resistant rats

نویسندگان [English]

  • B Esmaeili 1
  • A Abdi 2
  • J Mehrabani 3
1 MSc student in exercise physiology
2 Assitant Professor, Ayatollah Amoli Branch, Islamic Azad University
3 Assitant Professor, Gilan Univercity
چکیده [English]

Aim: Lipocalin-2 and interleukin-1 beta (IL-1ß) are two inflammatory markers affecting on insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on blood levels of Lipocalin-2 and IL-1ß in insulin-resistant rats.
Method: : In this experimental study thirty-six Wistar male rats were randomly divided into four groups: control (n=9), aerobic training (n=9), cinnamon (n=9), and aerobic training+cinnamon (n=9). Insulin-resistance status induced by %10 fructose solutions during 5 weeks. Training groups subjected to a 5-day per week aerobic training program (with 75-80% VO2max) for 8 weeks. Supplementayion groups subjected to injected 200 ml/kg/day cinnamon extract.
Results: Exercise training significantly reduced Lipocalin-2 compared to the control group, and compared to extract group (P<0.05). Also, in all three experimental groups, IL-1 beta decreased significantly compared to control (P<0.05), and significant decrease was observed in the extract group compared to the training group and extract (PConclusion: Results of this study indicated that aerobic training with cinnamon extract more than any of them alone effects on reduction IL-1ß. But the effect of the combination of aerobic training and cinnamon extract on lipocalin-2 requires further investigation.
 

کلیدواژه‌ها [English]

  • Keywords: Aerobic exercise
  • Cinnamon extract
  • Lipocalin-2 and IL-1ß
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