Exercise Physiology
faeghe ghasemi; Hamid Mohebbi
Abstract
Background and Purpose: Consuming a high-fat diet leads to disruption of liver mitochondrial biogenesis. Training exercise and hypoxia, which are new preventive or therapeutic strategies for obesity-induced NAFLD, may improve the impaired mitochondrial function. The aim of this study was to determine ...
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Background and Purpose: Consuming a high-fat diet leads to disruption of liver mitochondrial biogenesis. Training exercise and hypoxia, which are new preventive or therapeutic strategies for obesity-induced NAFLD, may improve the impaired mitochondrial function. The aim of this study was to determine the effect of nutrition, training and hypoxia on liver mitochondrial biogenesis in male Wistar rats. Methods: Thirty-two male rats (age: 6 weeks old; average weight: 167.25 grams) were randomly divided into four groups of eight including normal diet (ND), high-fat diet (HFD), high-fat diet and training in normoxia (HFD-HIIT) and high-fat diet and training in hypoxia (HFD-HHIIT). After determining the maximum aerobic velocity (MAV) in normoxia and hypoxia-hypobaric, the HIIT protocol was performed for 12 weeks and three sessions per week, which included 3 to 8 bouts 4-minute activity with an intensity of 80 to 93 percent of MAV and 2-minute active rest periods with an intensity of 50 percent of MAV. At the end, the levels of PGC-1α and Tfam genes were measured through RT-PCR. Results: Both HFD-HIIT and HFD-HHIIT groups showed a significant increase in the expression of PGC-1α and Tfam genes and a significant decrease in liver fat content compared to the HFD group (p<0.05). While, there was no significant difference in the expression of these genes between the two training groups. Conclusions: It seems that HIIT training has been able to increase mitochondrial biogenesis and reduce liver fat content independently of hypoxia conditions.
Exercise Physiology
amir khosravi; Vahid Valipour Dehnou; Rima Shayan Nasab; sakine Jafarian
Abstract
Aim: One of the complications of menopause that plays an important role in reducing the quality of life is the reduction of body fat-free mass. The aim of this study was to determine the effect of a period of whole body vibration course on myostatin and follistatin Serum in Postmenopausal Women. Methods: ...
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Aim: One of the complications of menopause that plays an important role in reducing the quality of life is the reduction of body fat-free mass. The aim of this study was to determine the effect of a period of whole body vibration course on myostatin and follistatin Serum in Postmenopausal Women. Methods: In this semi experimental study, 20 postmenopausal women with hypothyroidism were selected and divided into two groups of 10: control (C) and whole body vibration training (V). Group V performed these exercises for 12 weeks and three times a week, with a frequency of 30 to 50 Hz, applying on upper and lower limb training. At the beginning and end of the study, blood serum myostatin and follistatin levels were measured using the ELISA method, , body fat percentage, body mass index, and body weight. Due to the normality of data distribution, independent t and covariance statistical methods were used for analysis at a significance level of 0.05. Results: 12 weeks of whole body vibration training in group V significantly increased the serum levels of follistatin (P=0.001), and decreased myostatine (P=0.018) compared to the control group. There was also a significant decrease in body fat percentage (P=0.041), body mass index (P=0.044) and weight (P=0.047).Conclusions: It seems that whole body vibration training increases serum levels of follistatin and decreases myostatin in postmenopausal women, and these positive changes may play an important role in improving lean mass of postmenopausal women.
Exercise Physiology
Fariba Pourasghar; jabbar bashiri; Roghayeh Pouzesh Jadidi; HASSAN POURRAZI; Mir Alireza Nourazar
Abstract
Aim: The aim of the present study is to investigate the effect of intense interval exercise training and melatonin supplementation on the apoptotic indices of kidney tissue in rats suffering from renal ischemia reperfusion injury. Methods: 30 male Wistar rats (weight: 250 and 300 grams) were randomly ...
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Aim: The aim of the present study is to investigate the effect of intense interval exercise training and melatonin supplementation on the apoptotic indices of kidney tissue in rats suffering from renal ischemia reperfusion injury. Methods: 30 male Wistar rats (weight: 250 and 300 grams) were randomly divided into 5 groups, healthy, Ischemia/Reperfusion (I/R), I/R + intense interval training, I/R + melatonin supplement and I/R + high intensive interval training + melatonin supplement. Except for the healthy group, the animals were subjected to ischemia-reperfusion in other test groups. The high intensive interval training protocol was implemented for 12 weeks (5 days per week). Caspase 3, BAX, BCL2 and TNFα gene expression indices were measured by real time PCR method. Because of the non-normal distribution of parameters, the data were analysed by Kruskal–Wallis, Mann–Whitney and Wilcoxon test at the significance level of p
Exercise Physiology
tahereh shadpour ali zadeh; Mohammad ali Azarbayjani; sirvan atashak; maghsoud peeri; saleh Rahmati ahmad abad
Abstract
AbstractAim:Menopause is associated with an imbalance in the expression of atherogenesis genes in the motor nerve terminal. However, the effect of resistance training on the gene expression affecting the inhibition of sarcopenia in the neurotransmitter plate is not well understood.The purpose of this ...
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AbstractAim:Menopause is associated with an imbalance in the expression of atherogenesis genes in the motor nerve terminal. However, the effect of resistance training on the gene expression affecting the inhibition of sarcopenia in the neurotransmitter plate is not well understood.The purpose of this study was to determine the effect of 8 weeks of increasing resistance training on the gene expression of AKT and mTORC-1 in the motor end plate of the quadriceps muscle of post-menopausal wistar rat.Methods:In this experimental study, 20 female Wistar rats (8 to 12 weeks old) with an average weight of 235 to 265 g, were randomly divided into 2 groups including Resistance Training (RT) and Control (C).Ovariectomy was performed after anesthesia with an intraperitoneal injection of Ketamine/Xylazine mixture with a bilateral incision in the lumbar region. incremental resistance training was performed for 8 weeks, 5 days a week on an 85 degree incline ladder. After 24 hours of the last training session and afterward recovery, animals were sacrificed and their quadriceps muscle was extracted. Real-time PCR was used to determine the expression of AKT and mTORC-1 genes.T-test was used at alpha level of 0.05 to compare the independent groups.Results:Genes expression AKT and Mtorc-1 were increased in the training group compared to the control(P=0.001 and P=0.003 respectively).The rats body weight did not show significant change in any of the groups(P=0.151).Conclusion:It seems that increasing resistance training reduces sarcopenia by increasing the genes expression of AKT and mTORC-1 in the motor end plate.
Exercise Physiology
Maryam Kafi; khadijeh irandoust
Abstract
Introduction: The aim of this study was to evaluate the importance of aerobic exercise and quercetin supplementation on the progression of colon cancer in rats and changes in the effects of IGF1 and myostatin on muscle tissue and the shape of fluctuations in atrophy and muscle wasting. Methods: The subjects ...
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Introduction: The aim of this study was to evaluate the importance of aerobic exercise and quercetin supplementation on the progression of colon cancer in rats and changes in the effects of IGF1 and myostatin on muscle tissue and the shape of fluctuations in atrophy and muscle wasting. Methods: The subjects of this study included 25 male Wistar rats (weight: 250± 30 g, age: 12 weeks) which were homogenized by weight and randomly divided into 5 groups (5 heads in each group) of healthy controls. Cancer control group, cancer group + quercetin supplement, cancer group + aerobic exercise, cancer group + quercetin supplement + aerobic exercise was evaluated. Measurements of IGF1 and myostatin in muscle tissue of rats were performed according to the standard and ELISA method. SPSS software was used for data analysis. Results: The results showed that 8 weeks of aerobic training in muscle tissue of mice with colon cancer had a significant effect on the mean values of myostatin (p = 0.005) and IGF1 (p = 0.019). 8 weeks of quercetin supplementation in muscle tissue of mice with colon cancer had a significant effect on mean myostatin and mean values IGF (P <0.05) in the control and experimental groups (8 weeks of quercetin supplementation) had no significant effect on mean myostatin and IGF1. (P>0/05) Conclusion: In general, the findings showed that aerobic exercise and quercetin supplementation improve IGF1 and reduce myostatin in muscle tissue of mice with colon cancer.
Exercise Physiology
Solmaz Babaei; Morteza Fattahpour Marani
Abstract
Aim: Myostatin and follistatin proteins are important proteins in the regulation of muscle tissue. Therefore, the aim of this study was to investigate the effect of 8 weeks of HIIT training on the serum levels of myostatin and follistatin in inactive young women.Method: The present study was conducted ...
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Aim: Myostatin and follistatin proteins are important proteins in the regulation of muscle tissue. Therefore, the aim of this study was to investigate the effect of 8 weeks of HIIT training on the serum levels of myostatin and follistatin in inactive young women.Method: The present study was conducted in a semi-experimental manner with two experimental and control groups on 30 inactive young women in the age range of 30-35 years. The experimental group performed HIIT exercises for 8 weeks, and three sessions per week for 60 minutes with an intensity of 65-75% of the maximum heart rate, and during this period, the control group had no physical activity. Blood samples were taken after 48 hours before and after exercise intervention in order to measure myostatin and follistatin variables. Data were analyzed using covariance test.Result: The results of this research showed that the serum level of myostatin decreased significantly in the experimental group compared to the control group after 8 weeks of HIIT exercises (P<0.001), while the serum level of follistatin increased significantly in the experimental group compared to the control group in the post-test. You have shown (P<0.001).Conclusion: HIIT exercises can decrease the expression of myostatin and increase the expression of follistatin in human samples and can lead to muscle hypertrophy and can be used as an exercise intervention in the rehabilitation program of inactive women. be placed.Keywords: HIIT; Myostatin, follistatin, young women
Exercise Physiology
Roghayeh Pouzesh Jadidi; Fatemeh Baradari; Jabraeel pouzesh jadidi; Amir Dadashzadeh
Abstract
Aim: The aim of this study was to determine the Effects of aerobic training and High Fat Diet on the Gene Expression of Bax and Bcl-2 in the myocardium of adolescent male rats. Methods: forty young male rats (30 days old) randomized in normal diet control (NDC), normal diet training (NDT), high fat diet ...
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Aim: The aim of this study was to determine the Effects of aerobic training and High Fat Diet on the Gene Expression of Bax and Bcl-2 in the myocardium of adolescent male rats. Methods: forty young male rats (30 days old) randomized in normal diet control (NDC), normal diet training (NDT), high fat diet control (HFDC) and high fat diet training (HFDT) groups. HFD rats followed high fat regimen (5.817 kcal/g) for 30 days and the normal fat diet (3.801 kcal/g) was continued following to the 60th day of birth. Aerobic training was conducted for four weeks included on three training sessions from the 70th to 98th days of life. Results: Our findings showed that in HFD groups the expression of Bax protein (from the apoptotic susceptible protein family) was increased and exercise was quite effective in preventing this increase. Instead, the high-fat diet caused a (but brief and insignificant) decrease in the expression of the BCL2 protein (from the family of anti-apoptotic proteins), although the effect of exercise and high-fat diet was not significant. Also, High fat diet increased the ratio of Bax protein expression to BCL2 protein expression (as an index of overall outcome reflecting , while training was well able to prevent this increase. Conclusion: Overall, based on the results of this study, we conclude that consumption of high fat diet may also induce cardiac apoptosis even in adolescence and in addition to good physical activity in neutralizing these adverse effects of high fat diet is helpful.
Exercise Physiology
Fazel Bazyar halimehjani; Ramin Shabani; َAlireza Elmiyeh
Abstract
Introduction: Alzheimer's is a destructive brain disease that causes progressive cognitive disorders for which there is no cure. The aim of the present study was to investigate the effect of aerobic exercise along with the consumption of saffron extract on spatial memory and the amount of tau protein ...
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Introduction: Alzheimer's is a destructive brain disease that causes progressive cognitive disorders for which there is no cure. The aim of the present study was to investigate the effect of aerobic exercise along with the consumption of saffron extract on spatial memory and the amount of tau protein accumulation in the hippocampal tissue of Alzheimer's induced male rats.Method: In this experimental study, 32 adult male rats were randomly divided into 4 Alzheimer's groups including control, aerobic exercise, aerobic exercise, extract and extract. Aerobic exercises including 3 training sessions per week were performed for 8 weeks. Y maze test was used to check spatial memory and ELISA method was used to measure tau protein. One-way analysis of variance was used to analyze the data.Findings: The results showed that after 8 weeks of aerobic training with saffron supplement, there was a significant increase in spatial memory performance in the intervention groups compared to the control group (P < 0.5). Also, regarding the amount of tau protein accumulation in the aerobic exercise group, aerobic exercise and extract showed a significant decrease compared to the control group (P < 0.5).Conclusion: It seems that aerobic exercise and consumption of saffron extract improves spatial memory performance and reduces the accumulation of tau protein in the hippocampal tissue of Alzheimer's male rats.
Exercise Physiology
Moinreh Kocheki; mohsen avandi; Abdosaleh Zar; Hamid Reza Sadeghipour
Abstract
Aim: Obesity is one of the most serious health problems associated with inflammation. Physical activity is one of the many factors that affect obesity and inflammation. The aim of the present study was to evaluate the effect of six weeks of resistance training and high intensity functional training cross-fit ...
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Aim: Obesity is one of the most serious health problems associated with inflammation. Physical activity is one of the many factors that affect obesity and inflammation. The aim of the present study was to evaluate the effect of six weeks of resistance training and high intensity functional training cross-fit on serum vaspin levels in obese women. Methods: The research method was quasi-experimental with pre-test-post-test design. Thirty six obese women of Semnan (age: 32.66 ± 3.91, weight: 86.97± 9.08 and BMI> 30) were selected as available and divided into three groups of high intensity functional resistance training (HIIF), Circular resistance training and control group (n = 12). The total training period consisted of 6 weeks and 3 sessions per week and each session was about 60 minutes. Serum levels of vaspin were avaluated befor and after the last training session. Results: Serum vaspin levels did not change significantly in the circular resistance training group (P=0.876) and Crossfit training group (P=0.837). But the body mass index was significantly decreased in the circular resistance training group (P=0.001) and the Crossfit training group (P=0.006). Conclusions: Circuit resistance training and Crossfit reduce the body mass of obese women, but they do not have a significant effect on the serum level of vaspin. It is suggested to use circular resistance exercises and HIFT with a longer duration for a better effect.
Exercise Physiology
Zahra Soltani; Homa Sheikhani Shahin
Abstract
Aim: Dietary supplementation with inorganic nitrate (NO3‒) may enhance exercise performance by improving skeletal muscle contractility and metabolism. CrossFit also, is recognized as a new method improves exercise performance but the interaction effects of nitrate supplements and CrossFitt on exercise ...
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Aim: Dietary supplementation with inorganic nitrate (NO3‒) may enhance exercise performance by improving skeletal muscle contractility and metabolism. CrossFit also, is recognized as a new method improves exercise performance but the interaction effects of nitrate supplements and CrossFitt on exercise performance are not well known. The present study was done to examine the interaction effects CrossFit training and beetroot juice on exercise performances in middle age inactive men.Methods: In this quasi study, twenty inactive men (aged 21-30 years old), were randomly divided into beetroot juice + CrossFitt group (n = 10) or placebo + CrossFitt group (n = 10). All participants were performed CrossFit training 3 days a week for 8 weeks. At the end week of the intervention, supplement group received 140 mL beetroot juice containing about 800 mg of NO3‒ per day. Exercise performances were evaluated before and after the intervention.Results: The results demonstrated that sprint, anaerobic power and vertical jump test were improved in the both groups (P<0.05), however no significant differences were observed between two groups. Peak aerobic power was increased in the both groups (P<0.05), while the increase of peak aerobic power was higher in the supplement group compare to the placebo group (P<0.05). Conclusion: Generally, we can conclude that CrossFit training caused improves exercise performance but the interaction of beetroot juice and CrossFit cannot enhance these performances.
Exercise Physiology
Maryam Belbasi; Asieh Abbassi Daloii; Ahmad Abdi
Abstract
Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) ...
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Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) and Adipocyte fatty acid-binding protein (A-FABP) levels of adipose tissue in type 2 diabetic obese rats. Method: To implementation of this experimental research, 32 obese male wistar rats (weight 320±20 gr) randomly were divided into 4 groups including obese control, shem (obese), obese diabetic, obese diabetic - high-intensity interval training. Intraperitoneal injection of nicotinamide amide-streptozotocin was used to induction type 2 diabetes. high-intensity interval training program was performed 4 days a week for six weeks. VEGF-A and A-FABP levels in rat adipose tissue were measured using by ELISA kit. Results: the VEGF-A level in adipose tissue in the obese diabetic group was significantly lower than the obese control group (P=0.001). Also, A-FABP (P=0.001) and insulin resistance (P=0.004) was significantly higher in the obese diabetic group than the obese control groups. High-intensity interval training was associated with significant increase of VEGF-A and decrease A-FABP levels in adipose tissue and insulin resistance in obese diabetic rats (P=0.001). Conclusion: It seems that high-intensity interval training can help improve adipose tissue metabolic parameters and insulin resistance in obese diabetic rats.
Exercise Physiology
mehrzad moghadasi; Nasrin Mortazavi Imami
Abstract
Aim: Exercise is recommended for the management of type 2 diabetes, but its effects on renal function in patients with type 2 diabetes are not well known. The aim of present study was to examine the effect of 8 weeks resistance training on glomerular filtration rate (eGFR) and CD5 antigen-like (CD5L) ...
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Aim: Exercise is recommended for the management of type 2 diabetes, but its effects on renal function in patients with type 2 diabetes are not well known. The aim of present study was to examine the effect of 8 weeks resistance training on glomerular filtration rate (eGFR) and CD5 antigen-like (CD5L) of male patients with type 2 diabetes.Methods: Twenty-two men (age: 51.5 ± 3.3 years and body mass index: 27.1 ± 3.2 kg/m2 mean ± SD) with type 2 diabetes participated as the subject. The subjects were randomly assigned to control or training group based on their eGFR. The subjects in the training group performed 3 sets with 8 to 15 repetitions of resistance training with 50-80% 1RM, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Fasting blood sugar, fasting insulin, insulin resistance, eGFR and CD5L were measured at baseline and 48h after the intervention.Results: The results indicated that fasting blood sugar, insulin resistance index and CD5L decrease in the training group compare to the control group (P<0.05); however, fasting insulin has no significant change after the intervention. Although eGFR has no significant change in the training group; but it was decreased significantly in the control group (P<0.05).Conclusion: In summary, it seems that resistance training utilized in this study improves blood glycemic and renal function in patients with type 2 diabetes.
Exercise Physiology
Mitra Khademosharie; Azam Mollanovruzi
Abstract
Background and Objective: Interleukin-6 is the major cytokine involved in initiating the acute phase response, which triggers the synthesis of certain proteins in the liver, such as C-reactive protein. The aim of this study was to investigate the effect of different periods of active recovery on ...
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Background and Objective: Interleukin-6 is the major cytokine involved in initiating the acute phase response, which triggers the synthesis of certain proteins in the liver, such as C-reactive protein. The aim of this study was to investigate the effect of different periods of active recovery on serum IL-6 and hs-CRP response after one session of intense intermittent activity in female swimmers.Methods: In this quasi-experimental study, 10 female swimmers ranging in age from 20 to 26 years were divided into two experimental groups: group 1 (n = 10) and group 2 (n = 10). The subjects swam the distances of 25 meters with maximum speed, the active recovery time in experimental group 1 was three times the duration of swimming and in experimental group 2 was four times the duration of swimming. The intensity of activity during active recovery was considered to be 50 to 60% of the maximum heart rate of the subjects, the subjects swam distances of 25 meters until exhaustion. Blood samples were collected before the start of the training session and after the recovery phase. ANOVA with repeated measures was used to analyze the data. All statistical operations were performed using SPSS software version 16 and the significance level was considered P <0.05.Result: The results of this study showed that there was no significant difference between female swimmers in the effect of two periods of active recovery 1: 3 and 1: 4 on serum hs-CRP (P=0.17) and IL-6 (P=0.24) response after one session of intense interval swimming to exhaustion.Conclusion: Swimmers can use both 3-fold recovery times and 4-fold recovery times, and these two types of recovery was not significantly different in terms of affecting IL-6 and hs-CRP response.
Exercise Physiology
Masoud Asgharpour-arshad; HASSAN POURRAZI; Rasoul Bakhshi
Abstract
Aim: The aim of this study was to determine the effect of 12-week high-intensity interval training on heart mass and expression of beta-catenin and glycogen synthase kinase-3-beta genes in myocardial tissue of male rats.Method: Thirty male Wistar rats were randomized into three groups, including sham ...
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Aim: The aim of this study was to determine the effect of 12-week high-intensity interval training on heart mass and expression of beta-catenin and glycogen synthase kinase-3-beta genes in myocardial tissue of male rats.Method: Thirty male Wistar rats were randomized into three groups, including sham (n = 10), control (n = 10), and HIIT (n = 10). The experimental group underwent HIIT consisting of 2 - 8 repetitions of 4-min high-intensity intervals (85% - 90% peak speed) interspersed with low-intensity intervals (45% - 50% peak speed), performed five times/week over 12 weeks. Forty-eight hours after the last training session, animals’ hearts were removed. The gene expressions of beta-catenin and glycogen synthase kinase-3-beta were analyzed by the RT-PCR method. The independent t-test was used for statistical analysis (P < 0.05).Results: The results showed that the body weight was significantly lower in HIIT group (P = 0.029) and heart/body weight ratio were significantly higher in the intervention group than in the control group (P = 0.001). Also, beta-catenin gene expression were significantly higher in trained rats than the control group (P = 0.002). Regarding GSK3-β genes expression, although mean levels were lower in the trained group than the control, the differences were statistically insignificant (P = 0.71).Conclusions: HIIT training, along with considerable reduction of body weight, increase the ratio of heart to body weight and cardiac hypertrophy. Also, these exercise training trigger cardiac hypertrophic signals by stimulating the Wnt signaling pathway and significantly increasing beta-catenin gene expression.
Exercise Physiology
Omid Reza Salehi; Dariush Sheikholeslami-Vatani; Sayed Ali Hosseini
Abstract
Introduction: Aging is associated with neurodegenerative and psychological disorders. Considering the ambiguity in the interactive effect of exercise and antioxidants, the aim of this study was to investigate the psycho-physiological effects of high intensity interval training (HIIT) and vitamin E (VE) ...
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Introduction: Aging is associated with neurodegenerative and psychological disorders. Considering the ambiguity in the interactive effect of exercise and antioxidants, the aim of this study was to investigate the psycho-physiological effects of high intensity interval training (HIIT) and vitamin E (VE) in elderly trimethyltin (TMT)-treated Alzheimer's rats.Methods: In this experimental study, 50 Alzheimer's rats (age 18-22 months; weight 280-320 grams) induced by 10 mg/kg TMT were divided into five groups, including: (1) TMT, (2) sham/ vitamin E solvent, (3) VE, (4) HIIT (90-95% of the maximum speed) and (5) HIIT+VE. Ten healthy rats were included in the healthy control (HC) group to investigate the effect of TMT on research variables. HIIT was performed for eight weeks, three sessions per week, and VE was given orally to the rats at a dose of 30 mg/kg. Results: In the HIIT and HIIT+VE groups, anthropometric indicators, food intake, anxiety and depression were significantly lower, and aerobic capacity, movement balance, and pain tolerance threshold were higher than the TMT group (P≥0.05). In the VE group, visceral fat weight, food intake, anxiety and depression were significantly lower than the TMT group (P≥0.05). Aerobic capacity was significantly higher in HIIT and HIIT+VE groups, and anxiety and depression were significantly lower than in the VE group (P≥0.05).Conclusion: It seems that HIIT, VE and HIIT + VE improve the weight, BMI and FW and physical and psychological performance, but the effects of HIIT on physical and psychological performance are much stronger than the effect of VE.
Exercise Physiology
Morteza Fattahpour Marani; Solmaz Babaei
Abstract
Aim: physical activity can play a supportive role in breast cancer improvement by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory cytokine that plays an important role in preventing the growth and metastasis of breast cancer, and interleukin 4 is an inflammatory cytokine that ...
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Aim: physical activity can play a supportive role in breast cancer improvement by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory cytokine that plays an important role in preventing the growth and metastasis of breast cancer, and interleukin 4 is an inflammatory cytokine that causes the growth and development of cancer cells. The present study was conducted with the aim of investigating the effect of 12 weeks of Pilates exercises on the serum levels of interleukin 4 and interleukin 10 in women with breast cancer. Method: The present study was conducted in a semi-experimental manner with two experimental and control groups on 30 women with breast cancer. The experimental group was given Pilates exercises for 12 weeks and 3 sessions each week for 60 minutes, while the control group did not participate in any physical activity. Blood samples were taken 48 hours before and after exercise intervention to measure interleukin 4 and 10 variables. Results: Based on the results of the correlated t test, the serum level of interleukin 10 in the experimental group increased significantly compared to the control group (P=0.001), and the amount of interleukin 4 in the experimental group showed a significant decrease compared to the control group(P=0.001).Conclusion: Performing Pilates exercises with the benefit of anti-inflammatory cytokines and reducing inflammatory cytokines improves the health status of women with breast cancer. Therefore, doing exercises can help patients as a therapeutic factor. Keywords: interleukin 10, interleukin 4, Pilates exercises, breast cancer
Exercise Physiology
Mohammad Rahman Rahimi; Hassan Faraji; sahar shamlooee
Abstract
Introduction: The aim of the present study was to investigate the effect of MCT1 A1470T polymorphism (rs 1049434) on one repetition maximum muscle strength in young athletes of the speed and endurance strength group in the chest press and squat-smith tests.Methodology: 49 young trained male athletes ...
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Introduction: The aim of the present study was to investigate the effect of MCT1 A1470T polymorphism (rs 1049434) on one repetition maximum muscle strength in young athletes of the speed and endurance strength group in the chest press and squat-smith tests.Methodology: 49 young trained male athletes with average age (24.22±5.54 years), height (178.57±8.91 cm), and weight (75.32±13.31 kg) were included in this research with the entry criteria. Muscle strength was calculated during one session using a maximum repetition test in two parts of the upper body (chest press test) and lower body (squats) for each subject. ARMS-PCR method was used to determine the genotype of the samples.Results: The results showed that there is a significant difference between the genotypes of the MCT1 polymorphism in one repetition of the maximum muscle strength of the Scott-Smith test in athletes (F=51.3, p=0.038) that the TT genotype with the highest strength in the test Scott Smith was with him. LSD post hoc test showed that subjects with genotype (TT+AT) have more strength compared to subjects with genotype (AA+AT). In the strength group between genotypes (AA and TT) in one repetition of maximum Scott-Smith muscle strength, the difference It was significant (p=0.047, F=3.54) and people with TT genotype had the highest strength in the Scott-Smith test.Conclusion: The TT genotype of the MCT1 polymorphism has been associated with the lower body muscle strength of athletes and the effect of this genotype was evident in the athletes of the strength group.
Exercise Physiology
Aylar Fathi; simin namvar
Abstract
Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. ...
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Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. The aim of the current research was to study the effect of six weeks of continuous aerobic training on the neuronal density of the hippocampus CA1 region and memory performance.The current research was carried out experimentally. The statistical population was male Wistar rats with a weight range of 300 to 350 grams. For this purpose, 40 11-month-old male rats were prepared and randomly divided into four groups of 10 including the training patient group, control patient group, healthy training group and healthy control group. The rats performed the relevant exercises for six weeks by repeating five sessions per week. 48 hours after the last session, brain tissue was removed and data were collected. Neuronal density was measured by histological method and memory performance by novel object recognition test. The results were extracted using two-way variance analysis at a significance level of p≥0.05.Neuron density in the hippocampus in the training patient group increased significantly compared to the control patient group. Also, improvement of memory performance was observed in the training patient group compared to the control patient group (p=0.004). Performing continuous aerobic exercises for six weeks increases the neuronal density in the hippocampus and improves memory function in Alzheimer's disease.
Exercise Physiology
maryam Molaei Jeghanab; mandana gholami; Abdolali Banaeifar; Farshad Ghazalian
Abstract
Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating ...
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Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating with pathologic effects of type 2 diabetes. The aim of present study is to determine the effect of eight weeks resistance training along withvitaminD consumption on levels of chemerin and omentin-1 in type 2 diabetic patientsMethod: 40 diabetics men with average age of 47.19±3.83 years old and body fat percentage 30.96±2.49 assigned in four groups including the placebo, vitaminD, training and training+ vitaminD groups. The resistance training program conducted for eight weeks and three session per week with 60 to 70 percent of 1RM intensity. VitaminD consumption considered daily 2000 iu and placebo (oral paraffin) ingestion considered in the same amount. At the baseline and ending intervention, blood samples collected and the levels of chemerin and omentin-1 were measured and insulin resistance calculated. Data were analyzed by analysis of covariance test and Bonferroni post-hoc test.Results: The present study findings indicated that in training and training+vitaminD groups the chemerin levels significantly decreased and omentin-1 significantly increased (p<0.05). Moreover, significant decrease of insulin resistance was observed in training and training+vitaminD groups (p<0.05).Conclusion: VitaminD ingestion can increase the hypoglycemic effects of resistance training partly, which these positive effects of resistance training and vitaminD consumption exerted by increase in omentin1 levels and decrease of chemerin levels.
Exercise Physiology
Mehdi Pahlevani; Jabbar Bashiri; Roghayeh Pouzesh Jadidi; Rasoul Hashem Kandi Asadi; Masoomeh Dadkhah
Abstract
Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental ...
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Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.
Exercise Physiology
ADEL DONYAEI; Abolfazl Khosravi; Masoud Ardeshiri; farhad gholami
Abstract
Objectives: exercise training has a remarkable metabolic and appetite-regulating effects. Appetite-regulating effects of exercise training may be altered by fasted and fed status. Methodology: in a randomized trial, 54 obese men with BMI > 30 kg/m2 were randomly divided into groups including 2 experimental ...
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Objectives: exercise training has a remarkable metabolic and appetite-regulating effects. Appetite-regulating effects of exercise training may be altered by fasted and fed status. Methodology: in a randomized trial, 54 obese men with BMI > 30 kg/m2 were randomly divided into groups including 2 experimental groups of training (fasted and fed) and control. The experimental groups performed a concurrent exercise program including aerobic training (walking/ running at 60-70% of heart rate reserve lasting 30 minutes) followed by strength training (circuit training with 10 repetitions for each exercise in 3 rounds interspersed with 2-3 min rest) with a frequency of 3 d/w over 8 weeks. The fasted group performed exercise program following overnight fasting, and the fed group performed the exercise program following breakfast. At the beginning and 48 hours after the last training session measurements were performed. Data were analyzed using one-way analysis of variance at a significance level of 0.05. Results: concurrent training resulted in a significant decrease in leptin (p=0.001) as well as the appetite (p=0.002) compared to the control group; yet, no significant difference was observed between the two experimental groups (P<0.05). Furthermore, ghrelin significantly decreased in the experimental groups compared to the control (p=0.001) and a significant difference between the two experimental groups was also observed (p=0.013). Conclusion: The findings of the present study indicates that appetite and leptin are remarkably affect by concurrent training but not by pre-exercise feeding status. However, ghrelin resting concentration is likely to be affect by pre-exercise feeding status (fasted vs fed).
Exercise Physiology
hamid malekshahiniya; Roohollah Mohammadi Mirzaei; Halimeh vahdatpoor; M Azarniveh
Abstract
Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide ...
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Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients.
Exercise Physiology
nooshin salehi aghdam; Roghayeh Pouzesh Jadidi; Karim Azali Alamdari; jabbar bashiri; Mir Ali Reza Nourazar
Abstract
Aim: we investigated the effects of six weeks of HIIT and curcumin supplementation on hepatic cellular death and also GSH level in male rats exposed to drinking water arsenic.Methods: 48 rats were randomized in six groups including HIIT, curcumin, HIIT+curcumin, arsenic, ethanol control and normal control. ...
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Aim: we investigated the effects of six weeks of HIIT and curcumin supplementation on hepatic cellular death and also GSH level in male rats exposed to drinking water arsenic.Methods: 48 rats were randomized in six groups including HIIT, curcumin, HIIT+curcumin, arsenic, ethanol control and normal control. Arsenic 5 mg/bw.day and curcumin 15 mg/bw.day, were consumed orally for entire the study period. HIIT were conducted for six weeks (5 d/w, 60 min/session (with 4 min running at 85-90% of Vo2max and 2 min recovery at 50-60% of Vo2max intervals). Results: Arsenic exposure down regulated hepatic CK18 M65 level and also in a lesser extent; the cellular GSH content. Curcumin supplementation either alone or concomitantly with HIIT, could reverse the changes in hepatic CK18 M65 level. However; only in the HIIT+curcumin group, a remarkable elevation of hepatic GSH level was observed. Conclusion: Arsenic exposure renders liver to an increased oxidative stress and apoptosis level and the both HIIT and curcumin supplementation have appreciable effects to neutralize these hazardous effects. Moreover, only the synergistic effect of HIIT and curcumin supplementation could attenuate the liver antioxidants following arsenic exposure. However, more investigations remains to be done because of the study limitations and lack of similar evidence in this area.
Exercise Physiology
Navid Nateghi; Arsalan Damirchi; Javad Mehrabani; Razhan Piran
Abstract
Hypertension similar to dyslipidemia is most important cardiovascular diseases that exercise training can have a preventive and therapeutic effect on them. The effect of combined exercise training as an effective method is one of the new ways to combat hypertension and cardiovascular health. The purpose ...
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Hypertension similar to dyslipidemia is most important cardiovascular diseases that exercise training can have a preventive and therapeutic effect on them. The effect of combined exercise training as an effective method is one of the new ways to combat hypertension and cardiovascular health. The purpose of this study was to investigate the effect of combined exercises training on cardiovascular inflammatory markers and blood pressure in hypertensive men.In this study that designed with pre-post tests with control group, 9 men (47.33±4.5 years; body mass index 33.18±5.27 kg/m2) as combined training group [COT] and 9 as control group [CON] (48.44±3.20 years; body mass index 30.51±5.35 kg/m2) were randomly selected from volunteers. Combined training (aerobic and resistance) that performed in 16 weeks consisted of 4 sessions per week (2 sessions of aerobic and dynamic resistance training, respectively). Aerobic training with 40-65% maximal oxygen uptake (70-80 minutes) and dynamic resistance training with 55% maximum repetition (70-80 minutes) were performed. Results of ANCOVA test showed that systolic and diastolic blood pressure, galactin-3 and endothelin-1 plasma levels were significantly decreased in the post exercise training group as well as in the control group (p<0.05). In lipid profile, we observed significant decrease in total cholesterol (TChol) in combined exercise training group (p<0.05). It can be concluded that, the results showed that the combination of aerobic and resistance training, in addition to lowering blood pressure and improvement of dyslipidemia in men with hypertension, led to a decrease in biomarkers affecting vascular inflammation and heart failure.
Exercise Physiology
Fateme Mokhtari; Elahe Talebi Garakani; Khadije Nasiri; Abolfazl Akbari
Abstract
Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into ...
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Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into 2 groups: normal and exposed to dexamethasone. Dexamethasone group were randomly divided into 6 groups. control (C), Silymarin (S), continues training (CT), and continues training+silymarin (CTS), high intensity interval training (HIT), high intensity interval training+Silymarin (HITS). Silymarin groups, received 300 mg. kg-1.d-1 of silymarin solution through gavage. Animals in HIT groups performed 3-min bouts at 40 m/min, interspersed by 3-min active recovery at a running velocity of 20 m/min on a motorized treadmill with 15% incline, repeated six times per session. Continues training groups performed steady state running at the same speed as the active recovery's speed in the HIT group. Liver histological modifications and serum levels of alanine aminotransferase (ALT) and Aspartate transaminase (AST) were measured. Results: Silymarin consumption and aerobic training were able to improve histological changes compared with control group. Interactive effect of silymarin supplementation and training on AST and ALT levels was not significant. Silymarin reduced liver AST and ALT levels (p≤0.05). Also, AST levels were significantly higher in HIT group than in control group (p≤0.05). The amount of this enzyme in the HITS was significantly reduced compared to HIT group (p≤0.05). Conclusion: Silymarin supplementation and aerobic training separately and in combination may improve liver histological status of rats with dexamethasone-induced nonalcoholic fatty liver.
